Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40

Herman, Waldemar A; Seńko, Aleksandra; Korczowska, Izabela; Łącka, Katarzyna

doi:10.20452/pamw.817

Cited by 5 publications

(4 citation statements)

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“…In controls, seral serpin A3 was in the range of 0.05e0.23 mg/ml, the level in the two frameshift variant carriers at the range's low end (Figure 1b), matching the finding of a haploinsufficient gene. In male controls, we observed evidence for some correlation of serpin A3 with age ( Figure 1c), confirming previous results (Herman et al, 2009). More importantly, the finding underlines the relevance of very low levels of serpin A3 in our 75-year-old male patient with GPP.…”

Section: Orcidssupporting

confidence: 91%

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Frey

Sticht

Wilsmann‐Theis

et al. 2020

Journal of Investigative Dermatology

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Section: Orcidssupporting

confidence: 91%

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Frey

Sticht

Wilsmann‐Theis

et al. 2020

Journal of Investigative Dermatology

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“…The reasons behind this imbalance in DHEAs levels are not entirely known. The elevated concentration of circulating cytokines and immune-endocrine mediators could also play a role, as several studies have observed an inverse association between immunological markers, such as C reactive protein, and DHEA levels [38,39]. It has been hypothesized that certain immunological products can have a direct action at the adrenal glands, inhibiting the steroidogenesis of molecules such as DHEA [40,41].…”

Section: Discussionmentioning

confidence: 99%

Circulating DHEA-S levels and major cardiovascular outcomes in chronic Chagas cardiomyopathy: A prospective cohort study

Rojas

Gómez‐Ochoa

Echeverría

et al. 2022

International Journal of Cardiology

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To analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM) diagnosis. Background: DHEA-S is among the main endogenous steroid hormones. Some studies have suggested a relevant role of this hormone in infections and the setting of CCM. Nevertheless, no study has evaluated the prognostic role of DHEA-S in CCM patients. Methods: Prospective cohort study. Patients with CCM and reduced ejection fraction were included. We explored the association of DHEA-S levels with NT-proBNP levels and echocardiographic variables using linear regression models. Next, by using Cox Proportional Hazard models, we examined whether levels of DHEA-S could predict a composite outcome (CO) including all-cause mortality, cardiac transplantation, and implantation of a left ventricular assist device (LVAD). Results: Seventy-four patients were included (59% males, median age: 64 years). After adjustment for confounding factors, high DHEA-S levels were associated with better LVEF, lower left atrium volume, end-systolic volume of the left ventricle and lower NT-proBNP levels. 43% of patients experienced the CO during a median follow-up of 40 months. Increased levels of DHEA-S were associated with a lower risk of developing the CO (HR 0.43; 95%CI 0.21-0.86). Finally, adding DHEA-S to the multivariate model did not improve the prediction of the CO, but substituting NT-proBNP in the model with DHEA-S showed similar performance. Conclusions: In patients with CCM, higher DHEA-S levels were associated with lower mortality, heart transplantation, and LVAD implantation. Further larger studies are required to confirm our results and assess causality.

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“…In addition, fibrinogen levels are significantly correlated with the amount of bacteria found in blood (Amar et al, 2011). CRP, LDL, and fibrinogen increase during aging (Abbott et al, 1983; Kannel et al, 1987; Herman et al, 2009), findings that support a link between microbial burden with the progression of CVD.…”

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confidence: 96%

Classifying Aging As a Disease: The Role of Microbes

Lustgarten

2016

Front. Genet.

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Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40

Cited by 5 publications

References 0 publications

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Circulating DHEA-S levels and major cardiovascular outcomes in chronic Chagas cardiomyopathy: A prospective cohort study

Classifying Aging As a Disease: The Role of Microbes

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