Assessment of severity of acute pancreatitis in a Sars-CoV-2 pandemia

Chiarello, Maria Michela; Cariati, Maria; Brisinda, Giuseppe

doi:10.1002/bjs.11818

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…According to Chiarello et al [ 26 ], AP with concomitant COVID-19 can be associated with a worse prognosis due to a double pulmonary injury (directly by a virus, and indirectly by cytokine storm secondary to AP). The authors noted that in severe AP, lung involvement was common, and it could lead to severe ARDS.…”

Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

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Association between acute pancreatitis and COVID-19 infection: What do we know?

Jabłońska

Mrowiec

2021

WJGS

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The disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called coronavirus disease 2019 (COVID-19), first originated in Wuhan, China, displaying atypical pneumonia-like respiratory symptoms in affected patients. SARS-CoV-2 primarily attacks the respiratory system, and the most common symptoms include cough, shortness of breath, and fever. However, its impact on the digestive system has been shown, and various clinical gastrointestinal manifestations of this disease have been recognized. Some reports have shown acute pancreatitis (AP) as the initial symptom in patients with COVID-19. AP may be a consequence of direct pancreatic damage by the virus because pancreatic acinar cells contain angiotensin-converting enzyme 2 receptor proteins, and SARS-CoV-2 can bind to these receptors, causing pancreatic injury. Moreover, AP may be a secondary indicator of cytokine storms and altered inflammatory responses. Our review of the literature shows that SARS-CoV-2 appears to be a new etiological infectious factor related to AP. In this manuscript, a comprehensive review of case reports and case series of patients with AP and COVID-19 is presented. All reports on COVID-19-associated AP are summarized. All cases are thoroughly analyzed and discussed in-depth.

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Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

“…In COVID-19 pneumonia, a ground-glass sign is common, as pleural effusion and alveolar involvement are later radiological signs. In COVID-19 disease, there are segmentary micro-embolisms that are not present in ARDS[ 26 ].…”

Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

Association between acute pancreatitis and COVID-19 infection: What do we know?

Jabłońska

Mrowiec

2021

WJGS

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“…The predominant organ dysfunction was respiratory failure in the majority of COVID-19 positive patients. In addition, acute pancreatitis with concomitant SARS-CoV-2 was more likely to have poorer outcomes due to double pulmonary damage[ 40 ]. Lung involvement is common in severe acute pancreatitis.…”

Section: What Do We Know About Acute Pancreatitis In Covid-19 Positiv...mentioning

confidence: 99%

“…Lung involvement is common in severe acute pancreatitis. This involvement can progress to full blown acute respiratory distress syndrome[ 40 ]. At present, it could be difficult to stratify the severity of symptoms and the degree of lung involvement.…”

Section: What Do We Know About Acute Pancreatitis In Covid-19 Positiv...mentioning

confidence: 99%

SARS-CoV-2 and the pancreas: What do we know about acute pancreatitis in COVID-19 positive patients?

Brisinda¹,

Chiarello²,

Tropeano³

et al. 2022

World J Gastroenterol

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause pancreatic damage, both directly to the pancreas via angiotensin-converting enzyme 2 receptors (the transmembrane proteins required for SARS-CoV-2 entry, which are highly expressed by pancreatic cells) and indirectly through locoregional vasculitis and thrombosis. Despite that, there is no clear evidence that SARS-CoV-2 is an etiological agent of acute pancreatitis. Acute pancreatitis in coronavirus disease 2019 (COVID-19) positive patients often recognizes biliary or alcoholic etiology. The prevalence of acute pancreatitis in COVID-19 positive patients is not exactly known. However, COVID-19 positive patients with acute pancreatitis have a higher mortality and an increased risk of intensive care unit admission and necrosis compared to COVID-19 negative patients. Acute respiratory distress syndrome is the most frequent cause of death in COVID-19 positive patients and concomitant acute pancreatitis. In this article, we reported recent evidence on the correlation between COVID-19 infection and acute pancreatitis.

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“…As reported in the literature, the authors document a greater use of computed tomography (CT) scan of the abdomen during the COVID period. The authors also underline the need to perform a CT scan of the chest, for a more appropriate evaluation of patients, as suggested also for other urgent diseases [ 3 ].…”

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confidence: 99%