Assessment of risk factors for the development of simple and complex non-atypical endometrial hyperplasia

Abstract

Annotation. Goal – to identify and assess the most significant risk factors for the development of simple non-atypical endometrial hyperplasia (SNAEH) and complex non-atypical endometrial hyperplasia (CNAEH) in women. Retrospective analysis of anamnestic data of 58 case histories of patients with SNAEH, 35 case histories of patients with CNAEH and data of 30 women of the control group, which allowed to identify risk factors for hyperproliferative processes of the endometrium (HPE) for research, the statistical significance of which was further assessed by calculating odds ratio (OR). The main feature associated with the risk of SNAEH is heredity – OR = 49.73 (95% CI 2.90–852.32). Significantly increases the risk of developing SNAEH in the presence of thyroid gland lesion (TGL) – OR = 34.97 (95% CI 2.03–601.20). The third in the hierarchical sequence is the polycystic ovary syndrome factor; OR = 25.72 (95% CI 1.488–444.59). Heredity occupies the top of the hierarchical structure in the group of patients with CNAEH. OR is 80.67 (95% CI 4.56–1424.76). A high probability of developing CNAEH is also observed for women over the age of 50 (OR = 32.44 (95% CI 1.82–576.56). In third place – the presence of TGL, which significantly increases the risk of developing CNAEH; OR = 28.63 (95% CI 1.60–510.56) Identification of statistically significant risk factors for the development of HPE will help to identify risk groups among the population, to carry out preventive measures among them (lifestyle adjustments, treatment of concomitant diseases) and decrease the incidence of the HPE.