Assessment of Serum Vitamin D Levels in the serum of Patients with Postherpetic neuralgia and its correlation to pain severity: A cross‐sectional comparative study

Seetan, Khaled; Al-Bashir, Sharaf M.; Jarrar, Bashar; Aldebei, Asem; Shatanawi, Murad; Serhan, Hashem Abu; Irshedat, Sara

doi:10.1111/ijcp.14750

Cited by 3 publications

(4 citation statements)

References 49 publications

(92 reference statements)

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“…In our study, we found a significant decrease in serum vitamin D levels in patients with PHN, which is consistent with Seetan et al's findings 44 . They stated that low vitamin D levels are associated with the risk of PHN incidence in the elderly with chronic pain.…”

Section: Discussionsupporting

confidence: 93%

“…43 In our study, we found a significant decrease in serum vitamin D levels in patients with PHN, which is consistent with Seetan et al's findings. 44 They stated that low vitamin D levels are associated with the risk of PHN incidence in the elderly with chronic pain. Starting vitamin D supplementation in patients with HZ may reduce the likelihood of subsequent PHN, suggesting that vitamin D may have a protective effect on severe neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and inflammatory biomarkers in herpes zoster

Oskay

Keskin

Özen

2022

Journal of Medical Virology

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The risk of herpes zoster (HZ) increases as cell-mediated immunity declines with age.Even though oxidative stress plays a crucial role in the development of HZ, there are few serum biomarkers of the disease's antioxidant activity. The purpose of this study is to investigate the blood levels of major antioxidants in HZ patients. To the best of our knowledge, this is the first study on this issue in the literature. The serum levels of antioxidants including uric acid (UA), total bilirubin (TBİL), albumin (ALB), vitamin D levels, and inflammatory markers such as homocysteine (Hcy) and C-reactive protein (CRP) was retrospectively analyzed in 53 patients with HZ and 53 age-and sex-matched healthy controls (HCs). The relationships between these markers and postherpetic neuralgia (PHN) and the clinical severity of HZ were also evaluated.Serum levels of UA, TBIL, and ALB in patients with HZ were significantly lower than those in the HCs (p < 0.001), while no statistical differences were found in vitamin D levels between the groups. Hcy and CRP levels were significantly increased in HZ patients compared to HCs. Significant differences were observed in the serum levels of UA, Hcy, CRP, and vitamin D in the PHN group versus the non-PHN group (p < 0.001). The presence of inflammatory markers was found to be positively related to disease activity. Furthermore, when compared to the mild or moderate clinical types of HZ, these biomarkers were statistically significant in the severe clinical type.These results suggest that uncontrolled varicella-zoster virus reactivation, acute nerve damage, and PHN may all be associated with low antioxidant levels. These biomarkers may be a protective factor for HZ, but more research is needed to clarify the underlying mechanism.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Antioxidant and inflammatory biomarkers in herpes zoster

Oskay

Keskin

Özen

2022

Journal of Medical Virology

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“…[65][66][67] Insufficient levels of Vitamin D are associated with PHN. 47,68,69 Vitamin D is essential for the growth, survival, and proliferation of neurons, making it a potential therapeutic option for various neurodegenerative diseases. [70][71][72] In patients with HZ, Vitamin D supplementation may reduce the likelihood of subsequent PHN, indicating that it could have a protective effect against severe neuroinflammation 47,73,74 Lastly, in their study, Oskay et al discovered that there is a significant positive correlation between the levels of Hcy in severe HZ rashes and the development of PHN.…”

Section: Dovepressmentioning

confidence: 99%

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Xú¹,

Xu²,

Gong³

et al. 2023

JMDH

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Background Herpes zoster (HZ) is a skin disease that can also cause virus-infectious peripheral neuropathies. Despite this, there is limited information on patient preferences for seeking medical attention for HZ and zoster-associated pain (ZAP). Our study aimed to evaluate how frequently patients with ZAP choose to visit neurologists for their symptoms. Methods This study conducted a retrospective review of electronic health records in three general hospitals from January 2017 to June 2022. Using association rule mining, the study analyzed referral behaviors. Results We identified 33,633 patients with 111,488 outpatient visits over 5.5 years. The study found that the majority of patients (74.77–91.22%) visited dermatologists during their first outpatient visit, while only a small percentage (0.86–1.47%) preferred to consult a neurologist. The proportion of patients referred to a specialist during their medical visit varied significantly between different specialties within the same hospital (p <0.05) and even within the same specialty (p<0.05). There was a weak association (Lift:1.00–1.17) of referral behaviors between dermatology and neurology. Across the three hospitals, the average number of visits to a neurologist for ZAP was 1.42–2.49, with an average electronic health record duration of 11–15 days per patient. After consulting with a neurologist, some patients were referred to other specialists. Conclusion It was observed that patients with HZ and ZAP tended to visit a variety of specialists, with only a small number seeking the assistance of neurologists. However, from the perspective of neuroprotection, it is the duty of neurologists to provide more means.

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“…Vitamin D is a steroid, functioning as a hormone in the human body and having a role in glucose homeostasis and sensitivity to insulin There was evidence for an association between lower serum 25(OH)D levels and higher prevalence of DPN in individuals with obesity [46]; however, there was no evidence to support the causal association of serum 25(OH)D levels with diabetic neuropathy [47]. Studies also indicated important roles of vitamin D in postherpetic neuralgia (PHN) [48], multiple myeloma [49], CIPN [50], carpal tunnel syndrome (CTS) [50], and plexiform neurofibromas (PNFs) [51]. Patients with these diseases have high prevalence of vitamin D deficiency.…”

Section: Vitamin Dmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

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Purpose of review Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

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Assessment of Serum Vitamin D Levels in the serum of Patients with Postherpetic neuralgia and its correlation to pain severity: A cross‐sectional comparative study

Cited by 3 publications

References 49 publications

Antioxidant and inflammatory biomarkers in herpes zoster

Antioxidant and inflammatory biomarkers in herpes zoster

Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Vitamins in neuropathy: pathophysiological and therapeutic roles

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