Assessment of Sensorimotor and Cognitive Deficits Induced by a Moderate Traumatic Injury in the Right Parietal Cortex of the Rat

Piot-Grosjean, Odile; Wahl, Florence; Gobbo, Oliviero L.; Stutzmann, Jean‐Marie

doi:10.1006/nbdi.2001.0450

Cited by 57 publications

(40 citation statements)

References 54 publications

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“…Earlier studies have shown an approximately two-to fourfold increase in traverse time, depending on the severity of the injury, for adult injured animals compared to sham animals at post-injury days 1 and 2 (Statler et al, 2006, Piot-Grosjean et al, 2001. The lack of detectable deficits in beam traverse times among PND75 CCI animals in the present study may be explained by the comparatively milder injury and=or the difference in beam width used.…”

Section: The Effects Of the Ketogenic Diet On Motor Recoverysupporting

confidence: 42%

The Effects of a Ketogenic Diet on Behavioral Outcome after Controlled Cortical Impact Injury in the Juvenile and Adult Rat

Appelberg

Hovda

Prins

2009

Journal of Neurotrauma

118

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The ketogenic diet has been shown to have unique properties that make it a more suitable cerebral fuel under various neuropathological conditions (e.g., starvation, ischemia, and traumatic brain injury (TBI). Recently, agedependent ketogenic neuroprotection was shown among postnatal day 35 (PND35) and PND45 rats after TBI, but not in PND17 and PND65 animals (Prins et al., 2005). The present study addresses the therapeutic potential of a ketogenic diet on motor and cognitive deficits after TBI. PND35 and PND75 rats received sham or controlled cortical impact (CCI) surgery and were placed on either standard (Std) or ketogenic (KG) diet for 7 days. Beam walking and the Morris water maze (MWM) were used to assess sensory motor function and cognition, respectively. PND35 CCI Std animals showed significantly longer traverse times than sham and CCI KG animals at the beginning of motor training. Footslip analysis revealed better performance among the sham and the CCI KG animals compared to the CCI Std group. In the MWM PND35 CCI KG animals showed significantly shorter escape latencies compared to CCI Std-fed animals. During the same time period there was no significant difference between sham animals and CCI KG animals. The therapeutic effect of the ketogenic diet on beam walking and cognitive performance was not observed in PND75 animals. This finding supports our theory about agedependent utilization and effectiveness of ketones as an alternative fuel after TBI.

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Section: The Effects Of the Ketogenic Diet On Motor Recoverysupporting

confidence: 42%

The Effects of a Ketogenic Diet on Behavioral Outcome after Controlled Cortical Impact Injury in the Juvenile and Adult Rat

Appelberg

Hovda

Prins

2009

Journal of Neurotrauma

118

View full text Add to dashboard Cite

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“…While these neurological deficits disappeared on the 7 th day after surgery, rotarod performance of MS rats was significantly impaired after surgery in comparison Table 1 with sham rats. Rotarod performance is considered to reflect equilibrium function and the ability to perform coordinated movement [19]. Miyake et al [14] reported that striatal blood flow on the microsphere-injected side was decreased on the 3 rd day after surgery, and this was maintained up to the 14 th day after surgery.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Lactate Threshold During Treadmill Exercise After Microsphere-Induced Infarction in Rats

Takahashi¹,

Himi²,

Kuniyasu³

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

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Objectives The aim of this study was to clarify changes in the lactate threshold (LT) in the acute period after cerebral infarction.Methods Cerebral infarction was induced by the injection of microspheres (MS) into the right internal carotid artery. To estimate the degree of neurological deficit caused by surgery, the behaviors of all rats were evaluated in terms of typical symptoms of stroke in rats. A rotarod test was used to evaluate equilibrium function. Rats were forced to perform stepwise treadmill exercises and serial changes in the blood lactate concentration were measured for determination of the LT. ResultsThe average treadmill speed at the LT and rotarod performance in MS rats was significantly lower than those in sham-operated rats on the 2 nd days after surgery.However, while neurological deficits disappeared on the 7 th days after surgery in MS rats, the LT and rotarod performance were significantly lower than those in shamoperated rats. ConclusionThese results suggest that the decrease in the LT in the acute period following cerebral infarction may be induced by impairment of the equilibrium function.Other possibilities are also discussed.

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“…In animal models, long lasting cognitive deficits are observed not only after severe brain injury [10] but also after moderate [33] and even mild concussions which do not involve appreciable neuronal cell loss [48]. More recent studies in animals are beginning to report significant inflammation and neurodegeration linked to minor surgery such as electrode implanatation [34], although to our knowledge the cognitive effects of a microdialysis probe cannulation have not been documented.…”

Section: Introductionmentioning

confidence: 99%

Metabolic and behavioral deficits following a routine surgical procedure in rats

et al. 2007

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To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was assessed using the novel object recognition (NOR) test, administered 3 days prior to and 3, 7, 14, and 56 days after surgery. At each time point, general locomotion was also measured. Metabolic imaging with 18 F-fluorodeoxyglucose ([ 18 F]FDG) occurred 28 and 58 days after surgery. Animals with surgical implants performed significantly worse on tests of object recognition, while general locomotion was unaffected by the implant. There was a significant decrease in glucose uptake after surgery in most of the hemisphere ipsilateral to the implant relative to the contralateral hemisphere. At both time points, the most significant metabolic deficits occurred in the primary motor cortex (-25%; p<0.001), sensory cortex (-15%, p<0.001) and frontal cortex (-12%; p<0.001). Ipsilateral areas further from the site of insertion became progressively worse, including the sensory cortex, dorsal striatum and thalamus. This data was supported by a voxel-based analysis of the PET data, which revealed again a unilateral decrease in [ 18 F]FDG uptake that extended throughout the ipsilateral cortex and persisted for the duration of the 58-day study. Probe implantation in the striatum results in a widespread and long lasting decline in cortical glucose metabolism together with a persistent, injury-related deficit in the performance of a cognitive (object recognition) task in rats.

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Assessment of Sensorimotor and Cognitive Deficits Induced by a Moderate Traumatic Injury in the Right Parietal Cortex of the Rat

Cited by 57 publications

References 54 publications

The Effects of a Ketogenic Diet on Behavioral Outcome after Controlled Cortical Impact Injury in the Juvenile and Adult Rat

The Effects of a Ketogenic Diet on Behavioral Outcome after Controlled Cortical Impact Injury in the Juvenile and Adult Rat

Changes in the Lactate Threshold During Treadmill Exercise After Microsphere-Induced Infarction in Rats

Metabolic and behavioral deficits following a routine surgical procedure in rats

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