Assessment of Red Cell Distribution Width, Platelet/lymphocyte Ratio, Systemic Immune-inflammation Index, and Neutrophil/lymphocyte Ratio Values in Patients with Central Retinal Artery Occlusion

Elbeyli, Ahmet; Kurtul, Bengi Ece; Özcan, Deniz Özarslan; Özcan, Sait Coşkun; Doğan, Emine

doi:10.1080/09273948.2021.1976219

Cited by 9 publications

(11 citation statements)

References 24 publications

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“…However, it was difficult to discriminate MHR values between the RAO and RVO groups. Although some previous studies reported that RDW and MPV might be the biomarkers of RVO and RAO [ 34 , 43 ], we did not find any significant difference among RAO, RVO and control groups. We speculated that the patients’ race, exclusion criterion and sample size might be responsible for the various results of different studies.…”

Section: Discussioncontrasting

confidence: 99%

“…According to Sonmez et al [ 13 ], lymphocyte counts can be used as a measure for general bad health and physiological stress. In the present study, we discovered that lymphocyte levels in the RAO and RVO groups were significantly lower than those in the control group, which was consistent with earlier research [ 19 , 22 , 24 , 26 , 43 ]. In this study, lymphocyte levels in the RAO group were likewise considerably lower than those in the RVO group.…”

Section: Discussionsupporting

confidence: 93%

“…Prior researches have looked at the effects of NLR and PLR on predicting RAO or RVO [ 19 – 26 , 43 , 49 , 50 ]. In some investigations, NLR has already been shown to be a unique marker for predicting RAO [ 24 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin

Zhang

et al. 2022

PLoS ONE

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Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Methods This retrospective study assessed 41 RAO, 50 RVO and 50 control (age and gender matched senile cataract) participants. The NLR, PLR and MHR parameters of patients’ peripheral blood were analyzed. A receiver operating characteristics (ROC) curve analysis and the best cutoff value were used to specify the predictive value of NLR, PLR and MHR in RAO and RVO. Results The NLR, PLR and MHR were significantly higher in RAO group compared to the control group (p<0.001, p<0.001 and p = 0.008; respectively). The NLR, PLR and MHR were also significantly higher in the RVO group compared to the control group (p<0.001, p = 0.001 and p = 0.012, respectively). The NLR and PLR were significantly higher in the RAO group compared to the RVO group (p<0.001 and p = 0.022, respectively). The optimal cut-off value of NLR to predict RAO was >2.99, with 90.2% sensitivity and 100% specificity. The PLR to predict RAO was > 145.52, with 75.6% sensitivity and 80.0% specificity. Conclusion Higher NLR, PLR and MHR are related to the occurrence of RAO and RVO. NLR and PLR are more prominent in RAO compared to RVO.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin

Zhang

et al. 2022

PLoS ONE

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“…After receiving antigen information, plasma cells produce antibodies while memory cells rapidly evoke an immune response in subsequent infections. [40,91,92] T cells can express antigenspecific receptors: CD4+ T cells can accept MHC Class II antigens presented by antigen-presenting cells such as B cells and dendritic cells for immune regulation while CD8+ T cells can accept MHC Class I antigens and produce cytotoxicity. [93,94] Though NK cells lack antigen receptors, they can produce IFNγ in early infection and directly kill infected cells by releasing cytotoxic particles.…”

Section: Lymphocyte-based Ddss For Treating Cancersmentioning

confidence: 99%

Living Leukocyte‐Based Drug Delivery Systems

et al. 2023

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Leukocytes play a vital role in immune responses, including defending against invasive pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the immune system is activated in vivo, leukocytes accomplish a series of orderly and complex regulatory processes. While cancer and inflammation‐related diseases like sepsis are critical medical difficulties plaguing humankind around the world, leukocytes have been shown to largely gather at the focal site, and significantly contribute to inflammation and cancer progression. Therefore, the living leukocyte‐based drug delivery systems have attracted considerable attention in recent years due to the innate and specific targeting effect, low immunogenicity, improved therapeutic efficacy, and low reverse effect. In this review, the recent advances in the development of living leukocyte‐based drug delivery systems including macrophages, neutrophils, and lymphocytes as promising treatment strategies for cancer and inflammation‐related diseases are introduced. The advantages, current challenges, and limitations of these delivery systems are also discussed, as well as perspectives on the future development of precision and targeted therapy in the clinics are provided. Collectively, it is expected that such kind of living cell‐based drug delivery system is promising to improve or even revolutionize the treatments of cancers and inflammation‐related diseases in the clinics.

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“…Prior researches have looked at the effects of NLR and PLR on predicting RAO or RVO [19][20][21][22][23][24][25][26]43,49,50]. In some investigations, NLR has already been shown to be a unique marker for predicting RAO [24,26].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Red Cell Distribution Width, Platelet/lymphocyte Ratio, Systemic Immune-inflammation Index, and Neutrophil/lymphocyte Ratio Values in Patients with Central Retinal Artery Occlusion

Cited by 9 publications

References 24 publications

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Living Leukocyte‐Based Drug Delivery Systems

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