Assessment of the antioxidant levels in sera of periodontitis patients with or without diabetes mellitus

Thomas, Biju; Varma, Sudhir; Prasad, Rajendra; Shayeb, Maher Al; Khair, Moutassem Billah; Elkaseh, Abed M. A; Elsubeihi, Emad S.; Shahwan, Moyad

doi:10.5958/0974-360x.2021.00183.9

Cited by 5 publications

(8 citation statements)

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“…As for GSH, we did not find significant differences in GSH values in patients with periodontitis with or without type 2 diabetes, contrary to the findings of Akazawa, 47 Guan et al, 48 and Thomas et al, 23 who reported significant higher or lower GSH values in DMCP as compared to controls and the explanation is site differences in the samples tested, with reduced and increased GSH detected in saliva and serum of DMCP patients, respectively.…”

Section: Discussioncontrasting

confidence: 99%

“…The meta-analysis of five 11,12,[21][22][23] studies with 444 subjects revealed no significant difference in the level of SOD between DMCP group than the CP group under a random-effects model (SMD = 0.79; 95% CI: −0.49, 2.01; Figure 3), with statistically significant heterogeneity (p = .2, I 2 = 96.8%; τ 2 = 1.466).…”

Section: Sodmentioning

confidence: 97%

“…Of all the original articles, seven studies 11,21,[23][24][25][26][27] involving 539 subjects reported TAOC values in DMCP and CP participants, and the final results of the meta-analysis showed that TAOC values in DMCP were not significantly different in systemically healthy CP patients (SMD = −0.52; 95% CI: −1.32, 0.28; Figure 3). There was statistically significant heterogeneity (p = .21, I 2 = 94.3%; τ 2 = 1.079).…”

Section: Taocmentioning

confidence: 99%

“…A total of four original studies, 11,22,23,28 involving 205 DMCP as well as 205 CP control participants, showed lower CAT levels in the DMCP group than in the CP control group. The same result was also seen in our meta-analysis (SMD = −0.37; 95% CI: −0.58, −0.16; Figure 3).…”

Section: Catmentioning

confidence: 99%

“…Three studies 23,24,28 provided data on GSH levels, and the results of the meta-analysis showed that GSH levels in the DMCP group were not significantly different from those in the CP control group (SMD = 0.06; 95% CI: −0.78, 0.90; Figure 3), with statistically significant heterogeneity (p = .88; I 2 = 91.6%; τ 2 = 0.498).…”

Section: Gshmentioning

confidence: 99%

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Oxidative stress‐related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta‐analysis

Chen

Gao

Song

2023

J of Periodontal Research

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Objective The purpose of this meta‐analysis was to look at the differences in oxidative stress (OS) biomarkers between type 2 diabetes mellitus with chronic periodontitis (DMCP) and chronic periodontitis (CP) patients. Background Oxidative stress has been shown to be a key pathogenic component in DMCP. However, it is unclear whether oxidative stress levels differ in periodontitis patients with or without diabetes. Method A systematic search was conducted on PubMed, Cochrane, and Embase databases. Studies of DMCP participants were used as the experimental group and CP participants were used as the control group. Results are expressed as mean effects. Results Of a total of 1989 articles, 19 met the inclusion criteria. We found the levels of catalase (CAT) levels were reduced in the DMCP group compared with the CP group. However, there was no significant difference in the levels of superoxide dismutase (SOD), total antioxidant capacity (TAOC) malondialdehyde (MDA), and glutathione (GSH) between the two groups. And high heterogeneity was observed in some of the studies evaluated. Conclusion Despite the limitations of this study, our results support the theory that there is an association between T2DM and the levels of OS‐related biomarkers, especially CAT, in CP subjects, suggesting that OS plays an important role in the pathogenesis and development of DMCP.

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Section: Discussioncontrasting

confidence: 99%

Section: Sodmentioning

confidence: 97%

Section: Taocmentioning

confidence: 99%

Section: Catmentioning

confidence: 99%

Section: Gshmentioning

confidence: 99%

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Oxidative stress‐related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta‐analysis

Chen

Gao

Song

2023

J of Periodontal Research

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The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis

Mohideen,

Krithika,

Jeyanthikumari

et al. 2024

Clinical & Exp Dental Res

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ObjectiveThe present systematic review explored the involvement of enzymatic and nonenzymatic antioxidants in periodontitis, drawing from established literature.Materials and MethodsThe research approach encompassed an extensive electronic search from 2000 to 2023 across databases such as PubMed, Science Direct, and Wiley Online Library and cross‐referencing using specific keywords.ResultsThe initial literature exploration generated a total of 766 articles. After thoroughly examining the abstracts, 693 articles were excluded from consideration due to duplication and lack of relevance to the central research inquiry. Following that, 73 articles were left for in‐depth evaluation. Following a qualitative assessment, 35 studies that satisfied the inclusion criteria were chosen, while 38 were removed for not meeting the necessary standards. Within this selection, a meta‐analysis was conducted on 11 articles that provided consistent data for quantitative synthesis. Specifically, the analysis of glutathione (GSH) levels in serum samples revealed a standardized mean difference (SMD) of −5.552 µg/mL (CI 95%: −9.078 to −2.026; P‐0.002). In contrast, the analysis of glutathione peroxidase (GPx) enzymes in gingival crevicular fluid (GCF) samples displayed an overall SMD of 2.918 ng/µL (CI 95%: 0.372–5.465; P‐0.025), while salivary samples exhibited an overall SMD value of 0.709 U/l (95% CI: −1.907–3.325; P‐0.596) which is of insignificant.ConclusionThe systematic review findings suggest a notable decrease in antioxidant enzymes across various systemic biological samples among patients with periodontitis, contrasting with the results from gingival tissue samples meta‐analysis of GPx enzyme.

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Redox biomarkers in saliva and nuclear abnormalities in jugal epithelial cells of individuals with type 2 diabetes mellitus and periodontitis

Lobão,

Zajdenverg,

Lopes

et al. 2024

Archives of Oral Biology

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Assessment of the antioxidant levels in sera of periodontitis patients with or without diabetes mellitus

Cited by 5 publications

References 0 publications

Oxidative stress‐related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta‐analysis

Oxidative stress‐related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta‐analysis

The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis

Redox biomarkers in saliva and nuclear abnormalities in jugal epithelial cells of individuals with type 2 diabetes mellitus and periodontitis

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