Assessment of strain and strain rate by two-dimensional speckle tracking in mice: comparison with tissue Doppler echocardiography and conductance catheter measurements

Ferferieva, Vesselina; Bergh, An Van Den; Claus, Piet; Jasaitytė, Rūta; Gerche, André La; Rademakers, Frank; Herijgers, Paul; D'hooge, Jan

doi:10.1093/ehjci/jes274

Cited by 33 publications

(25 citation statements)

References 34 publications

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“…Strain values, on the other hand, are still considered adequate at lower frequencies. 27,28 Lower FRs could also have an influence on the feasibility, although this was not different in the current series than in previous reports. 29 Furthermore, although deformation analysis was performed on DICOM images using vendor-independent software, Koopman et al previously showed good correlation with vendor-specific software used for longitudinal strain analysis.…”

Section: <00001contrasting

confidence: 76%

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

et al. 2014

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Section: <00001contrasting

confidence: 76%

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

et al. 2014

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“…[13][14][15] Furthermore, there are limited data on the effect of loading conditions on 2D strain and SR. To date, the only accepted method able to generate load-independent parameters of ventricular function is the conductance catheter method. There have been conflicting results regarding the load sensitivity of the strain and SR of the RV when measured by Doppler 16 and speckle tracking studies.…”

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confidence: 99%

Two-Dimensional Global Longitudinal Strain Rate Is a Preload Independent Index of Systemic Right Ventricular Contractility in Hypoplastic Left Heart Syndrome Patients After Fontan Operation

Schlangen

Petko

Hansen

et al. 2014

Circ: Cardiovascular Imaging

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Background— Assessment of systemic right ventricular (RV) function in patients with hypoplastic left heart syndrome is important during long-term follow-up after Fontan repair. Traditional echocardiographic parameters to evaluate systolic ventricular function are affected by loading conditions. The only generally accepted load-independent parameter of systolic function, end systolic elastance ( E es ), requires invasive catheterization. Therefore, we sought to determine if parameters obtained by 2-dimensional speckle tracking (2DST) were affected by acute changes in preload and correlated with catheterization-derived indices of RV contractility in hypoplastic left heart syndrome patients after Fontan palliation. Methods and Results— Fifty-two patients with hypoplastic left heart syndrome (median age, 6.6; range 2.9–22.2 years) were prospectively enrolled to have echocardiography and conductance catheter studies performed simultaneously. We compared traditional echo, 2-dimensional speckle tracking and catheterization-derived parameters during different states of preload at baseline and during dobutamine infusion. Global longitudinal strain (S) showed a tendency to decrease with preload reduction, whereas global longitudinal strain rate (SR) did not change (S: −17.7±3.4% versus −16.9±3.8%, P =0.08; SR: −1.30±0.29 versus −1.34±0.34 s −1 , P =0.3). S did not change with dobutamine infusion (−17.7±3.4% versus −18.4±3.9%, P =0.24), whereas SR increased significantly (−1.30±0.29 versus −2.26±0.49 s −1 , P <0.001). RV E es correlated with SR ( r s = −0.47, P <0.001), but not with S ( r s =0.07, P =0.5) or other echocardiographic parameters. Conclusions— In contrast to S, SR was not affected by preload and correlated with E es of the systemic RV. SR may be a useful noninvasive surrogate of RV contractility and suitable for follow-up of patients with hypoplastic left heart syndrome after Fontan palliation.

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“…Peak systolic values of radial SR in the anterior and posterior wall were obtained using Tissue Doppler Imaging (TDI) as previously described (Derumeaux et al, 2008). TDI loops were acquired from the same parasternal view with a careful alignment with the radial component of the deformation (Ferferieva et al, 2013) at a mean frame rate of 514 fps and a depth of 1 cm. The Nyquist velocity limit was set at 12 cm/s.…”

Section: Discussionmentioning

confidence: 99%

Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity

Prola

Blondelle

Vandestienne

et al. 2019

Preprint

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The tubular shape of mitochondrial cristae depends upon a specific composition of the inner mitochondrial membrane, including cardiolipin that allows strong curvature and promotes optimal organization of ATP synthase. Here we identify Hacd1, which encodes an enzyme involved in very long chain fatty acid biosynthesis, as a key regulator of composition, structure and functional properties of mitochondrial membranes in muscle. In Hacd1-deficient mice, the reduced cardiolipin content was associated with dilation of cristae and caused defective phosphorylating respiration, characterized by absence of proton leak and oxidative stress.The skeletal muscle-specific mitochondrial coupling defect produced a global elevation in basal energy expenditure with increased carbohydrate and lipid catabolism, despite decreased muscle mass and locomotor capacities. Mice were protected against diet-induced obesity despite reduced muscle activity, providing an in vivo proof of concept that reducing mitochondrial coupling efficiency in skeletal muscle might be an actionable mechanism in metabolic disease conditions.

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Assessment of strain and strain rate by two-dimensional speckle tracking in mice: comparison with tissue Doppler echocardiography and conductance catheter measurements

Cited by 33 publications

References 34 publications

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

Two-Dimensional Global Longitudinal Strain Rate Is a Preload Independent Index of Systemic Right Ventricular Contractility in Hypoplastic Left Heart Syndrome Patients After Fontan Operation

Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity

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