Assessment of serum biochemical parameters and pathological changes in broilers with chronic aflatoxicosis fed glucomannan-containing yeast product (Mycosorb) and sodium bentonite

Abstract

The purpose of this study was to evaluate the efficacy of yeast glucomannan (YG) and sodium bentonite (SB) in reducing the toxicity in broilers fed a diet naturally contaminated with aflatoxin. Three hundred 7-day-old Ross 308 strain broilers were chosen and randomly assigned to 10 dietary treatments. Serum biochemical parameters and pathological changes in the liver were investigated at 42 d of age. Chickens fed a diet containing 250 ppb of aflatoxin displayed a decrease in uric acid, cholesterol, and triglycerides, and an increase in serum activities of AST and ALT when compared to control group. There were considerable gross and histopathological hepatic lesions (P < 0.05) in the form of small to moderate hydropic and/or fatty degeneration, bile duct hyperplasia, periportal fibrosis, cells infiltration, and congestion, in chickens fed the 250 ppb aflatoxincontaining diet. The addition of YG and SB to the aflatoxin-containing diet partially reduced the negative effects of aflatoxin. The 0.1% YG supplementation to the aflatoxin-contaminated diet significantly prevented the pathological effect of aflatoxin on serum biochemical parameters and liver, and was found to be more effective than other treatments.

The Assessment of Diet Contaminated with Aflatoxin B1 in Juvenile Turbot (Scophthalmus maximus) and the Evaluation of the Efficacy of Mitigation of a Yeast Cell Wall Extract

“…Therefore, dietary YCWE could decrease the health risk resulting from feed consumption with AFB 1 contamination. The results agree with previous studies in cows (10 g YCWE/cow per day) [58] and broilers (0.1% or 0.25% addition) [61,62,102,103]. Further, Diet 8 resulted in significantly higher alpha diversity and abundance of some potential beneficial bacteria compared to Diet 6; the abundance of potential pathogenic bacteria Salmonella, Aeromonas and Comamonas was lowered by Diet 8 compared to Diet 1.…”

Effectsofaflatoxinb1only or Co-Administered With Mycotox Ng on Liver Function in Turkey Broilers

“…Aflatoxins are of particular importance for the poultry industry due to their high toxicity and frequent contamination of feeds. Feeds contaminated with aflatoxins reduce the activity of numerous enzymes involved in the metabolism of carbohydrates, proteins, fats and nucleic acids (Azizpour and Moghadam, 2015). Chronic and subchronic aflatoxicosis could be detected through analysis of changes in blood serum biochemical and haematological parameters before any clinical signs become visible.…”

“…Compared to control group of birds, the addition of 0.5 g/kg Mycotox NG to the feed of Groups V and VIreducedpartlythedeleteriouseffectsofaflatoxinВ 1 on blood concentrations of studied biochemical blood parameters and the extent of histological liver changes. It is presumed that most of aflatoxin molecules are absorbed by feed ingredients in the gastrointestinal tract causing less adverse effects on the histostructure of target organs and blood biochemical parameters (Azizpour and Moghadam, 2015). These data are in concordance with those reported by other authors having used brewers' yeasts (Saccharomyces cerevisiae) (Che et al, 2011; Valchev et al, 2014) and bentonite (montmorillonite) (Shi et al, 2009;Valchev et al, 2014) .The process of binding of aflatoxins with toxinbinders is based on the principle of electric polarity.…”

Protective Effects of Rhino-Hepato Forte in Broiler Chickens During Aflatoxicosis

“…Much work has been done on Aflatoxin B1 (AFB1), the most potent of these mycotoxins, exploring hepatotoxic, carcinogenic, mutagenic, teratogenic and immunosuppressive effects in many animal species including poultry [8]. The Toxic effects of Aflatoxin on poultry hematological and blood biochemistry [9], Immunological [10], gross and histopathology. were well documented [11].…”