Assessment of resting perfusion with myocardial contrast echocardiography: Theoretical and practical considerations

Lindner, Jonathan R.; Villanueva, Flordeliza S.; Dent, John; Wei, Kevin; Sklenar, Jiri; Kaul, Sanjiv

doi:10.1067/mhj.2000.100123

Cited by 37 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,20,21 After digital subtraction of the image obtained just before contrast agent administration (ie, baseline image) from the contrast image, variations in local image echogenicity can be minimized and, therefore, foster visual assessment of myocardial perfusion. However, the important prerequisite for such an approach is a match of the subtracted precontrast and postcontrast images, which is not completely achievable, despite the development of computer programs for image superimposition, because these images are obtained at different times and, therefore, are by definition not the same.…”

Section: Discussionmentioning

confidence: 99%

Parametric Detection and Measurement of Perfusion Defects in Attenuated Contrast Echocardiographic Images

Shiro

Chen²,

McMahon

et al. 2007

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objective. Attenuation of radio frequency (RF) signals limits the use of contrast echocardiography. The harmonic-to-fundamental ratio (HFR) of the RF signals compensates for attenuation. We tested whether HFR analysis measures the left ventricular nonperfused area under simulated experimental attenuation. Methods. Radio frequency image data from short axis systolic projections were obtained from 11 open-chest dogs with left anterior descending or left circumflex coronary artery occlusion followed by left atrial bolus injection of a perflutren microbubble contrast agent. Clinical attenuation was simulated by calibrated silicone pads interposed between the epicardial surface and the transducer to induce mild (7-dB) and severe (14-dB) reduction of the backscattered RF signals. Harmonic-to-fundamental ratio values were calculated for each image pixel for 0-, 7-, and 14-dB attenuation conditions and reproducibly showed a "perfused area" and a "nonperfused area." A reference nonperfused area was obtained by manual delineation in high-quality contrast scans. Results. Correlations of the HFRdetected and manually outlined perfusion defect areas were R = 0.92 for 0 dB, R = 0.94 for 7 dB, and R = 0.90 for 14 dB; the mean difference was less than 0.36 cm 2 (negligible) in all 3 attenuation settings. Conclusions. Attenuation compensation by our HFR method allows precise measurement of myocardial perfusion defect areas in contrast scans with simulated high level of attenuation. Key words: contrast echocardiography; harmonic ultrasound; myocardial perfusion; radio frequency signal; ultrasound attenuation. ontrast microbubbles are intravascular blood tracers that enhance myocardial circulation and provide a means for assessing the extent of perfusion defects in patients with myocardial ischemia during myocardial contrast echocardiographic scans. A specific scanning regimen, which induces destruction of microbubbles within the thickness of an ultrasonographic cross-sectional plane and measures their rate of replenishment, fosters the assessment of an ischemic area and allows quantitation of regional perfusion flow.1 Whether an experimental closed-chest setting or a clinical setting is evaluated, and whether a perfusion defect area is related to a completely or partially obstructed coronary artery, a common limitation exists: attenuation of the transmitted and received ultrasonic signals. This is a fundamental limitation of ultrasonography that contributes to heterogeneity in echogenicity and artifacts

show abstract

Section: Discussionmentioning

confidence: 99%

Parametric Detection and Measurement of Perfusion Defects in Attenuated Contrast Echocardiographic Images

Shiro

Chen²,

McMahon

et al. 2007

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

show abstract

“…Contrast agents may provide better images of the ventricles of the heart and larger blood vessels as well as visualization of microcirculation, which is interesting for detection of e.g. myocardial perfusion (Lindner et al, 2000). Targeted microbubbles that attach to specific molecular signatures may provide new possibilities for diagnosis of various diseases, e.g.…”

Section: Ultrasoundmentioning

confidence: 99%

Ultrasound in Abdominal Aortic Aneurysm

Brekken¹,

Dahl²,

Hernes³

2011

Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

View full text Add to dashboard Cite

“…[1][2][3][4] Due to these theoretical advantages of MCE over conventional tests, MCE is expected to be a useful modality for the early and accurate diagnosis of acute coronary syndrome in the emergency room, 5 but the clinical efficacy of MCE in the diagnosis of acute coronary syndrome has not been established in clinical trials. We examined the hypothesis that MCE is superior to conventional electrocardiographic and troponin level criteria for the early diagnosis of non-ST-segment elevation myocardial infarction and prediction of clinical events in patients who present with a suspected acute coronary syndrome.…”

mentioning

confidence: 99%

Efficacy of Myocardial Contrast Echocardiography in the Diagnosis and Risk Stratification of Acute Coronary Syndrome

Kang¹,

Kang²,

Song³

et al. 2005

The American Journal of Cardiology

View full text Add to dashboard Cite

Assessment of resting perfusion with myocardial contrast echocardiography: Theoretical and practical considerations

Cited by 37 publications

References 0 publications

Parametric Detection and Measurement of Perfusion Defects in Attenuated Contrast Echocardiographic Images

Parametric Detection and Measurement of Perfusion Defects in Attenuated Contrast Echocardiographic Images

Ultrasound in Abdominal Aortic Aneurysm

Efficacy of Myocardial Contrast Echocardiography in the Diagnosis and Risk Stratification of Acute Coronary Syndrome

Contact Info

Product

Resources

About