Assessment of Sleep Disturbances and Exhaustion in Mothers of Children With Atopic Dermatitis

Ramirez, Faustine D.; Chen, Shelley; Langan, Sinéad; Prather, Aric A.; McCulloch, Charles E.; Kidd, Sharon A.; Cabana, Michael D.; Chren, Mary Margaret; Abuabara, Katrina

doi:10.1001/jamadermatol.2018.5641

Cited by 32 publications

(38 citation statements)

References 48 publications

(94 reference statements)

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“…Analysis of the cohort data from 11,649 mother-child pairs who were followed up with a time-varying measure of child AD activity and severity as well as self-reported maternal sleep measures repeated at multiple time points for children aged 6 months to 11 years showed that mothers of children with AD reported difficulty falling asleep, subjectively insufficient sleep, and daytime exhaustion throughout the first 11 years of childhood. 13,14 These data suggest that sleep disturbance may be a family affair.…”

Section: Practice Pointsmentioning

confidence: 87%

“…12 The well-being and development of children are strongly influenced by the physical and psychosocial health of parents/guardians. Two studies by Ramirez and colleagues 13,14 published in 2019 examined sleep disturbances and exhaustion in mothers of children with AD. Data for the studies came from the Avon Longitudinal Study of Parents and Children.…”

Section: Practice Pointsmentioning

confidence: 99%

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Update on Pediatric Atopic Dermatitis

Tracy¹,

Bhatti²,

Eichenfield³

2020

Cutis

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WWW.MDEDGE.COM/DERMATOLOGY CLINICAL REVIEW Recent studies have led to new insights into atopic dermatitis (AD) pathogenesis and epidemiology as well as its impact on the quality of life of affected children and adolescents. In addition, there are several novel topical and systemic agents recently approved and in late-stage clinical development programs. Epidemiologic insights include relative prevalence rates in different countries and studies of subsets of pediatric patients with different disease longevity and persistence. Studies on quality of life have shown tremendous impact on sleep, not only in affected individuals but in their parents/guardians. The impact of bathing regimens is discussed. Newer topical therapies are reviewed, including topical crisaborole, with a new indication for infants as young as 3 months of age. Topical Janus kinase (JAK) inhibitors are being developed, with some studies including adolescents and children. Other novel therapies include the topical aryl hydrocarbon receptor agonist tapinarof and oral JAK inhibitors; adolescents are being included in the initial clinical trials for several of these therapies. Dupilumab, the first biologic agent approved for AD, has now been well studied in patients aged 6 years and older, with expanded indication down to 6 years of age.

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Section: Practice Pointsmentioning

confidence: 87%

Section: Practice Pointsmentioning

confidence: 99%

Update on Pediatric Atopic Dermatitis

Tracy¹,

Bhatti²,

Eichenfield³

2020

Cutis

View full text Add to dashboard Cite

show abstract

“…22,32 The bedtime routine module focused on establishing and implementing a consistent bedtime routine. 6,8,9,12,18 A template was provided for participants to build their personalized bedtime routine, including activities they must do to prepare for bed (ie brush teeth, put on pajamas) and activities that help them relax (ie read, quiet music). Bedtime routine goals focused on the implementation process of the bedtime routine, ranging from trialing (and possibly revising) a new bedtime routine, increasing the number of nights the bedtime routine is used, and choosing consistent time to start the routine.…”

Section: Skip Developmentmentioning

confidence: 99%

“…Sleep quality goals included establishing a consistent bedtime and/or wake time, use of bed for sleep only, and bedtime relaxation (progressive relaxation, belly breathing). 12,19,22,23,34,35 Goals related to sleep quantity were based on the National Sleep Foundation's age-specific sleep duration recommendations. 36…”

Section: Skip Developmentmentioning

confidence: 99%

“…2 Although some parent sleep disturbances are attributed to frequent awakenings to attend to their child's nighttime needs, parents may also experience bedtime variability and sleep-related anxiety caused by either their child's asthma and/or the related child sleep problems. [12][13][14][15] Inadequate amount of sleep and/or poor-quality sleep in parents has been associated with poorer quality of life, decreased work productivity, stress, depression, and anxiety. 16,17 Although common, behavioral sleep disturbances are also modifiable.…”

Section: Introductionmentioning

confidence: 99%

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Sleep intervention for children with asthma and their parents (SKIP Study): a novel web-based shared management pilot study

Sonney

Thompson

Landis

et al. 2020

Journal of Clinical Sleep Medicine

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Study Objectives: The objective of this study was to describe the feasibility, acceptability, and preliminary efficacy of a novel Sleep Intervention for Kids and Parents (SKIP). Parent and child primary sleep outcomes were total sleep time, wake after sleep onset (WASO), sleep efficiency (SE), and bedtime range. Methods: Children 6-11 years of age with asthma and 1 parent, both with behavioral sleep disturbance, enrolled in this single-group pilot. The 8-week shared management intervention included weekly online educational modules, goal setting, and progress reporting. Feasibility was measured by the number of dyads who were eligible, enrolled, and retained. Acceptability was measured by survey and semistructured interview. Total sleep time, WASO, SE, and bedtime range were measured by actigraphy at baseline, after the intervention, and 12-week follow-up. Mixed-effects regression models were used to determine change in sleep outcomes from baseline. Results: Thirty-three of 39 eligible dyads enrolled; of 29 dyads that started the intervention, 25 (86%) completed all study visits. SKIP was acceptable for 61% of children and 92% of parents. Compared with baseline, at follow-up, children had significantly improved WASO (−37 minutes; 95% confidence interval [CI],

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TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children

Shi

Tao

et al. 2022

Clinical Laboratory Analysis

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Atopic dermatitis (AD), also known as eczema, is the most common chronic inflammatory skin disease, adversely affecting 10%-20% of the pediatric population worldwide. 1 The disorder, characterized by intense itching and recurrent eczematous lesions, seriously reduces pediatric patients' quality of life and increases health care burden. 2,3 Although the exact pathophysiology of AD remains unclear, genetic predisposition, immune dysregulation, and epidermal barrier dysfunction have been thought to be the critical factors in the pathogenesis and development of AD. 1,4,5

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Assessment of Sleep Disturbances and Exhaustion in Mothers of Children With Atopic Dermatitis

Abstract: This longitudinal cohort study analyzes data collected across 11 years to assess the association between the presence and severity of atopic dermatitis in children and maternal sleep disturbance among a population-based UK cohort of mother-child pairs.

Cited by 32 publications

References 48 publications

Update on Pediatric Atopic Dermatitis

Update on Pediatric Atopic Dermatitis

Sleep intervention for children with asthma and their parents (SKIP Study): a novel web-based shared management pilot study

TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children

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