Assessment of T1, T1ρ, and T2 values of the ulnocarpal disc in healthy subjects at 3 tesla

Rauscher, Isabel; Bender, Benjamín; Grözinger, Gerd; Luz, Oliver; Pohmann, R; Erb, Michael; Schick, Fritz; Martirosian, Petros

doi:10.1016/j.mri.2014.05.010

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…In our study, both T2 and T1rho measurements from conventional and UTE MR techniques generally increased with pathology, in agreement with past studies on other musculoskeletal tissues such as articular cartilage [6, 19]. To our knowledge, only one study [20] has previously reported quantitative T1 and T1rho values of the TFC discs and found a positive correlation with age. Quantitative MR, however, did not uniquely demonstrate abnormalities not seen with conventional sequences.…”

Section: Discussionsupporting

confidence: 92%

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

et al. 2015

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Objective To evaluate pathology of the triangular fibrocartilage complex (TFCC) using high resolution morphologic magnetic resonance (MR) imaging, and compare with quantitative MR and biomechanical properties. Materials and Methods Five cadaveric wrists (22 to 70 yrs) were imaged at 3T using morphologic (proton density weighted spin echo, PD FS, and 3D spoiled gradient echo, 3D SPGR) and quantitative MR sequences to determine T2 and T1rho properties. In eight geographic regions, morphology of TFC disc and laminae were evaluated for pathology and quantitative MR values. Samples were disarticulated and biomechanical indentation testing was performed on the distal surface of the TFC disc. Results On morphologic PD SE images, TFC disc pathology included degeneration and tears, while that of the laminae included degeneration, degeneration with superimposed tear, mucinous transformation, and globular calcification. Punctate calcifications were highly visible on 3D SPGR images and found only in pathologic regions. Disc pathology occurred more frequently in proximal regions of the disc than distal regions. Quantitative MR values were lowest in normal samples, and generally higher in pathologic regions. Biomechanical testing demonstrated an inverse relationship, with indentation modulus being high in normal regions with low MR values. The laminae studied were mostly pathologic, and additional normal samples are needed to discern quantitative changes. Conclusion These results show technical feasibility of morphologic MR, quantitative MR, and biomechanical techniques to characterize pathology of the TFCC. Quantitative MRI may be a suitable surrogate marker of soft tissue mechanical properties, and a useful adjunct to conventional morphologic MR techniques.

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Section: Discussionsupporting

confidence: 92%

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

et al. 2015

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“…11,12 Another recent report used biochemical MRI to assess degeneration of the disc proper in healthy volunteers. 13 The study found a significant difference in T2 values of the disc proper between subjects aged 30e50 years and subjects older than 50 years of age. These results suggested that increased T2 values of the disc proper reflect degeneration with aging.…”

Section: Discussionmentioning

confidence: 73%

High-resolution 3 T MRI of traumatic and degenerative triangular fibrocartilage complex (TFCC) abnormalities using Palmer and Outerbridge classifications

et al. 2017

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AIM: To investigate the usefulness of high-resolution 3 T magnetic resonance imaging (MRI) for the evaluation of traumatic and degenerative triangular fibrocartilage complex (TFCC) abnormalities among three groups: patients presenting with wrist pain who were (a) younger than age 50 years or (b) age 50 or older (PT<50 and PT!50, respectively), and (c) asymptomatic controls who were younger than age 50 years (AC).MATERIALS AND METHODS: High-resolution 3 T MRI was evaluated retrospectively in 96 patients, including 47 PT<50, 38 PT!50, and 11 AC. Two board-certified radiologists reviewed the MRI images independently. MRI features of TFCC injury were analysed according to the Palmer classification, and cartilage degeneration around the TFCC was evaluated using the Outerbridge classification. Differences in MRI findings among these groups were detected using chi-square test. Cohen's kappa was calculated to assess interobserver and intra-observer reliability.RESULTS: The incidence of Palmer class 1A, 1C and 1D traumatic TFCC injury was significantly (p<0.05) higher in PT!50 than in PT<50 (class 1A: 47.4% versus 27.7%, class 1C: 31.6% versus 12.8%, and class 1D: 21.1% versus 2.1%). Likewise, MRI findings of TFCC degeneration were observed more frequently in PT!50 than in PT<50 (p<0.01). Outerbridge grade 2 or higher cartilage degeneration was significantly (p<0.01) more frequently seen in PT!50 than in PT<50 (55.3% versus 17% in the lunate, 28.9% versus 4.3% in the triquetrum, 73.7% versus 12.8% in the ulna).CONCLUSION: High-resolution wrist MRI at 3 T enables detailed evaluation of TFCC traumatic injury and degenerative changes using the Palmer and Outerbridge classifications, with good or excellent interobserver and intra-observer reliability.Ó 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. Contents lists available at ScienceDirectClinical Radiology

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“…This sequence uses a relatively long minimum TE (14 ms in this study) and long TE spacing (> 10 ms), which can result in suboptimal sampling of the T2 decay curve. Other T2 quantification techniques, such as gradient echo with magnetization preparation [ 32 ] and double-echo steady-state [ 33 ] techniques, may be more sensitive to changes in short T2 components. These sequences take advantage of a shorter minimum TE (2 to 4 ms) and shorter TE spacing.…”

Section: Discussionmentioning

confidence: 99%

Quantitative magnetic resonance imaging of meniscal pathology ex vivo

et al. 2021

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Objective To determine the ability of conventional spin echo (SE) T2 and ultrashort echo time (UTE) T2* relaxation times to characterize pathology in cadaveric meniscus samples. Materials and methods From 10 human donors, 54 triangular (radially cut) meniscus samples were harvested. Meniscal pathology was classified as normal (n = 17), intrasubstance degenerated (n = 33), or torn (n = 4) using a modified arthroscopic grading system. Using a 3-T MR system, SE T2 and UTE T2* values of the menisci were determined, followed by histopathology. Effect of meniscal pathology on relaxation times and histology scores were determined, along with correlation between relaxation times and histology scores. Results Mean ± standard deviation UTE T2* values for normal, degenerated, and torn menisci were 3.6 ± 1.3 ms, 7.4 ± 2.5 ms, and 9.8 ± 5.7 ms, respectively, being significantly higher in degenerated (p < 0.0001) and torn (p = 0.0002) menisci compared to that in normal. In contrast, the respective mean SE T2 values were 27.7 ± 9.5 ms, 25.9 ± 7.0 ms, and 35.7 ± 10.4 ms, without significant differences between groups (all p > 0.14). In terms of histology, we found significant group-wise differences (each p < 0.05) in fiber organization and inner-tip surface integrity sub-scores, as well as the total score. Finally, we found a significant weak correlation between UTE T2* and histology total score (p = 0.007, Rs2 = 0.19), unlike the correlation between SE T2 and histology (p = 0.09, Rs2 = 0.05). Conclusion UTE T2* values were found to distinguish normal from both degenerated and torn menisci and correlated significantly with histopathology.

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Assessment of T1, T1ρ, and T2 values of the ulnocarpal disc in healthy subjects at 3 tesla

Cited by 11 publications

References 31 publications

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

MR morphology of triangular fibrocartilage complex: correlation with quantitative MR and biomechanical properties

High-resolution 3 T MRI of traumatic and degenerative triangular fibrocartilage complex (TFCC) abnormalities using Palmer and Outerbridge classifications

Quantitative magnetic resonance imaging of meniscal pathology ex vivo

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