2013
DOI: 10.1007/s11307-013-0632-0
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Assessment of S Values in Stylized and Voxel-Based Rat Models for Positron-Emitting Radionuclides

Abstract: The produced S values for common positron-emitting radionuclides can be exploited in the assessment of radiation dose to rats from different radiotracers used in small animal PET experiments. This work contributes to a better understanding of the influence of different computational models on small animal dosimetry.

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Cited by 8 publications
(12 citation statements)
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“…23,24,[41][42][43]53 However, significant differences between the dosimetric characteristics of stylized and voxel-based models for the same subject are often reported. [44][45][46][47] In the case of the newborn, the variations of the estimated self-absorbed S-values for positron-emitting radionuclides may range from −78% to 132% between stylized and voxel-based phantoms in representative organs. Since some biological tissues in children may have substantially different physical characteristics and tissue chemical compositions and present with significantly different radiosensitivity and bioavailability for various radiotracers at different ages, the evaluation of age-dependent absorbed dose using realistic anatomical anthropomorphic pediatric phantoms is commended.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…23,24,[41][42][43]53 However, significant differences between the dosimetric characteristics of stylized and voxel-based models for the same subject are often reported. [44][45][46][47] In the case of the newborn, the variations of the estimated self-absorbed S-values for positron-emitting radionuclides may range from −78% to 132% between stylized and voxel-based phantoms in representative organs. Since some biological tissues in children may have substantially different physical characteristics and tissue chemical compositions and present with significantly different radiosensitivity and bioavailability for various radiotracers at different ages, the evaluation of age-dependent absorbed dose using realistic anatomical anthropomorphic pediatric phantoms is commended.…”
Section: Discussionmentioning
confidence: 99%
“…However, significant differences have been reported between dosimetric results of stylized and voxel-based models of the same subject. [44][45][46][47] Therefore, the assessment of radiation dose for commonly used positron-emitting radionuclides in new generation anthropomorphic pediatric phantoms is highly desired.…”
Section: Introductionmentioning
confidence: 99%
“…The effect of model type and maternal physical changes during gestation on resulting S values from various radionuclides to the pregnant population was studied. A large difference between S values was observed for hollow organs when using the MIRD-type mathematic models and the voxel-based models (29,30). The S values of voxel-based models used in this work would be more accurate than those of mathematic models because the former preserves more anatomic details of the human body.…”
Section: Discussionmentioning
confidence: 89%
“…The discrepancies between small animal dosimetric results when using stylized, voxel, and hybrid models were also studied and reported in numerous contributions. 5,109,110 Overall, the ratios of self-absorbed S-factors ranged between 0.6 and 1.0 when comparing hybrid and voxel-based models and between 0.2 and 1.6 when comparing stylized and voxelbased models. The input parameters used for the simulations, such as model resolution, organ segmentation, tissue density, and spatial sampling, proved to have a substantial influence on small animal absorbed dose calculations when using hybrid models.…”
Section: A Ionizing Radiation Dosimetrymentioning
confidence: 99%