Assessment of Risk Factors for Pancreatic Resection for Cancer

Abstract

A series of 101 consecutive patients undergoing pancreatic resection for cancer was retrospectively analyzed to define factors that may affect the immediate postoperative outcome. Overall morbidity and mortality were 28.7% and 10.9%, respectively, although these figures were greatly reduced during the last years; the complication rate dropped from 55.6% (1981-1987) to 20.0% (1993-1995) and the mortality from 16.7% to 6.7%. At univariate statistical analysis the patient characteristics (sex, age, American Society of Anesthesiologists [ASA] class, nutritional status, jaundice), tumor characteristics (site, size, TNM stage, and grading), and type of surgery were found not to affect postoperative morbidity and mortality. In contrast, a significantly lower rate of complications was observed in patients not undergoing gastric resection, in those who received 3 units or less of blood intraoperatively, and in subjects operated more recently (after 1990). At multivariate analysis the period when the operation was performed was the only independent variable that affected the immediate postoperative outcome. Among the examined factors, only the experience acquired over time regarding the intra- and perioperative treatment of these patients seems able to lower the rate of postoperative complications.

How to pass on expertise: Pancreatoduodenectomy at a teaching hospital

“…When compared to results in publications of only 20 years ago [5,7], the rates of short-term and long-term complications of PD have improved enormously during the last few years. Perioperatire mortality (30 dM) rates of 0 to 5% [3,8,11,12,[16][17][18][19][20][21] and an overall complication rate of less than 40% have been reported by several groups [3,21,[23][24][25][26].…”

Factors Associated with Survival after Surgical Resection in Chinese Patients with Ductal Adenocarcinoma of the Pancreatic Head

“…Thus, examining contributing factors has attracted substantial research interest in the past decades [14,15,16,17,18,19,20,21,22,23,24,25]. Tumor size [14,15,16,17], CA19-9 level [18, 19], preoperative pain [20, 21], lymph node infiltration [16, 17,21,22,23,24] and vascular invasion [24, 25] have been found to be significant predictors for recurrence. This has also been confirmed by our study.…”