Assessment of the accuracy of preoperative imaging methods in the diagnosis of hepatic single-chamber echinococcosis

Hołody-Zaręba, Joanna; Zaręba, Konrad; Kędra, Bogusław

doi:10.2478/pjs-2013-0106

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Ultrasonography is the most sensitive diagnostic tools and also used to classify the hydatid cyst with specificity and sensitivity up to 98% respectively (Hołody-Zaręba et al, 2013). In the present study, the accuracy of diagnosis depends on ultrasonography examinations, confirmed at surgery, with specific indications for CAT scan as anatomical cystic details, relation to other important structures, obstructive jaundice and solid component.…”

Section: Discussionmentioning

confidence: 63%

Comparison Between Omentoplasty and Partial Cystectomy and Drainage (Pcd) Techenques in Surgical Management of Hydatid Cysts Liver in Endemic Area (Yemen)

Borham

2014

Journal of the Egyptian Society of Parasitology

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Section: Discussionmentioning

confidence: 63%

Comparison Between Omentoplasty and Partial Cystectomy and Drainage (Pcd) Techenques in Surgical Management of Hydatid Cysts Liver in Endemic Area (Yemen)

Borham

2014

Journal of the Egyptian Society of Parasitology

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“…The sensitivity and specificity of serologic tests (indirect hemagglutination test and enzyme-linked immunoassay) for detecting hepatic echinococcosis infection have been reported in the literature to be 90–100% [ 29 ]. However, the sensitivity of serologic tests in cases of cerebral echinococcosis is uncertain when compared to hepatic echinococcosis [ 30 , 31 ]. In this study, some of the patients underwent echinococcus antibody testing using the ELISA method: one patient with CCE underwent antibody testing, and the result was negative, while seven patients with CAE also underwent antibody testing, of which five patients showed strong positive results, and two patients had suspicious positive results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinicopathological features between cerebral cystic and alveolar echinococcosis: analysis of 27 cerebral echinococcosis cases in Xinjiang, China

Ma,

Shi

et al. 2024

Diagn Pathol

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Background Cerebral echinococcosis is relatively rare, and it is important to distinguish cerebral cystic echinococcosis (CCE) from cerebral alveolar echinococcosis (CAE) in terms of pathological diagnosis. We aim to describe the different clinicopathological features among patients with CCE and CAE. Methods We collected 27 cases of cerebral echinococcosis which were diagnosed in the Department of Pathology of the First Affiliated Hospital of Xinjiang Medical University from January 1, 2012, to June 30, 2023. We compared the patients’ clinical characteristics, MRI features, and pathologic manifestations of CCE and CAE. Results Among 27 cases of cerebral echinococcosis, 23 cases were CAE and 4 cases were CCE. The clinical manifestations of both CCE and CAE patients mainly included headache (21 patients, 77.78%), limb movement disorders (6 patients, 22.22%), epileptic seizures (4 patients, 14.81%) and visual disturbances (2 patients, 7.41%). The average onset age of CAE cases was 34.96 ± 11.11 years, which was 9.00 ± 7.26 years in CCE cases. All CAE patients presented with multiple involvements in the brain and extracranial organs while all CCE patients observed a solitary lesion in the brain and 3 CCE cases had no extracranial involvement. Lesions of CCE in MRI showed a single isolated circular, which was well demarcated from the surrounding tissues and with no obvious edema around the lesions, whereas CAE lesions presented as multiple intracranial lesions, with blurred edges and edema around the lesions, and multiple small vesicles could be observed in the lesions. The edge of CAE lesions could be enhanced, while CCE lesions have no obvious enhancement. CCE foci were clear cysts with a wall of about 0.1 cm. Microscopically, the walls of the cysts were characterized by an eosinophilic keratin layer, which was flanked on one side by basophilic germinal lamina cells, which were sometimes visible as protocephalic nodes. While the CAE lesion was a nodular structure with a rough and uneven nodule surface, and the cut section was cystic and solid; microscopically, the CAE lesion had areas of coagulative necrosis, and the proto-cephalic nodes were barely visible. Inflammatory cell areas consisting of macrophages, lymphocytes, epithelioid cells, plasma cells, eosinophils, and fibroblasts can be seen around the lesion. Brain tissues in the vicinity of the inflammatory cell areas may show apoptosis, degeneration, necrosis, and cellular edema, while brain tissues a little farther away from the lesion show a normal morphology. Conclusions With the low incidence of brain echinococcosis, the diagnosis of echinococcosis and the differential diagnosis of CAE and CCE are challenging for pathologists. Grasping the different clinical pathology characteristics of CAE and CCE is helpful for pathologists to make accurate diagnoses.

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“…Imaging diagnosis can distinguish the two medically important CE and AE lesions (Brunetti et al ., 2010), but it fails to discriminate the CE lesions caused by E. granulosus s.s. and E. canadensis , respectively. In addition, misdiagnosis or uncertain cases can easily occur in imaging examination when encountering atypical pathological features, early stage or similar lesions, or inexperienced inspectors (Zhang and McManus, 2006; HołodyZaręba et al ., 2013; Mesut et al ., 2016). Although serology is a helpful tool for early diagnosis of echinococcosis, questions remain with regards to its specificity and effectiveness for clinical detection.…”

Section: Discussionmentioning

confidence: 99%

A multiplex PCR for the identification of Echinococcus multilocularis, E. granulosus sensu stricto and E. canadensis that infect human

Chen

Liu

et al. 2019

Parasitology

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Echinococcus granulosus sensu stricto (s.s.), Echinococcus multilocularis and Echinococcus canadensis are the common causes of human echinococcosis in China. An accurate species identification tool for human echinococcosis is needed as the treatments and prognosis are different among species. The present work demonstrates a method for the simultaneous detection of these three Echinococcus species based on multiplex polymerase chain reaction (mPCR). Specific primers of this mPCR were designed based on the mitochondrial genes and determined by extensive tests. The method can successfully detect either separated or mixed target species, and generate expected amplicons of distinct size for each species. Sensitivity of the method was tested by serially diluted DNA, showing a detection threshold as less as 0.32 pg for both E. granulosus s.s. and E. canadensis, and 1.6 pg for E. multilocularis. Specificity assessed against 18 other parasites was found to be 100% except weakly cross-react with E. shiquicus. The assay was additionally applied to 69 echinococcosis patients and 38 healthy persons, confirming the high reliability of the method. Thus, the mPCR described here has high application potential for clinical identification purposes, and can further provide a useful tool for evaluation of serology and imaging method.

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Assessment of the accuracy of preoperative imaging methods in the diagnosis of hepatic single-chamber echinococcosis

Cited by 8 publications

References 8 publications

Comparison Between Omentoplasty and Partial Cystectomy and Drainage (Pcd) Techenques in Surgical Management of Hydatid Cysts Liver in Endemic Area (Yemen)

Comparison Between Omentoplasty and Partial Cystectomy and Drainage (Pcd) Techenques in Surgical Management of Hydatid Cysts Liver in Endemic Area (Yemen)

Comparison of clinicopathological features between cerebral cystic and alveolar echinococcosis: analysis of 27 cerebral echinococcosis cases in Xinjiang, China

A multiplex PCR for the identification of Echinococcus multilocularis, E. granulosus sensu stricto and E. canadensis that infect human

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