Assessment of Renal and Hepatic Tissue-Protective Effects of N-Acetylcysteine via Ammonia Metabolism: A Prospective Randomized Study

Önk, Didem; Özçeli̇k, Fatih; Onk, Oruç Alper; Günay, Murat; Ayazoğlu, Tülin Akarsu; Unver, Ethem

doi:10.12659/msm.908172

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…Similar work in poultry is limited. However, in mammals, NAC was demonstrated to decrease BUN and improve kidney function through regulation of ammonia and nitrogen metabolism [22,23].…”

Section: Discussionmentioning

confidence: 99%

Effects of N-acetylcysteine on the energy status and antioxidant capacity in heart and liver of cold-stressed broilers

Peng

Liao

et al. 2020

Asian-Australas J Anim Sci

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Objective: Cold stress induces oxidative damage and impairs energy status of broilers. N-acetylcysteine (NAC) exhibits antioxidant properties and modulates energy metabolism of animals. This study was conducted to investigate the effects of NAC on energy status and antioxidant capacity of heart and liver in the cold-stressed broilers. Methods: The experiment consisted of 4 treatments in a 2×2 factorial arrangement with two diets (basal diet or plus 0.1% NAC) and two ambient temperatures (thermoneutral [conventional ambient temperature] or cold stress [10°C±1°C during days 15 to 42]). Results: No ascites were seen in cold-stressed broilers. NAC did not attenuate the impaired growth performance of stressed birds. However, NAC decreased plasma asparagine but increased aspartate levels in cold-stressed birds (p<0.05). NAC reduced hepatic adenosine triphosphate (ATP) but elevated adenosine diphosphate contents in unstressed birds (p< 0.05). The hepatic ratio of adenosine monophosphate (AMP) to ATP was increased in birds fed NAC (p<0.05). NAC decreased plasma malondialdehyde (MDA) level and cardiac total superoxide dismutase (T-SOD) activity in unstressed birds, but increased hepatic activities of T-SOD, catalase and glutathione peroxidase in stressed birds (p<0.05). NAC down-regulated hepatic AMP-activated protein kinase but up-regulated cardiac heme-oxigenase mRNA expression in stressed birds, and decreased expression of hepatic peroxisome proliferatoractivated receptor coactivator-1α as well as hypoxia-inducible factor-1α in liver and heart of birds. Conclusion: Dietary NAC did not affect energy status but enhanced the hepatic antioxidant capacity by increasing the activities of antioxidant enzymes in cold-stressed broilers.

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“…Similar work in poultry is limited. However, in mammals, NAC was demonstrated to decrease BUN and improve kidney function through regulation of ammonia and nitrogen metabolism [22,23].…”

Section: Discussionmentioning

confidence: 99%

Effects of N-acetylcysteine on the energy status and antioxidant capacity in heart and liver of cold-stressed broilers

Peng

Liao

et al. 2020

Asian-Australas J Anim Sci

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“…There is a lack of similar work in poultry. NAC, but in the other hand, has been shown in mammals to improve kidney function by regulating ammonia and nitrogen metabolism [39]. NAC is an L-cysteine precursor which is used in the synthesis of reduced glutathione (GSH).…”

Section: Discussionmentioning

confidence: 99%

The Protective Role of N-Acetyl Cysteine (Nac) on Broilers Exposed to Chronic Heat Stress

Zahran

Hagag²,

Ramadan³

et al. 2021

Alfarama Journal of Basic & Applied Sciences

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In hot areas, heat stress (HS) is one of the most prominent stressors in the broiler industry. To provide comprehensive information about the effect of N-acetyl cysteine (NAC) on hamartiology, biochemistry, and thyroid hormones in broilers under thermoneutral (TN) (22 4 ° C) and heat stress (HS) (34 2 ° C), The current study was carried out. A total of 80 one-day-old Cobb broiler chicks were used, with 20 birds in each group receiving either a control (basal diet) or a NAC (100 mg/Kg diet). Chronic HS at 42 days resulted in a considerable decrease in HGB, PCV, RBCs, total protein, Albumin, serum T3 and T4, while greatly increasing H/L, triglycerides, cholesterol, LDL-cholesterol, uric acid, AST, ALT, ALP, TBIL, DBIL, and creatinine. When compared to HSC broilers at 42 d old, NAC supplementation greatly increased PCV content with a substantial decrease in total leukocytic count, heterophils, and H/L ratio with an increase in lymphocytes and monocytes. When compared to HSC population, chickens given NAC had a significant decrease in serum AST, ALP, ALT and triglyceride levels, as well as a significant increase in serum T3 concentration.

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“…Didem Onk, et al, showed that the pretreatment by N-acetylcysteine can improve hepatic functions by regulation of the metabolism of the ammonia and nitrogen, and reduction of lactate in patients with chronic obstructive pulmonary disease who undergo coronary artery bypass grafting surgery (14).…”

Section: Discussionmentioning

confidence: 99%

The Effect of N-acetyl Cysteine on Liver Function after On-pump Coronary Artery Bypass Graft Surgery: A Double-Blind Randomized Clinical Trial

Javaherforooshzadeh

Hormozi

Akhondzadeh

et al. 2021

Preprint

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Purpose: Somebody's organ dysfunctions such as heart, lung, kidney, and liver dysfunction are associated with the cardiopulmonary bypass in open-heart surgery.This study aimed effect of the N-acetyl cysteine injection on liver function after on-pump Coronary Artery Bypass Graft SurgeryMethod: In this clinical trial conducted in Golestan Hospital, Ahvaz, Iran, 60 candidates for coronary artery bypass graft surgery were selected based on the inclusion criteria. The candidates were then randomly divided into two intervention and control groups (30 people each).Intervention: Patients received 3 (2 intraoperative and 1 postoperative) doses of IV N-acetyl cysteine (100 mg/kg) (n=30) or placebo (n=30) over 24 hour. The main outcomes were serum Alkaline Phosphatase, Aspartate Aminotransferase, Alanine Aminotransferase, Bilirubin, PTT, and INR at 4 and 48 hours after surgery. Statistical analysis: The dates were analyzed using SPSS 22. Descriptive statistics were reported as mean ± standard deviation for continuous variables and as frequency and percentage for categorical variables. An unpaired t-test was used to compare the parameters with a normal distribution. Statistical significance level was defined at p-value < 0.05.Results: there were significant differences in terms of, ALT, AST, ALP and Bilirubin levels 4(p-value < 0.001) and 48h after surgery (p-value = 0.002).Conclusion: Based on the findings, intravenous administration of N-acetyl cysteine in patients with CABG significantly may be preserved liver function. Trial registry: Registered under No. Trial registration number IRCT20190506043492N2, date of registration :2020.05.23 .Retrospectively registered

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Assessment of Renal and Hepatic Tissue-Protective Effects of N-Acetylcysteine via Ammonia Metabolism: A Prospective Randomized Study

Cited by 11 publications

References 32 publications

Effects of N-acetylcysteine on the energy status and antioxidant capacity in heart and liver of cold-stressed broilers

Effects of N-acetylcysteine on the energy status and antioxidant capacity in heart and liver of cold-stressed broilers

The Protective Role of N-Acetyl Cysteine (Nac) on Broilers Exposed to Chronic Heat Stress

The Effect of N-acetyl Cysteine on Liver Function after On-pump Coronary Artery Bypass Graft Surgery: A Double-Blind Randomized Clinical Trial

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