Assessment of Serum Level of Claudin‐3 and Its Association with Disease Severity in Patients with Psoriasis Vulgaris

Abstract

Background: Psoriasis is a common inflammatory disorder of the skin. Psoriasis is a disease of multifactorial origin where certain environmental factors acting on individuals with specific genetic predisposition leads to an immune dysregulation. Claudins are transmembrane proteins, which participate in the formation of tight junctions by binding to the actin cytoskeleton. Claudin-3 present in the blood is considered as a useful biomarker of intestinal permeability. Objective: To evaluate serum level of claudin-3 in patients with psoriasis in comparison to control group and correlate its levels with disease severity . Patients and methods: Fifty-three patients (32 males and 21 females) with psoriasis and forty normal healthy control (23 males and 17 females) who matched the cases group as regard age and sex were included in this work. They were randomly selected from the Dermatology Department outpatient clinic in Mansoura University Hospital. Results: Psoriasis group showed significantly higher level of claudin-3 when compared to control group (mean=58.3 versus 41.2; p<0.001). Smoking was significantly associated with higher Claudin-3 level (p=0.031). In addition, claudin-3 level increased gradually with increased severity grades (p<0.001). No significant associations were found regarding claudin-3 level according to gender, nutritional status, family history, in psoriasis group (p>0.05 for each). Higher BMI, smoking and higher claudin-3 level were associated with prediction of higher PASI score in univariate analysis. While multivariate analysis revealed that only smoking and higher claudin-3 level were considered independent predictor of more severe psoriasis cases. Conclusion: Claudin-3 level was significantly higher in patients with psoriasis than healthy controls. PASI correlated with claudin-3 levels.

Claudin‐3 is a novel intestinal integrity marker in patients with alopecia areata: Correlation with the disease severity

“…The unique and crucial finding of Sikora and his colleagues study was a significant, positive connection between claudin‐3 level and laboratory (neutrophil‐to‐lymphocyte ratio) and clinical (PASI) indicators of disease severity. In another recent study, PASI and claudin‐3 levels were correlated 14 …”

“…It has been demonstrated that claudin-3 expression along rat intestinal segments correlates with barrier properties. 14 The relationship between the immune system, intestinal barrier, and gut microbiome has drawn a lot of attention. A significant contributor to the pathogenesis of psoriasis and a potential treatment target has been identified as the so-called gut-skin axis.…”

“…It has been demonstrated that claudin‐3 is expressed more strongly in distal than in proximal portions inside tubular tissues such as the intestine and nephron. It has been demonstrated that claudin‐3 expression along rat intestinal segments correlates with barrier properties 14 . The relationship between the immune system, intestinal barrier, and gut microbiome has drawn a lot of attention.…”

“…In another recent study, PASI and claudin-3 levels were correlated. 14 In the current study, alopecia areata was predicted using multivariate logistic regression analysis. It revealed that claudin-3 was a significant predictor (OR = 1.217, 95% CI = 1.003-1.476, pvalue = 0.046) controlling for the effect of age, gender, and smoking.…”