2012
DOI: 10.1016/s1470-2045(11)70333-3
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Assessment of symptomatic women for early diagnosis of ovarian cancer: results from the prospective DOvE pilot project

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Cited by 133 publications
(125 citation statements)
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“…This suggests that in Type II iEOC a symptom‐based intervention is more likely to influence tumour volume than impact on stage. This is supported by the recent prospective study (DOvE study; Diagnosing Ovarian Cancer Early)38 where CA125 testing and transvaginal ultrasound in women with ovarian cancer symptoms resulted in detection of lower volume disease in women with high‐grade serous ovarian cancers 39. Diagnosis at lower tumour volumes is likely to improve the surgeon's ability to achieve zero residual disease at surgery, a key prognostic factor in disease survival 40.…”
Section: Discussionmentioning
confidence: 89%
“…This suggests that in Type II iEOC a symptom‐based intervention is more likely to influence tumour volume than impact on stage. This is supported by the recent prospective study (DOvE study; Diagnosing Ovarian Cancer Early)38 where CA125 testing and transvaginal ultrasound in women with ovarian cancer symptoms resulted in detection of lower volume disease in women with high‐grade serous ovarian cancers 39. Diagnosis at lower tumour volumes is likely to improve the surgeon's ability to achieve zero residual disease at surgery, a key prognostic factor in disease survival 40.…”
Section: Discussionmentioning
confidence: 89%
“…Nevertheless, early diagnosis could still improve outcomes for ovarian cancer. For example, the majority of high-grade serous ovarian cancers (HGSCs) (which are included in type II epithelial ovarian cancers; responsible for the majority of all ovarian cancer mortality (Brown and Palmer, 2009)) originate outside the ovaries, spreading to the ovaries as they progress (Gilbert et al, 2012). This results in these tumours becoming advanced-stage early in their development (Cho and Shih, 2009).…”
mentioning
confidence: 99%
“…The late-stage cases that were detected had smaller, more resectable tumour volumes, with a larger pro- portion showing disease localized to the fallopian tube instead of having ovary involvement. 21 Findings from this study emphasize the need to detect disease at more resectable, lower volumes. 21 A 2010 publication showed that advanced cases of serous carcinoma (type 2) had a shorter duration of symptoms compared with mucinous carcinoma (type 1).…”
Section: Discussionmentioning
confidence: 71%
“…21 Findings from this study emphasize the need to detect disease at more resectable, lower volumes. 21 A 2010 publication showed that advanced cases of serous carcinoma (type 2) had a shorter duration of symptoms compared with mucinous carcinoma (type 1). 22 This suggests that the late-stage diagnosis of serous carcinoma cases is likely due to rapid progression rather than delay in detection.…”
Section: Discussionmentioning
confidence: 71%