Assessment of Rodent Glioma Models Using Magnetic Resonance Imaging Techniques

Towner, Rheal A.; He, Ting; Doblas, Sabrina; Smith, Nataliya

doi:10.5772/23707

Advances in the Biology, Imaging and Therapies for Glioblastoma 2011

DOI: 10.5772/23707

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Assessment of Rodent Glioma Models Using Magnetic Resonance Imaging Techniques

Rheal A. Towner¹,

Ting He²,

Sabrina Doblas³

et al.

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2013

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Cited by 1 publication

References 73 publications

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Recent Approaches and Novel Therapeutic Targets in Human Glioma

Vishwakarma¹,

Paspala²,

Bardia³

et al. 2013

ACRT

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Malignant gliomas are highly invasive primary brain tumors that are not known to metastasize outside the central nervous system (CNS). The median survival time of patients with glioma is only 6 months to 2 years depending on the variability in patient's condition, type of tumor and variable treatment parameters. In recent times, Gamma knife (GK) and temozolomide (TMZ) have showed a new dimension for the treatment of gliomas, even these modalities have not able to bring a paradigm shift in overall survival and morbidity. Despite the aggressive current therapeutic interventions such as surgery, radiotherapy and chemotherapy, improved therapeutic strategies/targets are greatly needed. Interactions between the tumor and its microenvironment are known to regulate malignancies and there is need to focus more research on these pathways in order to develop more reliable therapeutic strategies for the treatment of gliomas. It has also been shown that drug transporters are highly expressed by small population of most type of tumors, providing for a level of resistance which are relatively quiescent and show higher level of DNA repair, and a lowered ability to enter the apoptosis; can provide another therapeutic targets in most of the cancer types including gliomas. The alteration of miRNA expression profile in glioma has also been found to be associated with neoplastic agents, hence open a new direction for the treatment. Therefore, the present review has been focused on some of these new potential targets for therapeutic interventions in the prognosis and treatment of human glioma.

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Recent Approaches and Novel Therapeutic Targets in Human Glioma

Vishwakarma¹,

Paspala²,

Bardia³

et al. 2013

ACRT

View full text Add to dashboard Cite

show abstract

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Assessment of Rodent Glioma Models Using Magnetic Resonance Imaging Techniques

Cited by 1 publication

References 73 publications

Recent Approaches and Novel Therapeutic Targets in Human Glioma

Recent Approaches and Novel Therapeutic Targets in Human Glioma

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