Assessment of seminal YKL‐40 in infertile men with varicocele

Rahman, S.; Rashed, Laila Ahmed; Akl, E.M.; Mostafa, Taymour

doi:10.1111/and.13756

Cited by 3 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, increased seminal Cys C in infertile OAT men with varicocele could be explained on the background of increased seminal features of apoptosis, oxidative stress as well autophagy in varicocele‐associated cases (Abd El Rahman et al., 2020; Dieamant et al., 2017; Foroozan‐Broojeni et al., 2019; Ghandehari‐Alavijeh et al., 2019; Mikhael et al., 2018; Zalata et al., 2011). Besides, the current study showed significant decreases in the seminal levels of Cys C after varicocelectomy concomitant with the improved semen parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Lately, in their systemic review, Asafu-Adjei et al (2020) demonstrated significant improvement in the mean sperm concentration after varicocelectomy in men with all varicocele grades where the magnitude of improvement was directly related to varicocele grade. As well, several studies linked increased varicocele grade with seminal apoptotic and oxidative stress harmful effects(Ashrafzade et al, 2020;Mostafa et al, 2020;Vivas-Acevedo et al, 2010).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of seminal cystatin C levels in infertile men with varicocele: A preliminary study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Varicocele has been raised as a contributor to male infertility supported by the improvement of sperm parameters after varicocelectomy. Cystatin C (Cys C) has been linked to several cellular changes that are common in male infertility cases associated with varicocele such as apoptosis and autophagy. This preliminary study aimed to assess the seminal levels of Cys C in infertile oligoasthenoteratozoospermic (OAT) men associated with varicocele that have been shown to have spermatic vein vasodilation and active death pathway. Overall, 60 men were investigated being divided into two equivalent groups—infertile OAT men with varicocele who underwent varicocelectomy and healthy fertile men as a control group. These men were subjected to history taking, clinical examination, semen analysis and assessment of seminal Cys C pre and 6 months post‐varicocelectomy. The results showed a significant increase of seminal Cys C in infertile OAT men with varicocele than the fertile control (55.57 ± 25.6 ng/ml versus 10.78 ± 1.88 ng/ml, p = .001). Seminal Cys C was a significantly decreased post‐operative than its pre‐operative level (34.69 ± 14.02 versus 55.57 ± 25.6 ng/ml, p = .01). These results show a potential role of Cys C in varicocele‐induced infertility.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Assessment of seminal cystatin C levels in infertile men with varicocele: A preliminary study

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been reported that varicocoelectomy induces decreased seminal YKL‐40 levels and improves semen parameters. There is a negative correlation of seminal YKL‐40 levels with sperm count, total motility and normal morphology indicating YKL40 could be a useful biomarker for the varicocoele 191 …”

Section: Effect Of Varicocoele On Seminal Plasma Milieumentioning

confidence: 99%

“…There is a negative correlation of seminal YKL-40 levels with sperm count, total motility and normal morphology indicating YKL40 could be a useful biomarker for the varicocoele. 191 miRNAs are powerful regulators of key cellular processes such as differentiation, proliferation, and apoptosis by affecting protein translation. Seminal plasma micro-RNAs (Let-7 and miR-19b) may be potential biomarkers for spermatogenic status as they are released from germinal cells and their expression is largely stable.…”

Section: Effect Of Varicocoele On Seminal Plasma Milieumentioning

confidence: 99%

Varicocoele‐associated male infertility: Cellular and molecular perspectives of pathophysiology

2022

View full text Add to dashboard Cite

Background Varicocoele is a common risk factor associated with reduced male fertility potential. The current understanding of varicocoele pathophysiology does not completely explain the clinical manifestation of infertility. The present treatment options such as antioxidant supplementation and varicocoelectomy only help ≈35% of men to achieve spontaneous pregnancy. Objective This review aims to summarize the available knowledge on cellular and molecular alterations implicated to varicocoele‐associated male infertility and also highlights the new knowledge generated by “omics” technologies. Materials and Methods PubMed, MEDLINE, Cochrane and Google Scholar databases are searched using different combinations of keywords (varicocoele, infertile/fertile men with varicocoele, cellular changes, molecular mechanisms, proteome, epigenome, transcriptome and metabolome). A total of 229 relevant human and animal studies published till 2021 were included in this review. Results Current understanding advocates oxidative stress (OS) as a major contributory factor to varicocoele‐associated male infertility. Excessive OS causes alteration in testicular microenvironment and sperm DNA fragmentation, which further contributes to infertility. Molecular and omics studies have identified several promising biomarkers such as AAMP, SPINT1, MKI67 (genetic markers), sperm quality and function related protein markers, global sperm DNA methylation level (epigenetic marker), Hspa2, Protamine, Gadd7, Dynlt1 and Beclin1 (mRNA markers), PRDX2, HSPA, APOA2, YKL40 (seminal protein markers), total choline and PHGDH (metabolic markers). Discussion Mature spermatozoa harbours a plethora of molecular information in form of proteome, epigenome and transcriptome, which could provide very important clues regarding pathophysiology of varicocoele‐associated infertility. Recent molecular and omics studies in infertile men with varicocoele have identified several promising biomarkers. Upon further validation with larger and well‐defined studies, some of these biomarkers could aid in varicocoele management. Conclusion The present evidences suggest that inclusion of OS and sperm DNA fragmentation tests could be useful to the diagnostic workup for men with varicocoele. Furthermore, including precise molecular markers may assist in diagnostics and prognostics of varicocoele‐associated male infertility.

show abstract

Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Cannarella

Shah

Hamoda

et al. 2024

World J Mens Health

Self Cite

View full text Add to dashboard Cite

Purpose The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129–0.278; p<0.001; I 2 =83.62%, Egger’s p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474–1.706; p<0.001; I 2 =97.86%, Egger’s p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526–2.121; p<0.001; I 2 =97.88%, Egger’s p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318–1.968; p<0.001; I 2 =98.65%, Egger’s p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%–2.153%; p<0.001; I 2 =98.97%, Egger’s p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%–1.759%; p<0.001; l2=97.98%, Egger’s p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%–1.211%; p<0.001; I 2 =97.87%, Egger’s p=0.1864. Conclusions The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.

show abstract

Assessment of seminal YKL‐40 in infertile men with varicocele

Cited by 3 publications

References 39 publications

Assessment of seminal cystatin C levels in infertile men with varicocele: A preliminary study

Assessment of seminal cystatin C levels in infertile men with varicocele: A preliminary study

Varicocoele‐associated male infertility: Cellular and molecular perspectives of pathophysiology

Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Contact Info

Product

Resources

About