Assessment of residential environmental exposure to pesticides from agricultural fields in the Netherlands

Brouwer, Maartje; Kromhout, Hans; Vermeulen, Roel; Duyzer, J.H.; Kramer, H.; Hazeu, G.W.; Snoo, G. de; Huss, Anke

doi:10.1038/jes.2017.3

Cited by 42 publications

(35 citation statements)

References 32 publications

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“…Especially in the production of fruits and vegetables, there is a need to use different chemical products in order to ensure productivity and quality of crops. On the other hand, despite the usefulness of pesticides, their use imposes a range of risks, including potential harmful side effects on humans, residues in food crops, environmental pollution, development of resistance and outbreak of insect pests [ 1 , 2 , 3 ]. Actually, in order to increase the food safety and reduce the environmental impact of agricultural practices, there is an urgent need to develop new pest control agents that present improved characteristics in terms of selectivity, environmentally acceptability, biodegradability and safety of use.…”

Section: Introductionmentioning

confidence: 99%

Pimpinella anisum Essential Oil Nanoemulsion Toxicity against Tribolium castaneum? Shedding Light on Its Interactions with Aspartate Aminotransferase and Alanine Aminotransferase by Molecular Docking

et al. 2020

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The insecticidal activity is the result of a series of complex interactions between toxic substances as ligands and insect’s enzymes as targets. Actually, synthetic insecticides used in pest control programs are harmful to the environment and may affect non-target organisms; thus, the use of natural products as pest control agents can be very attractive. In the present work, the toxic effect of aniseed (Pimpinella anisum L.) essential oil (EO) and its nanoemulsion (NE) against the red flour beetle Tribolium castaneum, has been evaluated. To assess the EO mode of action, the impact of sub-lethal concentrations of aniseed EO and NE was evaluated on enzymatic and macromolecular parameters of the beetles, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, total lipids and glucose. Finally, a molecular docking study was conducted to predict the mode of action of the major EO and NE components namely E-anethole, Limonene, alpha-himalachalene, trans-Verbenol and Linalool at binding site of the enzymes AST and ALT. Herein, the binding location of the main compounds in both proteins are discussed suggesting the possible interactions between the considered enzymes and ligands. The obtained results open new horizons to understand the evolution and response of insect-plant compounds interactions and their effect predicted at the molecular levels and side effects of both animal and human.

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Section: Introductionmentioning

confidence: 99%

Pimpinella anisum Essential Oil Nanoemulsion Toxicity against Tribolium castaneum? Shedding Light on Its Interactions with Aspartate Aminotransferase and Alanine Aminotransferase by Molecular Docking

et al. 2020

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“…In other environmentally relevant organisms, such as drosophila and honeybees, atrazine turned out to be more of a concern because of evident lipid peroxidation and antioxidant depletion. CAT -catalase; FRAP -ferric reducing ability of plasma; GPx -glutathione peroxidase; GR -glutathione reductase; GSH -reduced glutathione; GST -glutathione S-transferase; SOD -superoxide dismutase; TBARS -thiobarbituric acid reactive species • -no change in oxidative stress marker; ↑ -increase; ↓ -decrease Živković Semren T, et al Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings Arh Hig Rada Toksikol 2018;69: [109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125] As for rodents, laboratory studies have confirmed the associations between the two triazines and oxidative stress found in aquatic organisms. They generally suggest that the antioxidant enzyme defences in rodents are compromised.…”

Section: Discussionmentioning

confidence: 99%

“…Accurate assessment of human exposure is one of the major challenges to epidemiological studies of health effects from pesticide exposure (109). Exposure in farmers is characterised by large seasonal differences in the type, amount, and frequency of pesticide application, as well as application technique, formulations used, environmental conditions, and personal behaviour of pesticide applicator (120,121). It is particularly challenging to asses exposure for individuals living in the vicinity of pesticide-treated fields or for the general population and to link it with health effects.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

Semren

Žunec

Pizent

2018

Archives of Industrial Hygiene and Toxicology

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This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. In laboratory mice and rats changes in oxidative stress markers were visible only with exposure to high doses of atrazine. Recently, our group reported that low-dose terbuthylazine could also induce oxidative stress in Wistar rats. It is evident that any experimental assessment of pesticide toxic effects should take into account a combination of several oxidative stress and antioxidant defence biomarkers in various tissues and cell compartments. The identified effects in experimental models should then be complemented and validated by epidemiological studies. This is important if we wish to understand the impact of pesticides on human health and to establish safe limits.

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“…Organophosphate pesticides (OPP), which are widely used to control diseases and pests over the long‐term, have been seriously threatening to the environment and human . In general, the contents of OPP residues are very low and the components are complicated in crops or environment, so that OPP residues cannot be easily detected in real samples . Therefore, it is important and necessary to ultrasensitively and selectively determine OPP residues.…”

Section: Introductionmentioning

confidence: 99%

“…More importantly, the limit‐of‐detection (LOD) values of the reported OPP analytic methods (containing electrochemical and non‐electrochemical methods) generally are within 0.12 pmol L −1 to 200 nmol L −1 . Nevertheless, the OPP residues of persisting in crops and environment may be lower . Therefore, it is of great significance to fabricate ultrasensitive and efficient OPP biosensor.…”

Section: Introductionmentioning

confidence: 99%

Rational Integration of Biomineralization, Microbial Surface Display, and Carbon Nanocomposites: Ultrasensitive and Selective Biosensor for Traces of Pesticides

Han

Chen

2018

Adv Materials Inter

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real-time detection, simple operation, high sensitivity, and miniaturization. [12,13] So far, the most of electrochemical OPP biosensors are based on the inhibiting effect of enzymes, particularly acetylcholinesterase (AChE). [14][15][16][17][18][19][20] However, the poor specificity of AChE and enzyme inhibition-based sensing mechanism can make electrochemical biosensors to have low selectivity, complicated analysis process, low sensitivity, and slow response, restricting their application. In addition, many electrochemical OPP sensors were applied at positive potential, based on oxidation currents of analytes, [21,22] where some antioxidants in real samples can also be oxidized. More importantly, the limit-of-detection (LOD) values of the reported OPP analytic methods (containing electrochemical and non-electrochemical methods) generally are within 0.12 pmol L −1 to 200 nmol L −1 . [5,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] Nevertheless, the OPP residues of persisting in crops and environment may be lower. [4,5] Therefore, it is of great significance to fabricate ultrasensitive and efficient OPP biosensor.To overcome these above problems, organophosphate hydrolase (OPH) is introduced into electrochemical OPP biosensors to substitute enzyme inhibition-based biosensors. [35] OPH can specifically hydrolyze organophosphate compounds, where OPP are the substrate of the enzyme rather than the inhibitor. [1,36] Hence, OPH-based analytical methods generally show good selectivity and simple assay procedure. However, there are relatively few reports about the electrochemical biosensor based on OPH, compared with other biosensors. [27,37] In previous work, we prepared OPH-fused cell-cobalt phosphate (CP) bioinorganic hybrid materials, that is, mineralized cell (M-Cell), for enhancing the activity of OPH by the integration of allosteric effect, [38,39] biomineralization technology, [40] and cell surface display technology. [16] However, concomitantly, inorganic salt (CP) and whole-cell can reduce the conductivity and electrochemical activity of M-Cell hybrid catalysts. Therefore, it is interesting and necessary to improve the electrochemical activity of M-Cell hybrid catalysts in order to establish the electrochemical OPP biosensor with ultrasensitivity.As is well known, carbon nanotube (CNT) is extensively used to construct electrochemical biosensors, due to the large specific surface area, good stability, and high conductivity. [41] However, Nowadays, the over misuse of organophosphate pesticides (OPP) has seriously threatened human health and environment, and it is challenging and indispensable to establish biosensor for supersensitive, reliable, and fast detection of traces of OPP in real samples. This work provides an interdisciplinary strategy for the construction of electrochemical OPP biosensor with supersensitivity, high selectivity, simple operation, and fast response. First, amino acid ionic liquid (AAIL) is used as stabilizer to dramatically improve the dispersibility of carbon nanotube (CNT) i...

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Assessment of residential environmental exposure to pesticides from agricultural fields in the Netherlands

Cited by 42 publications

References 32 publications

Pimpinella anisum Essential Oil Nanoemulsion Toxicity against Tribolium castaneum? Shedding Light on Its Interactions with Aspartate Aminotransferase and Alanine Aminotransferase by Molecular Docking

Pimpinella anisum Essential Oil Nanoemulsion Toxicity against Tribolium castaneum? Shedding Light on Its Interactions with Aspartate Aminotransferase and Alanine Aminotransferase by Molecular Docking

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

Rational Integration of Biomineralization, Microbial Surface Display, and Carbon Nanocomposites: Ultrasensitive and Selective Biosensor for Traces of Pesticides

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