Assessment of Serum IL-1, IL-2 and IFN-γ Levels in Untreated Pulmonary Tuberculosis Patients: Role in Pathogenesis

Katti, Muralidhar K.

doi:10.1016/j.arcmed.2011.04.012

Cited by 21 publications

(15 citation statements)

References 17 publications

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“…The IL-2 levels in the healthy controls are comparable to previously published levels in the same cohort [34]. However, the IL-2 levels in our study are different from the IL-2 levels observed in other studies [35]. Thus, PTB individuals appear to have both an intrinsic defect as well as an antigen-responsive defect in the optimal production of IL-2 in TB disease.…”

Section: Discussionsupporting

confidence: 69%

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment

et al. 2017

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BackgroundThe immune response to tuberculosis (TB) is T cell dependent. T cells are the major facilitators of protection and effector functions with CD4+ T cells being the most important players, followed by CD8+ T cells. The common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 play a vital role in peripheral T cell growth and survival. However, the role of common γ-chain cytokines in pulmonary TB (PTB) is poorly understood.Aim and methodsTo examine the association of circulating common γ-chain cytokines with TB disease or infection, we examined the systemic levels of IL-2, IL-7, IL-15, and IL-21 in individuals with PTB, latent TB (LTB) or no TB infection (NTB). We also examined the levels of these cytokines in PTB individuals before and after anti-tuberculosis treatment.ResultsCirculating levels of IL-2, IL-7 and IL-21 were significantly diminished in PTB compared to LTB or NTB individuals. Moreover, TB antigen stimulated whole blood also exhibited diminished levels of common γ-chain cytokines in PTB compared to LTB or NTB individuals. The plasma levels of common γ-chain cytokines exhibited no significant association with the severity or extent of TB disease or with bacterial burdens. However, upon standard anti-TB treatment, both the systemic as well as the TB antigen stimulated levels of IL-2, IL-7 and IL-21 were significantly increased in PTB individuals.ConclusionTherefore our data demonstrate that diminished levels of common γ-chain cytokines are a common characteristic of PTB and potentially highlight the importance of boosting these responses to improve treatment outcomes.

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Section: Discussionsupporting

confidence: 69%

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment

et al. 2017

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“…Administration of both drugs together induced the greatest benefit. Evidence indicates that IL-1 production is increased (rather than reduced) in most patients with tuberculosis [98][99][100] . Studies to identify subsets of patients with high levels of type I IFNs and a decreased ratio of PGE 2 /leukotriene A4 could help to evaluate the efficacy of this therapeutic approach.…”

Section: Other Pde Inhibitorsmentioning

confidence: 97%

Advancing host-directed therapy for tuberculosis

2015

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Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive host-directed therapies have the potential to shorten tuberculosis treatment duration, prevent resistance and reduce lung injury by promoting autophagy, antimicrobial peptide production and other macrophage effector mechanisms, as well as by modifying specific mechanisms that cause lung inflammation and matrix destruction. The range of candidates is broad, including several agents approved for other clinical indications that are ready for evaluation in Phase II clinical trials. The promise of new and existing host-directed therapies that could accelerate response and improve tuberculosis treatment outcomes is discussed in this Opinion article.

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“…It has been reported much that TB outcome and/or evolution partly depends on the manipulate host immunity by inducing a complex array cytokines [5], [6]. However, the immune responses from TB complicated with COPD patients were rarely studied.…”

Section: Introductionmentioning

confidence: 99%

Increased Cytokines Response in Patients with Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

et al. 2013

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ObjectivesTo explore the change and its significance of cytokines in patients with pulmonary tuberculosis complicated with COPD.MethodsThe immune function of 152 cases of pulmonary tuberculosis with COPD was detected to compare with 150 cases of patients with pulmonary tuberculosis, 157 cases of patients with COPD and 50 cases of healthy volunteers who were in the hospital during the same period. T lymphocyte cell population in peripheral blood was detected by flow cytometry. The serum levels of sIL-2R, IL-6, IFN-γ, TNF-α were measured using ELISA.ResultsThe percentage of CD4+ T cells in TB patients with or without COPD and COPD patients without TB was significantly lower than that in control group. The percentage of CD4+ T cells in patients with TB and COPD was significantly lower than that in the non-COPD TB patients. The percentage of CD8+ T cells was higher in the TB patients group than that in control group. The CD4+/CD8+ ratio in the TB patients group was significantly lower than that in control group. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in TB patients with or without COPD and COPD patients without TB were significantly higher than those in control group. In addition, sIL-2R, IL-6, TNF-α concentrations in the patients with TB and COPD were higher than those in the non-COPD TB patients. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in COPD patients with TB were significantly higher than those in COPD patients without TB. There was a significant negative correlation between serum levels of TNF-α, IL-6 and FEV1 (%, predicted) in COPD without TB group.ConclusionsThe patients with pulmonary tuberculosis complicated with COPD were impaired in cellular immunity, and its extent of immune impairment is more serious than those of the patients with pulmonary tuberculosis and the patients with COPD.

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Assessment of Serum IL-1, IL-2 and IFN-γ Levels in Untreated Pulmonary Tuberculosis Patients: Role in Pathogenesis

Cited by 21 publications

References 17 publications

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment

Advancing host-directed therapy for tuberculosis

Increased Cytokines Response in Patients with Tuberculosis Complicated with Chronic Obstructive Pulmonary Disease

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