Assessment of renal tissue elasticity by acoustic radiation force impulse quantification with histopathological correlation: preliminary experience in chronic kidney disease

Wang, Liang; Xia, Peng; Lv, Ke; Han, Jie; Dai, Qi; Li, Xuemei; Chen, Limeng; Jiang, Yuxin

doi:10.1007/s00330-014-3162-5

Cited by 93 publications

(97 citation statements)

References 25 publications

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“…Other studies published so far, comparing histological results with elastography in native kidneys, did not reach similar conclusions: Wang et al found no correlation of kidney SWV with: interstitial fibrosis, tubular atrophy, glomerulosclerosis index [9], while Cui et al found that renal fibrosis is associated with an increase of SWV [22].…”

Section: Discussionmentioning

confidence: 87%

“…Despite the fact that elastography is an accurate approach to liver fibrosis grading, data published so far regarding the influence of specific histological changes on the renal stiffness is quite scarce [9]. The aim of the present study is to assess the relationship between kidney SWV and chronic histological changes (glomerulosclerosis, interstitial fibrosis, arteriolo-hyalinosis) in patients diagnosed with chronic glomerulonephritis (CGN).…”

Section: Introductionmentioning

confidence: 99%

“…The use of ultrasound based elastography is becoming important in the non-invasive assessment of different organs: liver fibrosis [1,2], spleen stiffness, for predicting portal hypertension [3,4], thyroid nodules [5,6], prostate [7], focal liver lesions [8], or chronic kidney disease [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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Aim: To analyze the relationship between shear wave velocity in the kidney measured by point shear wave elastography using Virtual Touch Quantification (VTQ) (Siemens Acuson S2000) and histological parameters obtained from renal biopsies, in patients with chronic glomerulonephritis (CGN).Material and methods: The study group included 20 patients (mean age 47.95±13.59 years) with different types of CGN, that had underwent renal biopsy and 57 normal controls (mean age 38.07±17.32 years). In all patients, five valid stiffness measurements were obtained in each kidney, with the patient in lateral decubitus. Regarding the histological results, we assessed the presence or absence of glomerulosclerosis, interstitial fibrosis, and arteriolo-hyalinosis.Results: In patients with CGN we obtained the following mean values of VTQ values: right kidney: 2.12±0.81 m/s, left kidney 1.65±0.54 m/s, while in the normal controls significantly higher VTQ values were obtained: right kidney 2.69±0.72 m/s (p=0.004), left kidney 2.48±0.73 m/s (p<0.0001). In patients with CGN no statistically significant correlations between VTQ values and eGFR (r=0.37, p=0.12) or proteinuria (r=0.2, p=0.37) were found. We found significantly lower VTQ values in patients with interstitial fibrosis (1.46 vs. 1.99 m/s, p<0.05) and also in patients with arteriolo-hyalinosis (1.55 vs. 2.47 m/s, p<0.05).Conclusion: Our pilot study shows that shear wave velocity values in patients with CGN are significantly lower compared to normal controls, and there is a tendency to decrease with the decrease of eGFR, with the presence of interstitial fibrosis and of arteriolo-hyalinosis.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

View full text Add to dashboard Cite

show abstract

“…The Aixplorer system is good for kidney applications by using real-time and continuous color mapping, when the continuous motion due to arterial pulsation and respiration and the small size of the kidney are considered. Even though there are no data comparing the Aixplorer system to systems from other vendors in terms of kidney elastography, acoustic radiation force impulse imaging with the Acuson S2000 system (Siemens AG, Erlangen, Germany) has also been used for human kidneys 35 ; thus, that method is feasible for kidney applications as well. However, real-time elastography, virtual touch imaging, and virtual quantification are not available at the same time.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Kidney Fibrosis Using Ultrasonic Shear Wave Elastography

Moon

Kim

Cho

et al. 2015

J of Ultrasound Medicine

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Objectives The purpose of this study was to evaluate the feasibility of ultrasonic shear wave elastography for quantification of renal fibrosis in an experimental rabbit model. Methods Thirty‐eight kidneys of 19 rabbits were studied and categorized into 3 groups: group I, ureter obstruction (n = 9); group II, renal vein occlusion (n = 10); and group III, normal control (n = 19). Before surgery, we measured stiffness at the renal cortex using shear wave elastography and evaluated the sonographic findings, including size, echogenicity, and resistive index. We repeated the same sonographic examinations weekly until the fourth week. The degree of histologically quantified fibrosis and the measured stiffness values were statistically compared. Results There was no significant difference in the mean stiffness values for the renal cortex in the 3 groups before surgery (8.95 kPa in group I, 9.06 kPa in group II, and 9.74 kPa in group III; P > .05). However, the mean stiffness in each group on the last sonographic examination was significantly different (10.91 kPa in group I, 13.92 kPa in group II, and 9.77 kPa in group III; P = .003). Pathologically, the degree of fibrosis was also significantly different (3.62% in group I, 11.70% in group II, and 0.70% in group III; P< .001). The fibrosis degree and stiffness were positively correlated (ρ = 0.568; P = 0.01). Conclusions Tissue stiffness measured by ultrasonic shear wave elastography was positively correlated with histopathologic renal fibrosis. Ultrasonic shear wave elastography may be used as a noninvasive tool for predicting renal fibrosis.

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“…There are only a small number of studies in which US strain and shear modulus-based elastography are used to evaluate the kidneys (9)(10)(11)(13)(14)(15)(16), and the majority of these studies have been performed in adults. There are several possible causes of altered renal stiffness, including parenchymal fibrosis (10,13,14) and hydronephrosis (11,12).…”

Section: Discussionmentioning

confidence: 99%

Can Shear-Wave Elastography be Used to Discriminate Obstructive Hydronephrosis from Nonobstructive Hydronephrosis in Children?

Dillman¹,

Smith²,

Davenport³

et al. 2015

Radiology

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Assessment of renal tissue elasticity by acoustic radiation force impulse quantification with histopathological correlation: preliminary experience in chronic kidney disease

Cited by 93 publications

References 25 publications

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Quantification of Kidney Fibrosis Using Ultrasonic Shear Wave Elastography

Can Shear-Wave Elastography be Used to Discriminate Obstructive Hydronephrosis from Nonobstructive Hydronephrosis in Children?

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