Assessment of Regaining Pulp Sensibility in Mature Necrotic Teeth Using a Modified Revascularization Technique with Platelet-rich Fibrin: A Clinical Study

Nageh, Mohamed; Ahmed, Geraldine M.; El-Baz, Alaa A

doi:10.1016/j.joen.2018.06.014

Cited by 40 publications

(64 citation statements)

References 60 publications

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“…The objective of pulp sensitivity tests is to stimulate A-delta nerves in the pulp-dentin complex by applying cold, heat, and an electric test (Pitt Ford and Patel 2004; Abd-Elmeguid and Yu 2009). In this study, 56%, 28%, and 50% of the cases regained sensitivity to cold, hot, and electric tests, respectively, at 12 mo of follow-up The current results coincide with those reported by other authors: 50% (Paryani and Kim 2013) and 60% (Nageh et al 2018) of cases had a positive response to sensitivity tests in mature teeth treated with REPs.…”

Section: Discussionsupporting

confidence: 92%

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

et al. 2020

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A randomized controlled phase I/II clinical trial was designed to evaluate the safety and efficacy of encapsulated human umbilical cord mesenchymal stem cells in a plasma-derived biomaterial for regenerative endodontic procedures (REPs) in mature permanent teeth with apical lesions. The trial included 36 patients with mature incisors, canines, or mandibular premolars showing pulp necrosis and apical periodontitis. Patients were randomly and equally allocated between experimental (REP) or conventional root canal treatment (ENDO) groups. On the first visit, cavity access and mechanical preparation of the root canal were performed. Calcium hydroxide medication was used, and the cavity was sealed. Three weeks later, patients were treated following their assigned protocol of ENDO or REP. Clinical follow-up examinations were performed at 6 and 12 mo. Categorical variables were evaluated by Fisher’s exact test. Quantitative variables were compared using the Mann-Whitney test. The evolution over time of the percentage of perfusion units and the dimensions of lesion and cortical compromise were explored. After the 12-mo follow-up, no adverse events were reported, and the patients showed 100% clinical efficacy in both groups. Interestingly, in the REP group, the perfusion unit percentage measured by laser Doppler flowmetry revealed an increase from 60.6% to 78.1% between baseline and 12-mo follow-up. Sensitivity tests revealed an increase of the positive pulp response in the REP group at 12-mo follow-up (from 6% to 56% on the cold test, from 0% to 28% on the hot test, and from 17% to 50% on the electrical test). We present the first clinical safety and efficacy evidence of the endodontic use of allogenic umbilical cord mesenchymal stem cells encapsulated in a plasma-derived biomaterial. The innovative approach, based on biological principles that promote dentin-pulp regeneration, presents a promising alternative for the treatment of periapical pathology (ClinicalTrials.gov NCT03102879).

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Section: Discussionsupporting

confidence: 92%

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

et al. 2020

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“…Nevertheless, An autologous scaffold loaded with growth factors is most ethical and cost-effective. Also In the field of REP, LPRF has been implemented with promising results in terms of periapical bone healing, further root development [8] and regaining pulp sensibility [9]. The LPRF-clot has a specific anatomy (Fig.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity potential of Portland cement in regenerative endodontic procedures: From clinic to lab

Meschi

Gorp

et al. 2019

Dental Materials

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…43 In our study, electric pulp tester readings where obtained at 3,6,9,12 months follow up periods. [44][45] There was no statistical difference between the two groups in sensibility testing throughout the follow up period. Moreover our results showed early positive sensibility testing at 9,12 months recall, these results could be due to restoring of the pulp chamber space which was filled with revascularized tissue.…”

Section: Discussionmentioning

confidence: 79%

Evaluation of Survival of Mature Second Premolar with Periapical Lesion Following Different Regenerative Treatment Protocols: A Randomized Controlled Trial

Wagih Tarek Ali,

Jealan M. El-Shafei,

Moushira Dahaba

et al. 2021

IJPHRD

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Introduction:The aim of the present study was to compare the survival, periapical healing and regaining sensibility of necrotic mature second premolars with periapical lesion following treatment with two different regenerative protocols, Platelet Rich Plasma(PRP) versus Platelet Rich Fibrin(PRF) pulp regeneration. Both regenerative endodontic procedures were used for regeneration of pulp tissue in the root canal.Methods: Twenty eight patients with mature, single canalled, necrotic, and asymptomatic second premolar with radiographic evidence of periapical lesion were included. At the first visit, the tooth was anesthetized, isolated and an access cavity was performed. Mechanical preparation of root canals was performed using the standardized technique reaching apical canal preparation to K-file size #40-60. Antibiotic paste was injected in canal, and the cavity was temporarily sealed. Two weeks later, regenerative procedures were performed by applying PRP (group 1) and PRF (group 2) in root canal and pulp chamber space. Collagen plug was placed directly over platelet concentrates followed by biodentin. Survival was defined as retention of the tooth in the arch at 12 months recall. Cone beam computed tomography assessments were done through recording of bone healing of periapical lesion and density of pulp chamber space at 12 months recall. The electric pulp test was used to record at 3,6,9 and 12 months follow-up.Results: There was no statistically significant difference in survival of teeth and healing of periapical lesions between the two groups at 12 months recall. Readings of sensibility revealed statistically significant difference (P < .0001) between baseline and the 12-months follow-up,with no statistically significant difference between the two groups.Conclusions: PRP and PRF combined with revascularization protocol were successful treatment modalities for survival of mature necrotic teeth and healing of periapical lesion. Platelet concentrates protocol is successful in regaining sensibility of necrotic teeth.

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Assessment of Regaining Pulp Sensibility in Mature Necrotic Teeth Using a Modified Revascularization Technique with Platelet-rich Fibrin: A Clinical Study

Cited by 40 publications

References 60 publications

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

Bioactivity potential of Portland cement in regenerative endodontic procedures: From clinic to lab

Evaluation of Survival of Mature Second Premolar with Periapical Lesion Following Different Regenerative Treatment Protocols: A Randomized Controlled Trial

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