Assessment of replication of research evidence from animals to humans in studies on peri-implantitis therapy

Assessment of endpoints in studies on peri-implantitis treatment—A systematic review

“…42,43 This is particularly important for clinicians making a clinical decision for their patients or for guideline developers assessing the evidence and strength of a recommendation of a clinical procedure. 42 The correct plan- Assessed, after probing, at four to six sites (score 0 = no bleeding when a periodontal probe is passed along the gingival margin adjacent to the implant, score 1 = isolated bleeding spot visible, score 2 = red line of blood on margin, score 3 = heavy bleeding) ning of study design, 44 including the determination of endpoints, is vital for improvement of the body of evidence on the efficacy of peri-implantitis interventions.…”

Guidelines for Reporting Pre-clinical In Vitro Studies on Dental Materials

“…Replication is regarded as one of the cornerstones of inference from experimental studies. 22,23 Specific information on the type of intervention performed in the control and test groups should be described in detail. For example, when testing the effect of different adhesive systems on the surface of extracted human teeth, information on how the test specimens were prepared, etching time, procedures used to apply the adhesive, polymerization time, etc., should be provided.…”

Animal research as a basis for clinical trials

“…Another important parameter to consider when designing a research study is the calculation of sample size and power . Sample size contributes to the reliability of precision measurements rather than to bias , and evidence suggests that authors of animal experiments in implant dentistry often do not calculate the sample size . For experiments aiming to determine quantitative differences between groups or therapies, an a priori calculation of sample size is recommended to avoid type II errors.…”