Assessment of Repeatability of Hyperpolarized Gas MR Ventilation Functional Imaging in Cystic Fibrosis

O’Sullivan, Brian; Couch, Marcus J.; Roche, John P.; Walvick, Ronn P.; Zheng, Shaokuan; Baker, Dawn; Johnson, Martin P.; Botfield, Martyn C.; Albert, Mitchell S.

doi:10.1016/j.acra.2014.07.008

Cited by 35 publications

(30 citation statements)

References 34 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sequential images provide quantitative information about lung function through the regional quantitation of ventilation volume relative to total volume (VV) and ventilation defects per image can then be presented as percentages of total area. The reproducibility of the analysis and technique has been measured at 96% [35,36]. The HP 3 He MRI results correlate strongly with spirometry values (r = 0.89, p < 0.01) and HRCT (r = 0.89, p < 0.01), and there is also a trend to correlate with chest X-ray (r = −0.38, p < 0.06) in adults with Cystic Fibrosis.…”

Section: Hyperpolarized Helium-3 Mrimentioning

confidence: 94%

“…Following this, hyperpolarized helium-3 MRI (HP 3 He MRI) has been examined in multiple settings and has shown high sensitivity for the detection of ventilation impairments [34][35][36][37][38][39][40][41][42][43][44]. This typically requires production of hyperpolarized gas on site which is then mixed with nitrogen and administered to patients with a one litre Tedlar Bag.…”

Section: Hyperpolarized Helium-3 Mrimentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of high resolution computed tomography findings of cystic fibrosis

Şaşihüseyinoğlu

Altıntaş

Soyupak

et al. 2019

Korean J Intern Med

View full text Add to dashboard Cite

Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current 'gold standard' method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis. X-ray phase-contrast imaging is another emerging X-ray based methodology for Cystic Fibrosis lung assessment which provides dynamic morphological and functional information, albeit with even higher X-ray doses than HRCT. Magnetic Resonance Imaging (MRI) is a non-ionising radiation imaging method that is garnering growing interest among researchers and clinicians working with Cystic Fibrosis patients. Recent advances in MRI have opened up the possibilities to observe lung function in real time to potentially allow sensitive and accurate assessment of disease progression. The use of hyperpolarized gas or non-contrast enhanced MRI can be tailored to clinical needs. While MRI offers significant promise it still suffers from poor spatial resolution and the development of an objective scoring system especially for ventilation assessment.

show abstract

Section: Hyperpolarized Helium-3 Mrimentioning

confidence: 94%

Section: Hyperpolarized Helium-3 Mrimentioning

confidence: 99%

Evaluation of high resolution computed tomography findings of cystic fibrosis

Şaşihüseyinoğlu

Altıntaş

Soyupak

et al. 2019

Korean J Intern Med

View full text Add to dashboard Cite

show abstract

“…Several groups have performed HP 3 He MRI in CF patients (mostly adults) in order to investigate regional defects in ventilation (13–16), HP gas repeatability (17,18), longitudinal ventilation changes (19), and treatment efficacy (20–23). Use of 129 Xe in pediatrics is more restricted than 3 He due to its slightly higher Ostwald solubility (ratio of gas volume absorbed by a liquid to the liquid volume) and thus greater anesthetic effect at high doses, but recent studies have shown that single-breath- holds of sub-anesthetic doses of Xe present no safety concerns in adults (24) or children (25).…”

Section: Introductionmentioning

confidence: 99%

Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients

Thomen

Walkup

Roach

et al. 2017

Journal of Cystic Fibrosis

115

129

View full text Add to dashboard Cite

Background Cystic fibrosis (CF) is a genetic disease which carries high morbidity and mortality from lung-function decline. Monitoring disease progression and treatment response in young patients is desirable, but serial imaging via CT is often considered prohibitive, and detailed functional information cannot be obtained using conventional imaging techniques. Hyperpolarized 129Xe magnetic resonance imaging (MRI) can depict and quantify regional ventilation, but has not been investigated in pediatrics. We hypothesized that 129Xe MRI is feasible and would demonstrate ventilation defects in mild CF lung disease with greater sensitivity than FEV1. Methods 11 healthy controls (age 6–16 years) and 11 patients with mild CF (age 8–16 years, Forced Expiratory Volume (FEV1) percent predicted >70%) were recruited for this study. Nine CF patients had an FEV1>85%. Each subject was imaged via hyperpolarized 129Xe MRI, and the ventilation defect percentage (VDP) was measured. Recent FEV1 and VDP were compared between the groups. Results FEV1 for controls was 100.3%±8.5% (mean ± sd) and for CF patients was 97.9%±16.0% (p=0.67). VDP was 6.4%±2.8% for controls and 18.3%±8.6% for CF (p<0.001). When considering the 9 CF patients with normal FEV1 (>85%), the mean FEV1 was 103.1%±12.3% (p=0.57 compared to controls) and VDP was 15.4% ± 6.3% (p=0.002). Conclusions Hyperpolarized 129Xe MRI demonstrated ventilation defects in CF patients with normal FEV1 and more effectively discriminated CF from controls than FEV1. Thus 129Xe may be a useful outcome measure to detect mild CF lung disease and to investigate regional lung function in pediatric lung diseases and to follow disease progression.

show abstract

“…The sequential images provide quantitative information about lung function through the regional quantitation of ventilation volume relative to total volume (VV) and ventilation defects per image can then be presented as percentages of total area. The reproducibility of the analysis and technique has been measured at 96% [35, 36]. The HP 3 He MRI results correlate strongly with spirometry values ( r = 0.89, p < 0.01) and HRCT ( r = 0.89, p < 0.01), and there is also a trend to correlate with chest X-ray ( r = −0.38, p < 0.06) in adults with Cystic Fibrosis.…”

Section: Novel Respiratory Imaging Research Applicationsmentioning

confidence: 99%

Lung function imaging methods in Cystic Fibrosis pulmonary disease

et al. 2017

View full text Add to dashboard Cite

Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current ‘gold standard’ method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis. X-ray phase-contrast imaging is another emerging X-ray based methodology for Cystic Fibrosis lung assessment which provides dynamic morphological and functional information, albeit with even higher X-ray doses than HRCT. Magnetic Resonance Imaging (MRI) is a non-ionising radiation imaging method that is garnering growing interest among researchers and clinicians working with Cystic Fibrosis patients. Recent advances in MRI have opened up the possibilities to observe lung function in real time to potentially allow sensitive and accurate assessment of disease progression. The use of hyperpolarized gas or non-contrast enhanced MRI can be tailored to clinical needs. While MRI offers significant promise it still suffers from poor spatial resolution and the development of an objective scoring system especially for ventilation assessment.

show abstract

Assessment of Repeatability of Hyperpolarized Gas MR Ventilation Functional Imaging in Cystic Fibrosis

Cited by 35 publications

References 34 publications

Evaluation of high resolution computed tomography findings of cystic fibrosis

Evaluation of high resolution computed tomography findings of cystic fibrosis

Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients

Lung function imaging methods in Cystic Fibrosis pulmonary disease

Contact Info

Product

Resources

About