This study was initiated to optimize chemical control against Phytophthora katsurae on coconut trees with different concentrations of the fungicide phosphorous acid. In vivo, different concentrations of phosphorous acid [2.8 g (TA), 5.6 g (TB), and 11.2 g (TC) of active ingredient (a.i.)] dissolved in water, were injected into the stipes of the coconut varieties Equatorial Green Dwarf (EGD) and the hybrid PB 121 + cultivars in comparison with the same untreated cultivars. Soft and brutal inoculation, a strain of Phytophthora katsurae from naturally infected nuts was used to follow its behavior on the nuts of these cultivars treated with phosphorous acid or not. As a result, external and internal symptoms on nuts evolved according to the concentrations of acid received. 11.2 g (TC) of a.i of phosphorous acid provided protection beyond 12 months with good inhibition of pathogen growth, as opposed to 2.8 g (TA) and 5.6 g (TB) of a.i. fluctuated between 3 and 9 months depending on the varieties. This study showed a persistence of phosphorous acid in coconut tissues at high concentration in the control of Phytophthora katsurae.