Assessment of renal function using cystatin C and creatinine in Saudi patients after transplantation

Jeraiby, Mohammed

doi:10.4103/aam.aam_67_20

Cited by 4 publications

(5 citation statements)

References 22 publications

(24 reference statements)

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“…[26][27][28][29] Cystatin C can quickly reflect small changes in glomerular filtration rate and has higher specificity and sensitivity for early renal function damage. 30 In this study, there was a significant increase in urine volume in the early postoperative period between the two groups of patients, and there was no statistically significant difference compared to the same period; Compared with the 1 day before operation, the concentrations of urea, creatinine, and cystatin C in the serum of both groups of patients significantly decreased 7 days after operation, and the glomerular filtration rate increased. Judging from the above indicators, there was a significant improvement in early postoperative kidney transplant function in both groups of patients, indicating that the two groups of sedative drugs did not have a significant impact on the improvement of early postoperative kidney transplant function in kidney transplant patients.…”

mentioning

confidence: 49%

Effect of Remimazolam on Induction and Maintenance of General Anesthesia in Kidney Transplant Patients

Chen,

Qin,

et al. 2024

IJGM

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This study aims to evaluate the effect of remimazolam on induction and maintenance of general anesthesia in kidney transplant patients. Methods: 120 patients undergoing kidney transplant were divided into two groups: Propofol group (Group P) and Remimazolam group (Group R). Anesthesia induction: remimazolam had injected IV at a dose of 0.15-0.35 mg/kg in Group R, while propofol had injected IV at a dose of 2.0-2.5 mg/kg in Group P. Anesthesia maintenance: remimazolam was injected IV at a dose of 0.3-1.0 mg•kg −1 •h −1 and propofol was injected IV at a dose of 1-12 mg•kg −1 •h −1 in Group R, propofol was injected IV at a dose of 3-12 mg•kg −1 •h −1 in Group P. All patients have the same remaining anesthesia durgs. Results: Compared with Group P, in Group R the time of disappearance of the eyelash reflex and the time to drop to 60 in BIS was longer (P < 0.05), the time of awakening was shorted (P < 0.05), the MAP of T 6 was fluctuated less (P < 0.05), the incidence of hypotension and injection pain during induction was reduced (P < 0.001), the incidence of intraoperative bradycardia during operation was reduced (P < 0.05), the dosages of sedatives drug during maintenance was reduced (P < 0.05). There was no statistically significant difference in postoperative renal function between the two groups of patients (P > 0.05). Conclusion:Remimazolam can be safely and effectively used for the induction and maintenance of general anesthesia in kidney transplant patients.

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confidence: 49%

Effect of Remimazolam on Induction and Maintenance of General Anesthesia in Kidney Transplant Patients

Chen,

Qin,

et al. 2024

IJGM

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“…Thus, serum creatinine and cystacin C may be markers of renal dysfunction after transplantation. 5 The age of the donor and the patient determine the survival rate of the transplanted organ. The ageing process of renal tissue begins after the donor reaches the age of 35.…”

Section: Resultsmentioning

confidence: 99%

“…4 Endogenous markers for diagnosis, monitoring treatment efficacy and predicting kidney transplant survival have attracted the interest of scientists and clinicians due to their speed and ease of detection. In particular, Jeraiby 5 emphasised serum creatinine concentration, cystatin C and determination of glomerular filtration rates by enzymolysis and recalculation formulae.…”

Section: Introductionmentioning

confidence: 99%

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Review of prognostic factors for kidney transplant survival

Zulkhash,

Shanazarov,

Kissikova

et al. 2023

Urologia

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Transplantation is the most effective treatment for end-stage chronic kidney disease, as this procedure prolongs and improves the patient’s quality of life. One of the key problems is the risk of graft rejection. The purpose of this research was to identify and analyse prognostic factors that will prevent rejection. In particular, the prognostic factors grouped by methods of synthesis, generalisation and statistical processing with calculation and graphical representation of hazard ratio and correlation coefficient were grouped, namely: age of donor and recipient, time of cold kidney ischaemia, duration of preoperative dialysis, body mass index, presence of concomitant diseases (diabetes mellitus, hypertension), primary causes causing transplantation. Several molecular genetic and biochemical prognostic markers (transcription factors, immunocompetent cell signalling and receptors, cytostatin C, creatinine, citrate, lactate, etc.) are annotated. It has been demonstrated that creatinine reduction rate determines the risk of rejection, displaying the dynamics of cystatin C and creatinine changes in the postoperative period. Young recipients who underwent prolonged preoperative dialysis were identified as having the highest risk of rejection. Diabetes and hypertension bear a non-critical but commensurately equal risk of rejection. The survival rate of the graft is better when transplanted from a living donor than from a deceased donor. A correlation between cold ischaemia time, body mass index and the probability of graft failure has been proven, namely, the greater the donor and recipient body mass index and the longer the cold ischaemia time, the lower the chance of successful long-term organ acclimation. The data obtained can be used as prognostic factors for graft accommodation at different intervals after surgery.

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“…Despite a significant correlation being observed between Cys C and serum creatinine, the strength of the correlation was weak. A modest correlation has been reported between serum creatinine and Cys C [ 28 ] . Differences in the estimation technique of serum creatinine have also been observed to influence this correlation [ 29 ] .…”

Section: Discussionmentioning

confidence: 99%

Correlations between serum kidney injury molecule-1, cystatin C and immunosuppressants: A cross-sectional study of renal transplant patients in Bahrain

Sridharan¹,

Shah²,

Hammad³

et al. 2024

J Biomed Res

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Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for treatment. Serum creatinine is the standard for monitoring kidney function; however, cystatin C (Cys C) and kidney injury molecule-1 (KIM-1) have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney function. Here, we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil, tacrolimus, sirolimus, everolimus, or cyclosporine to evaluate kidney function. We used both the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation, which is based on creatinine and combined creatinine with Cys C, and the CKD-EPI 2012 equation, which is based on Cys C alone, to estimate glomerular filtration rate (GFR). Then, we assessed the association between serum KIM-1 and GFR < 90 mL per minute per 1.73 m 2 . We observed significantly higher serum Cys C levels in patients with the elevated serum creatinine, compared with those with normal serum creatinine. The estimated GFRs based on creatinine were significantly higher than those based on the other equations, while a significant positive correlation was observed among all equations. Serum KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations. A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR < 90 mL per minute per 1.73 m 2 . We observed a significant correlation between serum creatinine and Cys C in our renal transplant patients. Therefore, serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

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Assessment of renal function using cystatin C and creatinine in Saudi patients after transplantation

Cited by 4 publications

References 22 publications

Effect of Remimazolam on Induction and Maintenance of General Anesthesia in Kidney Transplant Patients

Effect of Remimazolam on Induction and Maintenance of General Anesthesia in Kidney Transplant Patients

Review of prognostic factors for kidney transplant survival

Correlations between serum kidney injury molecule-1, cystatin C and immunosuppressants: A cross-sectional study of renal transplant patients in Bahrain

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