Assessment of sequential combination of 5-fluorouracil-loaded-chitosan-nanoparticles and ALA-photodynamic therapy on HeLa cell line

Benito-Miguel, Marta; Blanco, Ma Dolores; Gómez, Clara

doi:10.1016/j.pdpdt.2015.05.001

Cited by 18 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hep G2 cell line. Benito-Miguel et al [11] also reported the similar result against HeLa cells. A similar result was also observed by Nivethaa et al [12] who reported excellent anticancer activity of 5FU encapsulated Chitosan/silver/multiwalled carbon nanotube against MCF-7 cell line and found an IC50 value of 50µg/ml.…”

Section: Resultsmentioning

confidence: 56%

In Vitro Anticancer Activity of 5’ Fluo Uracil Coated Chitosan Nanoparticle

Shaima

Moorthi

Kutty

2016

Int J Curr Pharm Sci

View full text Add to dashboard Cite

Objective: 5' Fluorouracil (5'FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line. Methods:The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM). Results: The 5FCN revealed an IC50Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model. value of 49.50 µl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment.

show abstract

Section: Resultsmentioning

confidence: 56%

In Vitro Anticancer Activity of 5’ Fluo Uracil Coated Chitosan Nanoparticle

Shaima

Moorthi

Kutty

2016

Int J Curr Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Cells that are poorly differentiated and rapidly proliferating, as is common in many tumors, may produce insufficient amounts of PpIX . One area of investigation to address this issue involves the use of cellular differentiators such as vitamin D or its analogues, methotrexate, retinoic acid, 5‐fluorouracil acid, iron chelators and the androgens 5α‐dihydrotestosterone (DHT) and R1881 .…”

Section: Targeting the Tumor Microenvironment With Photochemistrymentioning

confidence: 99%

“…Actinic keratoses, melanoma, cervical cancer, mucosal lesions, intraepithelial squamous cell carcinoma (193)(194)(195)(196)(197) (215)(216)(217) dilated (53). This vascular network often exhibits large pores, enabling increased extravasation of nanoparticle drug carriers into the tumor site for heightened drug accumulation.…”

Section: -Fluorouracil Increases Coproporphyrinogenmentioning

confidence: 99%

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

Sorrin

Ruhi

Ferlic

et al. 2020

Photochem & Photobiology

View full text Add to dashboard Cite

Targeting the tumor microenvironment (TME) provides opportunities to modulate tumor physiology, enhance the delivery of therapeutic agents, impact immune response and overcome resistance. Photodynamic therapy (PDT) is a photochemistry‐based, nonthermal modality that produces reactive molecular species at the site of light activation and is in the clinic for nononcologic and oncologic applications. The unique mechanisms and exquisite spatiotemporal control inherent to PDT enable selective modulation or destruction of the TME and cancer cells. Mechanical stress plays an important role in tumor growth and survival, with increasing implications for therapy design and drug delivery, but remains understudied in the context of PDT and PDT‐based combinations. This review describes pharmacoengineering and bioengineering approaches in PDT to target cellular and noncellular components of the TME, as well as molecular targets on tumor and tumor‐associated cells. Particular emphasis is placed on the role of mechanical stress in the context of targeted PDT regimens, and combinations, for primary and metastatic tumors.

show abstract

“…To date, several studies have reported the use of 5-FU and ALA together in different cancers; these include cervical and colorectal tumors [ 29 , 30 ]. Furthermore, auxiliary medications that might be incorporated into treatment procedures to prevent cancer patients from the gastrointestinal mucositis adverse effects induced by 5-FU would be advantageous.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats

et al. 2022

View full text Add to dashboard Cite

Alpha-lipoic acid (ALA) is extensively utilized in multivitamin formulas and anti-aging products. The purpose of this study was to investigate the potential protective benefits of ALA on 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in Wistar albino rats. Tissues from the stomach, small intestine, and large intestine were excised, and blood sera were obtained to identify biochemical indices such as TNF-α, IL-1β, MDA, GPx, SOD, MMP-1, -2, -8, and TIMP-1. A histopathological study was also performed. The results revealed mucositis-elevated TNF-, IL-1, MDA, MMP-1, -2, -8, and TIMP-1 levels in both tissues and sera, and these values dropped dramatically following ALA treatment. Reduced SOD and GPx activities in mucositis groups were reversed in ALA-treated groups. The damage produced by mucositis in the stomach and small intestine regressed in the ALA-treated group, according to histopathological evaluation. Consequently, the implementation of ALA supplementation in 5-FU therapy may act as a protective intervention for cancer patients with gastrointestinal mucositis. In light of the findings, ALA, a food-derived antioxidant with pleiotropic properties, may be an effective treatment for 5-FU-induced gastrointestinal mucositus, and prevent oxidative stress, inflammation, and tissue damage in cancer patients receiving 5-FU therapy.

show abstract

Assessment of sequential combination of 5-fluorouracil-loaded-chitosan-nanoparticles and ALA-photodynamic therapy on HeLa cell line

Cited by 18 publications

References 32 publications

In Vitro Anticancer Activity of 5’ Fluo Uracil Coated Chitosan Nanoparticle

In Vitro Anticancer Activity of 5’ Fluo Uracil Coated Chitosan Nanoparticle

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats

Contact Info

Product

Resources

About