Assessment of Sonographic Carotid Parameters in Autism Spectrum Disorder: A Comparative Case Control Study

Yetkin, Duygu Imre; Sizer, E; Gökhaner, Yurdagül Tolu; Büyükdemirci, Erkan; Atlı, Abdullah

doi:10.1080/17518423.2023.2181417

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…Related studies have shown that children with ASD have higher levels of homocysteine (HCY) ( 56 ), which are positively correlated with carotid artery intima-media thickness (CA-IMT), atherogenic index, left ventricular mass index (LVMI), and blood pressure ( 57 ) and are also strongly associated with the severity of heart failure ( 58 ). In addition, Imre Yetkin et al ( 59 ) found that Childhood Autism Rating Scale (CARS) scores were positively correlated with vessel diameter, carotid intima-media thickness (cIMT), and intima-media thickness/diameter ratio (IDR) values in children with ASD, suggesting that CVD risk may increase with the severity of ASD. These pieces of evidence support ASD as a potential risk factor for CVD, which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

A Mendelian randomization study of the effect of mental disorders on cardiovascular disease

Yu,

Yang,

et al. 2024

Front. Cardiovasc. Med.

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ObjectiveThe effect of mental disorders (MD) on cardiovascular disease (CVD) remains controversial, and this study aims to analyze the causal relationship between eight MD and CVD by Mendelian randomization (MR).MethodsSingle nucleotide polymorphisms of attention-deficit/hyperactivity disorder (ADHD), anorexia nervosa (AN), anxiety disorder (ANX), autism spectrum disorder (ASD), bipolar disorder (BD), depression, obsessive-compulsive disorder (OCD), schizophrenia (SCZ), and CVD were obtained from UK Biobank and FinnGen. Exposure-outcome causality was tested using inverse variance weighted (IVW), MR-Egger, and weighted median. Horizontal pleiotropy and heterogeneity were assessed by MR-Egger intercept and Cochran's Q, respectively, while stability of results was assessed by leave-one-out sensitivity analysis.ResultsMR analysis showed that ANX (IVW [odds ratio (OR) 1.11, 95% confidence intervals (CI) 1.07–1.15, p < 0.001]; MR-Egger [OR 1.03, 95% CI 0.92–1.14, p = 0.652]; weighted median [OR 1.09, 95% CI 1.03–1.14, p = 0.001]), ASD (IVW [OR 1.05, 95% CI 1.00–1.09, p = 0.039]; MR-Egger [OR 0.95, 95% CI 0.84–1.07, p = 0.411]; weighted median [OR 1.01, 95% CI 0.96–1.06, p = 0.805]), depression (IVW [OR 1.15, 95% CI 1.10–1.19, p < 0.001]; MR-Egger [OR 1.10, 95% CI 0.96–1.26, p = 0.169]; weighted median [OR 1.13, 95% CI 1.08–1.19, p < 0.001]) were significantly associated with increased risk of CVD, whereas ADHD, AN, BD, OCD, and SCZ were not significantly associated with CVD (p > 0.05). Intercept analysis showed no horizontal pleiotropy (p > 0.05). Cochran's Q showed no heterogeneity except for BD (p = 0.035). Sensitivity analysis suggested that these results were robust.ConclusionsANX, ASD, and depression are associated with an increased risk of CVD, whereas AN, ADHD, BD, OCD, and SCZ are not causally associated with CVD. Active prevention and treatment of ANX, ASD, and depression may help reduce the risk of CVD.

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