Assessment of Some Bone Turnover in Chronic Kidney Disease Patients in Tikrit/Iraq

Abstract

The present study aimed to assess some bone turnover in chronic kidney disease with and without hemodialysis. 50 individuals were involved in the study and divided into three groups; the first two groups were patients with chronic kidney disease (15 were with hemodialysis, and 15 were without hemodialysis), and the third group involved 20 healthy individuals as a control group. Some bone turnovers like parathyroid hormone, vitamin D3, insulin-like growth factor-1, osteopontin, fibroblast growth factor-23, and calprotectin were analyzed using serum from all individuals. The serum concentration of parathyroid hormone was significantly lower (P>0.05) in chronic kidney disease with non-hemodialysis compared to chronic kidney disease with hemodialysis group and healthy individuals. While serum concentrations of vitamin D3, insulin-like growth factor, and osteopontin were significantly lower in both chronic kidney disease groups compared to healthy individuals. The serum concentration of fibroblast growth factor showed a non-significant difference (P<0.05) in both chronic kidney disease groups compared to healthy individuals. While serum concentration of calprotectin showed a significant increase (P>0.05) only in the chronic kidney disease without hemodialysis group compared to both other groups.