Assessment of Renal Function in the Young: Special Considerations

Hurley, R. Morrison

doi:10.1016/s0272-2712(18)30473-6

Clinics in Laboratory Medicine

1993

DOI: 10.1016/s0272-2712(18)30473-6

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Assessment of Renal Function in the Young: Special Considerations

R. Morrison Hurley

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2006

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“…32 In practice creatinine clearance in people provides a relatively accurate estimation of GFR when renal function is normal due to cancellation of errors; the overestimation due to tubular secretion is offset by the underestimation due to falsely elevated plasma measurement. 36,40,44 Ideally, a peroxidasecoupled enzymatic method should be used in animals for measuring creatinine levels, as this is not affected by non-creatinine chromogens and avoids this potential inaccuracy. 32 A variation of urinary excretion methods for determining clearance is use of plasma clearance rates to estimate GFR.…”

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Effect of Nephrotomy on Renal Function and Morphology in Normal Cats

et al. 2006

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Objective:To assess effects of bisection nephrotomy on renal function, size, and morphology in cats over a period of 12 weeks. Study Design:Controlled, randomized, blinded experiment. Sample Population:Ten adult female cats. Methods:Glomerular filtration rate (GFR), as determined by quantitative renal scintigraphy using Results:No significant differences in mean GFR and kidney size of the operated versus unoperated kidneys were observed at any time period. Individual GFR and renal size of all except one of the cats remained within normal limits. Two additional cats had evidence of transient ureteral obstruction in the immediate post-operative period. No significant histologic abnormalities were observed in any biopsy. Conclusions:Bisection nephrotomy in normal cats did not adversely affect renal function or morphology over the three month post-operative period. Clinical Relevance:Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in animals with pre-existing renal insufficiency are needed to insure no adverse effects would occur in clinical cases where this surgical procedure is warranted.

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Effect of Nephrotomy on Renal Function and Morphology in Normal Cats

et al. 2006

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Assessment of Renal Function in the Young: Special Considerations

Cited by 1 publication

References 73 publications

Effect of Nephrotomy on Renal Function and Morphology in Normal Cats

Effect of Nephrotomy on Renal Function and Morphology in Normal Cats

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