Assessment of the alcohol withdrawal syndrome—validity and reliability of the translated and modified Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA‐A)

Stuppaeck, C.; Barnas, C.; Falk, Markus; Guenther, V.; Hummer, Martina; Oberbauer, H.; Pycha, Roger; Whitworth, Alexandra B.; Fleischhacker, W. Wolfgang

doi:10.1111/j.1360-0443.1994.tb03307.x

Cited by 79 publications

(38 citation statements)

References 3 publications

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“…Alcohol withdrawal symptoms were assessed by two specialists in psychiatry using the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale [20] , 48 h after the last consumption of alcohol. The CIWA-Ar scale consists of ten items.…”

Section: Assessment Of Alcohol Withdrawal Symptomsmentioning

confidence: 99%

Clinical Manifestation of Alcohol Withdrawal Symptoms Related to Genetic Polymorphisms of Two Serotonin Receptors and Serotonin Transporter

Lee

Choi²,

Han³

et al. 2008

Eur Addict Res

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Aim: The purpose of this study was to investigate the role of serotonergic genes in the development of alcohol dependence. The manifestation of alcohol withdrawal symptoms related to serotonergic polymorphisms in alcoholics was also examined. Methods: The role of polymorphisms in the serotonin receptor 1A (5-HT1A), serotonin receptor 2A (5-HT2A), and the serotonin transporter gene (5-HTT) promotor region (5-HTTLPR) in the manifestation of individual alcohol withdrawal symptoms was investigated in 97 Korean male inpatients with alcohol dependence and 76 Korean healthy male subjects. The patient’s alcohol withdrawal symptoms were assessed with the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale. Results: In the 5-HT1A receptor, the frequency of G– genotype (CC) was significantly higher in patients with alcohol dependence than in normal controls (χ² = 5.03, p = 0.025). The CIWA-Ar subscale scores of nausea, anxiety, and headache, and total CIWA-Ar scale scores were significantly higher in G+ genotypes (CG+ GG) than in G– genotype (p = 0.005, p = 0.004, p = 0.008, and p = 0.008, respectively). Conclusion: The results suggest that the genetic polymorphism of the 5-HT1A receptor may play a role in alcohol dependence and polymorphisms of serotonergic genes may be important in withdrawal symptoms of patients with alcohol dependence.

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Section: Assessment Of Alcohol Withdrawal Symptomsmentioning

confidence: 99%

Clinical Manifestation of Alcohol Withdrawal Symptoms Related to Genetic Polymorphisms of Two Serotonin Receptors and Serotonin Transporter

Lee

Choi²,

Han³

et al. 2008

Eur Addict Res

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“…The validated German version of the CIWA-A scale by Stuppaeck et al [35] is a 12-item scale which comprises the following items: blood pressure, pulse rate, respiratory rate, body temperature, seizures, nausea/vomiting, tremor, hyperhidrosis, tactile/auditory/visual disturbances, orientation, concentration, nervousness/anxiety and headache. In contrast to the original scale by Sullivan et al [36] with grades from 0-7, the German CIWA-A scale uses grades from 1 (not existent) to 6 (maximum), except for seizures.…”

Section: S Inclusion Criteriamentioning

confidence: 99%

A combination of carbamazepine/tiapride in outpatient alcohol detoxification

Soyka

Morhart-Klute

Horak

2002

European Archives of Psychiatry and Clinical Neuroscience

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This was an open, prospective study to examine the efficacy, practicability and medical safety of a combination of carbamazepine and tiapride in outpatient detoxification of alcohol-dependent patients. Patients were carefully screened for relevant neuropsychiatric disorders and then seen on a daily outpatient basis. Patients received medication if the initial CIWA-A score exceeded 16 points. Fifty consecutively admitted patients entered the program; 49 (98 %) successfully ended treatment. The mean initial dose for carbamazepine was 628 mg or 332 mg for tiapride. No serious medical complications or adverse events were observed. In general, medication was well tolerated. Withdrawal symptomatology as indicated by CIWA-A scores clearly decreased over time. Most frequently named side effects were sedation (63 %), hyperhidrosis (49 %), lack of drive (38 %), dry mouth (31 %) and orthostatic dysregulation or vertigo (22 %). Results from this study suggest that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for outpatient alcohol detoxification in patients with moderate severity of withdrawal syndrome.

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“…Possible withdrawal symptoms were evaluated by the Clinical Institute Withdrawal Assessment for Alcohol [22]. The Alcohol Abstinence Self-Efficacy Scale with subscales concerning confidence and temptation of drinking alcohol was used to rate the individual ability to abstain from alcohol (Alcohol Abstinence Self-Efficacy Scale) [23].…”

Section: Methodsmentioning

confidence: 99%

Impact of Alcohol-Related Video Sequences on Functional MRI in Abstinent Alcoholics

Krienke

Nikesch²,

Spiegelhalder³

et al. 2013

Eur Addict Res

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The object of this study was the identification of brain areas that were significantly more connected than other regions with a previously identified reference region, the posterior cingulate cortex, during the presentation of visual cues in alcoholics. Alcohol-related and neutral video sequences were presented to 30 alcoholics who had been abstinent for at least 4 days. Participants underwent a psychometric assessment before and after the presentation of the video sequences. Functional MRI data were acquired. Psychophysiological interaction analyses were carried out. Participants reported a significant increase in craving and arousal after the presentation of alcohol-related video sequences. The simple contrast alcohol versus neutral was found not to be significantly different in the present study. The brain regions that were found to correlate significantly more with the posterior cingulate cortex under the alcohol-related condition were the inferior parietal lobe, the medial temporal lobe, the inferior frontal gyrus, the postcentral gyrus, and the precuneus. The involvement of these regions in processes of memory, self-control, and self-reflection with a particular focus on alcohol dependence and craving will be discussed.

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Assessment of the alcohol withdrawal syndrome—validity and reliability of the translated and modified Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA‐A)

Cited by 79 publications

References 3 publications

Clinical Manifestation of Alcohol Withdrawal Symptoms Related to Genetic Polymorphisms of Two Serotonin Receptors and Serotonin Transporter

Clinical Manifestation of Alcohol Withdrawal Symptoms Related to Genetic Polymorphisms of Two Serotonin Receptors and Serotonin Transporter

A combination of carbamazepine/tiapride in outpatient alcohol detoxification

Impact of Alcohol-Related Video Sequences on Functional MRI in Abstinent Alcoholics

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