Assessment of Single Nucleotide Polymorphism at IL‐1A+4845 and IL‐1B+3954 as Genetic Susceptibility Test for Chronic Periodontitis in Maharashtrian Ethnicity

Agrawal, Amit; Kapley, Atya; Yeltiwar, Ramreddy K; Purohit, Hemant J.

doi:10.1902/jop.2006.050427

Cited by 47 publications

(44 citation statements)

References 39 publications

(52 reference statements)

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“…The disease has been noted to occur naturally with increasing age in humans and nonhuman primates (9)(10)(11)(12). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (13), environmental stressors (14,15), and the genetic backgrounds of the individuals studied (3,16,17).…”

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confidence: 99%

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

Ebersole

Holt

Delaney

2013

Clin. Vaccine Immunol.

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The acquisition and development of the complex oral microbiome remain ill defined. While selected species of oral bacteria have been examined in relation to their initial colonization in neonates, a more detailed understanding of the dynamics of the microbiome has been developed only in adults. The current investigation used a nonhuman primate model to document the kinetics of colonization of the oral cavities of newborns and infants by a range of oral commensals and pathogens. Differences in colonization were evaluated in newborns from mothers who were maintained on an oral hygiene regimen pre-and postparturition with those displaying naturally acquired gingivitis/periodontitis. The results demonstrate distinct profiles of acquisition of selected oral bacteria, with the transmission of targeted pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, being passed on primarily from mothers with gingivitis/periodontitis. This colonization resulted in defined patterns of systemic antibody responses in the infants. The significant relative risk measures for infection with the pathogens, as well as the relationship of oral infection and blood serum antibody levels, were consistent with those of the newborns from mothers with gingivitis/periodontitis. These findings indicate that the early acquisition of potentially pathogenic oral bacterial species might impact the development of mucosal responses in the gingiva and may provide an enhanced risk for the development of periodontitis later in life.

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confidence: 99%

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

Ebersole

Holt

Delaney

2013

Clin. Vaccine Immunol.

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“…This oral disease is an outcome of complex oral infections, chronic immunoinflammatory responses, and resulting destruction of soft and hard tissues of the periodontium (37,78,80,82,84). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (48), environmental stressors (6,76,85), and the genetic backgrounds of the individuals (3,70,84).…”

mentioning

confidence: 99%

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Ebersole

Steffen

González‐Martínez

et al. 2008

Clin Vaccine Immunol

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This report evaluated systemic inflammatory and immune biomarkers in a cohort of Macaca mulatta (rhesus monkeys) maintained as a large family social unit, including an age range from <1 year to >24 years. We hypothesized that the systemic host responses would be affected by the age, gender, and clinical oral presentation of the population, each contributing to inflammatory and immune responses that would reflect chronic oral infections. The results demonstrated that the prevalence and severity of periodontitis, including missing teeth, increased significantly with age. Generally, minimal differences in clinical parameters were noted between the genders. Systemic inflammatory mediators, including acute-phase reactants, prostaglandin E 2 (PGE 2 ), cytokines/chemokines, and selected matrix metalloproteinases (MMP), demonstrated significant differences among the various age groups of animals. Levels of many of these were increased with age, although PGE 2 , RANTES, bactericidal permeability-inducing factor (BPI), MMP-1, and MMP-9 levels were significantly increased in the young group (ϳ1 to 3 years old) relative to those for the older animals. We observed that in the adult and aged animals, levels of the systemic inflammatory mediators related to gingival inflammation and periodontal tissue destruction were significantly elevated. Serum antibody levels in response to a battery of periodontal pathogens were generally lower in the young animals, <50% of those in the adults, and were significantly related to aging in the cohort. The levels of antibodies, particularly those to Porphorymonas gingivalis, Fusobacterium nucleatum, and Tannerella forsythia, were most significantly elevated in animals with periodontal disease, irrespective of the age of the animal. These results provide a broad description of oral health and host responses in a large cohort of nonhuman primates from very young animals to the aged of this species. The findings afford a base of data with which to examine the ontogeny of host responses at mucosal sites, such as the gingival tissues.Periodontal disease is the predominant chronic inflammatory disease of humanity (37,38,78,82) and has been noted to occur naturally with increasing age in humans and nonhuman primates (36,63,69,88). This oral disease is an outcome of complex oral infections, chronic immunoinflammatory responses, and resulting destruction of soft and hard tissues of the periodontium (37,78,80,82,84). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (48), environmental stressors (6, 76, 85), and the genetic backgrounds of the individuals (3, 70, 84).The oral microbial characteristics of subgingival biofilms in younger and older individuals demonstrate differences in composition and complexity, which have been suggested to contribute directly to the microbial infections that trigger the destructive disease of oral tissues that occurs during aging (4,35,49,...

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“…Drozdzik et al (38) found no significant association between the presence of the IL-1B polymorphism (+3953) and the periodontal status of patients, consistent with the present study, describing plaque index and age as more influential risk factors. By contrast, Agrawal et al (39) reported that the presence of IL-1 gene polymorphisms is a clear risk factor for chronic PD, finding significant differences between healthy non-smokers and non-smoking patients with severe chronic PD. A recent review by Huynh-Ba et al (40) reflected the discrepancies among published clinical findings and concluded that the evidence on the contribution of IL-1 gene polymorphisms on PD progression was inadequate.…”

Section: Discussionmentioning

confidence: 89%

Interleukin-1 gene polymorphisms and periodontal status in a Spanish population

et al. 2012

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Abstract. The aim of this study was to investigate the possible association between interleukin (IL)-1A (+4845) and/or IL-1B (+3954) gene polymorphisms and the onset and progression of chronic periodontal disease (PD), an issue that remains controversial. The relationship between IL-1β concentration in the gingival crevicular fluid (GCF) and disease activity was also evaluated. The study was performed on 25 individuals with no gingivitis or PD and on 25 subjects with active chronic PD. Two samples of GCF were obtained from each subject and IL-1β was determined by enzyme-linked immunoabsorbent assay. Blood samples (10 ml) were drawn from each subject to detect polymorphisms in IL-1A (+4845) and IL-1B (+3954) by polymerase chain reaction. Mean GCF IL-1β concentrations were higher in patients with active chronic PD compared to the control group. No significant association was found in either group between GCF IL-1β concentration and the presence of polymorphisms in IL-1A (+4845), IL-1B (+3954) or both genotypes. No significant difference was found in either group with regard to the presence of polymorphisms in IL-1A (+4845), IL-1B (+3954) or both genotypes (p=0.556). The concentration of IL-1β in GCF was almost 2-fold higher in patients with chronic PD than in the healthy individuals. The presence of polymorphisms in IL-1A (+4845) and/or IL-1B (+3954) genotypes is not associated with IL-1β overproduction in GCF and is not a risk factor for chronic PD. IL-1β is considered a suitable marker of the severity and progression of chronic PD. The presence of IL-1A (+4845) and/or IL-1B +3954 gene polymorphisms does not appear to be a risk factor for chronic PD. Therefore, the IL-1A (+4845) and/or IL-1B +3954 gene polymorphisms cannot be considered genetic markers of chronic PD. Moreover, these polymorphisms do not indicate an overproduction of IL-1β in GCF.

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Assessment of Single Nucleotide Polymorphism at IL‐1A+4845 and IL‐1B+3954 as Genetic Susceptibility Test for Chronic Periodontitis in Maharashtrian Ethnicity

Abstract: Results of the present study reinforced the association of the IL-1 genotype as a risk factor for severe chronic periodontitis. Positivity for the composite genotype was found to be significantly associated with severe chronic periodontitis (odds ratio [OR]=12.42).

Cited by 47 publications

References 39 publications

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Interleukin-1 gene polymorphisms and periodontal status in a Spanish population

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