Assessment of remodeling in chronic obstructive pulmonary disease using imaging methods

Soja, Jerzy; Łoboda, Piotr; Mikrut, S.; Ćmiel, Adam; Gross‐Sondej, Iwona; Górka, Karolina; Kasper, Łukasz; Andrychiewicz, Anna; Pulka, Grażyna; Reid, Michal; Sładek, Krzysztof

doi:10.20452/pamw.3047

Cited by 5 publications

(18 citation statements)

References 6 publications

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“…2 Early diagnosis is crucial to encourage smoking cessation, appropriate pharmacotherapy, and physical exercise. 4,5 The diagnosis of COPD increases the risk of and mortality from cardiovascular diseases by an odds ratio of 2.7 and 1.68, respectively. 6 The prevalence of coronary artery disease (CAD) among patients with COPD is estimated at 10% to 23%, 7 while its incidence among patients undergoing PCI-at 2.4% to 10%.…”

Section: Results Characteristics Of Patients With and Without Chronicmentioning

confidence: 99%

Chronic obstructive pulmonary disease affects the angiographic presentation and outcomes of patients with coronary artery disease treated with percutaneous coronary interventions

Januszek¹,

Siudak²,

Dziewierz³

et al. 2017

Polish Archives of Internal Medicine

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INTRODUCTION The incidence of chronic obstructive pulmonary disease (COPD) in patients treated with percutaneous coronary intervention (PCI) is underestimated, and the effect of COPD on atherosclerosis and the outcomes of PCI is not fully understood. OBJECTIVES The aim of this study was to assess the impact of COPD on periprocedural outcomes of PCI, as well as its relationship with clinical presentation and the type of coronary artery lesions. PATIENTS AND METHODS Data were prospectively collected using a national electronic registry of PCI procedures performed in Poland between January 2015 and December 2016. Out of the 221 187 PCIs, 5594 patients had been diagnosed with COPD before the intervention. RESULTS Patients with COPD were older than those without COPD (mean [SD] age, 70.3 [9.9] years vs 67 [10.8] years; P <0.001) and more often were males (72.3% vs 67.8%; P <0.001). Non-ST‑segment elevation myocardial infarction (NSTEMI) was a more common clinical presentation of coronary artery disease (CAD) in the COPD group, while ST‑segment elevation myocardial infarction (STEMI) occurred more frequently in the non‑COPD group. Multivessel disease (MVD) with or without left main coronary artery (LMCA) involvement and separate LMCA was diagnosed more often in the COPD group. At baseline, the culprit lesion was more often restenosis and in‑stent thrombosis in the COPD group, whereas de‑novo lesion-in the non‑COPD group. The rates of periprocedural mortality and myocardial infarction did not differ between the groups with and without COPD (0.13% vs 0.12%, P = 0.88 and 0.53% vs 0.45%, P = 0.39, respectively). COPD was found to be an independent predictor of restenosis assessed before PCI in patients with a history of PCI (P = 0.006). CONCLUSIONS Patients with COPD diagnosed before PCI are at an increased risk of MVD with or without LMCA involvement and NSTEMI. Restenosis and in‑stent thrombosis occur more often in patients with COPD before PCI.

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Section: Results Characteristics Of Patients With and Without Chronicmentioning

confidence: 99%

Chronic obstructive pulmonary disease affects the angiographic presentation and outcomes of patients with coronary artery disease treated with percutaneous coronary interventions

Januszek¹,

Siudak²,

Dziewierz³

et al. 2017

Polish Archives of Internal Medicine

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“…All four available studies assessing the consistency of measurements of bronchial wall thickness in EBUS and HRCT in patients with obstructive pulmonary diseases have proven that the total thickness of the bronchial wall measured in EBUS did not differ significantly from measurements obtained in HRCT, which is recognized as the reference method. 14 , 15 , 17 , 18 HRCT allows to measure only the total thickness of the bronchial wall without assessing its particular layers. In a study by Soja et al, 17 the comparison of the EBUS and HRCT measurements in COPD patients did not show significant differences, although the total bronchial wall thickness assessed using EBUS was slightly greater than that assessed with HRCT (1.192 ±0.079 mm vs 1.173 ±0.064 mm, p =0.1).…”

Section: Discussionmentioning

confidence: 99%

“… 16 Studies have shown that EBUS is useful in measuring the thicknesses of the bronchial walls and their individual layers in patients with asthma and COPD. 15 , 17 , 18 According to a thorough review of the available literature, EBUS has not been used so far to evaluate the remodeling in patients with ACO.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Airway Remodeling Using Endobronchial Ultrasound in Asthma-COPD Overlap

Górka¹,

Gross‐Sondej²,

Górka³

et al. 2021

JAA

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Purpose The aim of this study was to evaluate the structural changes of the airways using the endobronchial ultrasound (EBUS) in ACO patients compared to severe asthma and COPD patients. Patients and Methods The study included 17 patients with ACO, 17 patients with COPD and 33 patients with severe asthma. Detailed clinical data were obtained from all participants. Basic laboratory tests were performed, including measurement of eosinophil counts in blood and serum immunoglobulin E (IgE) concentrations. All patients underwent spirometry and bronchoscopy with EBUS (a 20‑MHz ultrasound probe) to measure the total thicknesses of the bronchial walls and their particular layers in segmental bronchi of the right lower lobe. EBUS allows to distinguish five layers of the bronchial wall. Layer 1 (L 1 ) and layer 2 (L 2 ) were analyzed separately, while the outer layers (layers 3–5 [L 3–5 ]) that correspond to cartilage were assessed together. Results In patients with ACO the thicknesses of the L 1 and L 2 layers, which are mainly responsible for remodeling, were significantly greater than in patients with COPD and significantly smaller than in patients with severe asthma (median L 1 = 0.17 mm vs 0.16 mm vs 0.18 mm, p <0.001; median L 2 = 0.18 mm vs 0.17 mm vs 0.20 mm, p <0.001, respectively). The thicknesses of the total bronchial walls (L 1 +L 2 +L 3–5 ) and L 3–5 were significantly smaller in ACO and COPD patients compared to asthma patients (median L 1 +L 2 +L 3–5 = 1.2 mm vs 1.14 mm vs 1.31 mm, p <0.001; median L 3–5 = 0.85 mm vs, 0.81 mm vs 0.92 mm, p =0.001, respectively). Conclusion The process of structural changes in the airways assessed by EBUS is more advanced in individuals with ACO compared to patients with COPD, and less pronounced compared to patients with severe asthma. It seems that EBUS may provide useful information about differences in airway remodeling between ACO, COPD and severe asthma.

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“…6 In the last few years, several studies have shown that a new bronchoscopic technique, namely, endobronchial ultrasound (EBUS), may be used for the evaluation of airway remodeling in obstructive lung diseases. [7][8][9] Of note, there is a significant contribution of a research group from Cracow, Poland, to the development of the method and to the promotion of its application in respiratory research.…”

mentioning

confidence: 99%

“…In addition, EBUS seems to be more accurate than HRCT in the assessment of the airway wall, allowing even to discriminate its particular layers. 9,10 Indeed, a very recent study showed that EBUS may be more precise than HRCT in the measurement of BWT. 13 However, it must be emphasized that the evaluation of the features of the airway wall by EBUS is usually limited to a single segmental bronchus.…”

mentioning

confidence: 99%

Seeking for the links between biochemical markers of remodeling and structural changes in chronic obstructive pulmonary disease: where are we?

Krenke¹,

Maskey-Warzęchowska²,

Górska³

2016

Polish Archives of Internal Medicine

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Assessment of remodeling in chronic obstructive pulmonary disease using imaging methods

Cited by 5 publications

References 6 publications

Chronic obstructive pulmonary disease affects the angiographic presentation and outcomes of patients with coronary artery disease treated with percutaneous coronary interventions

Chronic obstructive pulmonary disease affects the angiographic presentation and outcomes of patients with coronary artery disease treated with percutaneous coronary interventions

Assessment of Airway Remodeling Using Endobronchial Ultrasound in Asthma-COPD Overlap

Seeking for the links between biochemical markers of remodeling and structural changes in chronic obstructive pulmonary disease: where are we?

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