Assessment of serum biotin levels and its association with blood glucose in gestational diabetes mellitus

Muthuraman, N; Vijayselvi, Reeta; P, Yesudas Sudhakar; Christudoss, Pamela; Abraham, Premila

doi:10.1016/j.eurox.2023.100181

Cited by 3 publications

(3 citation statements)

References 27 publications

(19 reference statements)

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“…Biotin intake during pregnancy was also associated with higher GDM odds. We only identified one study other than ours that assessed biotin in serum and GDM risk; however, the findings revealed no association [39]. More studies are needed in order to assess a clear relationship.…”

Section: Discussionmentioning

confidence: 76%

Impact of Maternal Micronutrient Intake on Gestational Diabetes Risk: Results from Greece’s BORN2020 Prospective Cohort Study

Tranidou,

Magriplis,

Apostolopoulou

et al. 2024

Nutrients

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Understanding how maternal micronutrient intake and dietary habits impact gestational diabetes mellitus (GDM) is crucial. Data from 797 pregnant women were prospectively analyzed to assess GDM status with the oral glucose tolerance test (OGTT). Nutritional intake was evaluated using a validated food frequency questionnaire (FFQ) across two periods: Period A, covering 6 months before pregnancy, and Period B, from pregnancy onset to mid-gestation (24 weeks). Micronutrient intakes were compared against the European Food Safety Authority (EFSA) dietary reference values (DRVs) and were used to estimate the mean adequacy ratio (MAR) to assess dietary adequacy. GDM was diagnosed in 14.7% (n = 117) of women with the characteristics of a higher mean maternal age (MA) and pre-pregnancy body mass index (BMI). Out of the 13 vitamins assessed, biotin, folate, niacin, and pantothenic acid were found significantly higher in the GDM group, as did iron, magnesium, manganese, phosphorus, and zinc from the 10 minerals. The results were influenced by the timing of the assessment. Importantly, MAR was higher during pregnancy and was found to increase the risk of GDM by 1% (95%CI: 1, 1.02). A sensitivity analysis revealed that reducing MAR significantly raised the GDM risk by 68% (95%CI: 1.02, 2.79). No association was revealed between adherence to the Mediterranean diet (MD) and GDM risk. These findings highlight areas for further investigation into whether dietary modifications involving these specific micronutrients could effectively influence GDM outcomes.

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Section: Discussionmentioning

confidence: 76%

Impact of Maternal Micronutrient Intake on Gestational Diabetes Risk: Results from Greece’s BORN2020 Prospective Cohort Study

Tranidou,

Magriplis,

Apostolopoulou

et al. 2024

Nutrients

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“…An ELISA-type assay was also developed by our group [ 130 ]. ELISA kits for biotin are currently commercially available and have been widely used for many years [ 76 , 126 , 131 , 132 ]. In a recent paper, biotin (among other analytes) was measured in blood plasma of healthy volunteers living in a low-altitude area who had been transported to high altitude using ultrahigh-performance liquid chromatography—tandem mass spectrometry (UHPLC-MS/MS) [ 133 ].…”

Section: Biotin Levels And/or Biotin Supplementation Proposed For Spe...mentioning

confidence: 99%

“…Moreover, a recently published study investigated whether there is a difference in biotin levels between pregnant women with and without gestational diabetes mellitus (GDM). As revealed, biotin levels were slightly decreased in pregnant women with GDM as compared with control pregnant women, though the difference was not statistically significant [ 132 ].…”

Section: Biotin Levels And/or Biotin Supplementation Proposed For Spe...mentioning

confidence: 99%

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Karachaliou,

Livaniou

2024

IJMS

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Biotin (vitamin B7, or vitamin H) is a water-soluble B-vitamin that functions as a cofactor for carboxylases, i.e., enzymes involved in the cellular metabolism of fatty acids and amino acids and in gluconeogenesis; moreover, as reported, biotin may be involved in gene regulation. Biotin is not synthesized by human cells, but it is found in food and is also produced by intestinal bacteria. Biotin status/homeostasis in human individuals depends on several factors, including efficiency/deficiency of the enzymes involved in biotin recycling within the human organism (biotinidase, holocarboxylase synthetase), and/or effectiveness of intestinal uptake, which is mainly accomplished through the sodium-dependent multivitamin transporter. In the last years, administration of biotin at high/“pharmacological” doses has been proposed to treat specific defects/deficiencies and human disorders, exhibiting mainly neurological and/or dermatological symptoms and including biotinidase deficiency, holocarboxylase synthetase deficiency, and biotin–thiamine-responsive basal ganglia disease. On the other hand, according to warnings of the Food and Drug Administration, USA, high biotin levels can affect clinical biotin-(strept)avidin assays and thus lead to false results during quantification of critical biomarkers. In this review article, recent findings/advancements that may offer new insight in the abovementioned research fields concerning biotin will be presented and briefly discussed.

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Assessment of IL-6, MDA, GSH and Serum Electrolytes in Diabetic Patients

Al-Kufaishi,

Al-Shukry,

Al-Musawi

2023

Biomed. Pharmacol. J.

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Background: The public health community has been paying a lot of attention to metabolic syndrome, sometimes known as diabetes mellitus (DM). In many cases for the patients with type 2 diabetes mellitus characterized by an uncontrolled rise in blood sugar (hyperglycemia) brought on by an inability of the body's cells (such as muscles) to detect and utilize the circulating insulin, a condition known as insulin sensitivity or insulin resistance, or by an insulin deficiency. (caused by pancreatic beta cell damage or decreased insulin release). These cases are accompanied by systematic inflammation in the long term, and as a result of the immune effect, there will be an increase in the levels of lipids peroxidation and thus a decrease in the levels of antioxidants. Objective: The study includes an evaluation of inflammatory levels and oxidative stress through an assay of IL-6, malondialdehyde, glutathione, and serum electrolyte levels in the patients with uncontrolled type 2 diabetes mellitus compared with the control. Methods: The case-control study, where ablood sample collections from patients with uncontrolled type 2 diabetes mellitus and control apparently healthy. The samples were analyzed by ELISA, spectrophotometers, and electro-analyzer apparatus. Results: It was found that patients with uncontrolled type 2 diabetes have lower-grade inflammation, which is the reason for the significant increase in interleukin-6 (215±13 Pg/mL) compared with healthy (50±10 Pg/mL). Also, the high levels of free radicals and peroxides can be expressed by the increase in malondialdehyde, as well as a significant reduction in the levels of glutathione value. Patients with uncontrolled type 2 diabetes suffer from electrolyte disturbances due to excessive urine caused by high osmolality and metabolic acidosis due to high ketone bodies and consequently high potassium levels (hyperkalemia) (6.7±0.59 mmol/L). Conclusion: Uncontrolled high diabetes in type 2 patients leads to high inflammatory levels in the body, and this is the reason for increase interleukin 6 levels. Inflammations caused by the immune effect resulting from diabetes lead to the synthesis of higher levels of free radicals, leading to the oxidation of lipids and a decrease of glutathione concentration.

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Assessment of serum biotin levels and its association with blood glucose in gestational diabetes mellitus

Cited by 3 publications

References 27 publications

Impact of Maternal Micronutrient Intake on Gestational Diabetes Risk: Results from Greece’s BORN2020 Prospective Cohort Study

Impact of Maternal Micronutrient Intake on Gestational Diabetes Risk: Results from Greece’s BORN2020 Prospective Cohort Study

Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives

Assessment of IL-6, MDA, GSH and Serum Electrolytes in Diabetic Patients

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