Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension

Alpsoy, Şeref; Doğan, B.N.; Gür, Demet Özkaramanlı; Akyüz, Aydın; Fidan, Çiğdem; Güzel, Savaş; Ozkoyuncu, Berna

doi:10.1080/10641963.2020.1797086

Cited by 7 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The available literature has provided information about salusin β in children with hypertension, obesity, lipid disorders, and Down syndrome [ 36 , 37 , 38 , 39 ]. The publications concerning adult patients are more numerous and concentrate on symptomatic atherosclerosis or conditions directly leading to atherosclerosis, such as diabetes, hypertension, dyslipidemia, and obesity [ 40 , 41 , 42 , 43 ]. The type of oncological treatment also seems to be a factor of higher risk of atherosclerosis, but this was not reflected in the levels of salusin β.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

et al. 2023

View full text Add to dashboard Cite

Background: The survivors of childhood cancer suffer from a number of long-term side effects. These include atherosclerosis and cardiovascular diseases (CVDs) that develop earlier in adulthood than in the rest of the population. The aim of this study was to identify prognostic factors of developing atherosclerosis before the development of symptomatic CVD. Methods: A total of 141 children that were 7–18 years old were examined; there were 116 survivors of childhood malignancies (hematopoietic and lymphoproliferative malignancies—52; neuroblastoma—22; Wilms tumor—24; other solid tumors—18) and 25 healthy controls. Anthropometric measurements, blood pressure measurements, ultrasonography of the abdomen, echocardiography, and laboratory tests were performed. Results: There were no significant differences in gender distribution, time from the end of the treatment, weight, BMI, prevalence of central obesity, blood pressure and resistive index of the renal arteries, lipid profile, or glucose and fibrinogen levels. Patients with solid tumors had a significantly lower height and worse renal function. Patients with hematological malignancies significantly presented the lowest shortening fraction of the left ventricle. The salusin β levels were significantly higher in the control group than among the patients. Conclusions: The type and severity of side effects are closely related to the type of neoplasm and the treatment that has been undergone. Careful observation and regular follow-up are necessary.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Additionally, non-dipper hypertension patients had lower salusin-α and higher salusin-β levels compared to those with dipper hypertension. In the same study, both salusins were also associated with a left ventricular mass [ 40 ]. In patients with coronary atherosclerosis, salusin-α and, to a greater extent, salusin-β were associated with the degree of coronary stenosis [ 41 , 42 ].…”

Section: Salusin-α and -βmentioning

confidence: 99%

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

Močnik

Varda

2022

Children

View full text Add to dashboard Cite

Cardiovascular diseases are the leading cause of morbidity and mortality in the modern world. Their common denominator is atherosclerosis, a process beginning in childhood. In pediatrics, the aim of preventive measures is to recognize children and adolescents at risk for accelerated atherosclerosis and possible premature cardiovascular events in adulthood. Several diagnostic procedures and biomarkers are available for cardiovascular risk assessment in adults. However, reliable markers in pediatrics are still insufficiently studied. In this contribution, we discuss five potential biomarkers of particular interest: kidney injury molecule-1, salusin-α and -β, uromodulin, and adropin. Studies regarding the pediatric population are scarce, but they support the evidence from studies in the adult population. These markers might entail both a prognostic and a therapeutic interest.

show abstract

“…Salusin-α and -ß are involved directly in the process of atherosclerosis with salusin-α slowing down and salusin-ß promoting atherosclerosis. In children, salusin-α correlated negatively with diastolic pressure [50,51]. Adropin was discovered recently as a regulator of endothelial function among its several other physiological roles, such as angiogenesis, metabolism of glucose, fatty acids and dyslipidemia.…”

Section: Future Perspectivesmentioning

confidence: 99%

Cardiovascular Risk Factors in Children

Močnik¹,

Varda²

2022

Risk Factors for Cardiovascular Disease

View full text Add to dashboard Cite

Cardiovascular morbidity and mortality are still increasing in developed countries with emphasis on the obesity epidemic. Children and young adults are no exception. With modern lifestyle, traditional cardiovascular risk factors, such as hypertension, obesity, dyslipidemia, insulin resistance, kidney damage, are increasingly present in children leading to premature cardiovascular events in adult life. Cardiovascular risk factor can accelerate naturally progressing atherosclerosis, which should be prevented to facilitate quality and longevity of life. Primary and primordial prevention in the pediatric population are of utmost importance. However, if a cardiovascular risk factor is already present, frequent monitoring of possible development of other cardiovascular risk factors and evaluation of end organ damage should be implemented to intervene in time.

show abstract

Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension

Cited by 7 publications

References 27 publications

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

Cardiovascular Risk Factors in Children

Contact Info

Product

Resources

About