Assessment of Serum Prolactin in Hypothyroidism Infertile Females, in Whitenilestate, Sudan

Abstract

Background: Thyroid dysfunction is a public health problem in White Nile State in Sudan. It is majorly caused by iodine deficiency. Hyperprolactinemia, the clinical condition associated with infertilityis resulted from a number of causes. Objectives: This study aimed to assess the relationship between thyroid hormone and prolactin serum level in Sudanese hypothyroidism infertile females. Material and Method: One hundred Sudanese females with hypothyroidism were compared with eightys healthy control. Blood samples were collected after an overnight fasting. Serum TSH, T3, T4 were analyzed using fully automated immunoassay analyzer system (AIA)TOSOH BIOSCINCEAIA360. Prolactin is measured using i-CHROMATM. Results: Hypothyroidism patients showed increased prolactin levels. Prolactin is increased in 40% of hypothyroidism patients.Also, TSH levels were significantly positively correlated with prolactin levels. Conclusion:The serum prolactin levels were increased in hypothyroidism infertile patients.