This paper aims to design a sting support system for a transonic wind tunnel test for a commercial wide-bodied aircraft, which includes a single sting and a blade support. Parameters of the sting support system have been analyzed and three key parameters are selected for optimization. A RANS solver has been developed to investigate the effects of key parameters on the sting support interference. Influences of four incidence angles and five locations of an expanding point on the single sting interference are studied, and also the effects of six vane leading edge sweep angles on the blade support interference are investigated. The optimal key parameters are determined, based on numerical results and structural rigidity. Structural intensity verification of the optimized support system has been performed under the estimated aerodynamic loading by commercial software. Results indicate that a 6° incidence angle and 03 expanding point are the optimal parameters for a single sting and a 50° leading edge sweep angle of the vane is optimal for blade support. The optimized sting system with sufficient safety factors is suitable for commercial wide-bodied aircraft wind tunnel tests, which implies the method in this paper can be used to optimize the sting support system of other vehicles.