Assessment of recombinant beak and feather disease virus capsid protein as a vaccine for psittacine beak and feather disease

Bonne, Nicolai; Shearer, Patrick; Sharp, Margaret; Clark, P.; Raidal, Shane R.

doi:10.1099/vir.0.006932-0

Cited by 41 publications

(25 citation statements)

References 23 publications

(27 reference statements)

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“…The hypothesis that a subunit vaccine against PiCV could be effective in preventing YPDS is based on studies where similar vaccines have been used for controlling porcine circovirus infections in pigs (Zhang et al 2015b;Zhu et al 2016;Li et al 2016). Attempts have also been made to immunize parrots with the recombinant capsid protein of the psittacine circovirus, but the efficacy of the vaccine was not confirmed (Bonne et al 2009). In view of the above, the only available solution for controlling the spread of PiCV infections involves the prevention of common viral and bacterial diseases in pigeons, the use of immunomodulators during vaccination and weaning, elimination of stress, and selection of parent stock based on the results of serological and molecular tests (Duchatel & Szeleszczuk 2011;Stenzel et al 2011;Stenzel et al 2016).…”

Section: Diagnosis Treatment and Preventionmentioning

confidence: 99%

The epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons – current knowledge

Stenzel

Koncicki

2017

Veterinary Quarterly

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The first cases of circovirus infections in pigeons were documented less than 25 years ago. Since then, circovirus infections have been reported on nearly all continents. The specificity of pigeon breeding defies biosecurity principles, which could be the reason for the high prevalence of PiCV infections. PiCV infections in pigeons lead to atrophy of immune system organs and lymphocyte apoptosis. Infected birds could be more susceptible to infections of the respiratory and digestive tract. PiCV has been associated with the young pigeon disease syndrome (YPDS). PiCVs are characterized by high levels of genetic diversity due to frequent point mutations, recombination processes in the PiCV genome and positive selection. Genetic recombinations and positive selection play the key role in the evolution of PiCV. A protocol for culturing PiCV under laboratory conditions has not yet been developed, and traditional vaccines against the infection are not available. Recombinant capsid proteins for detecting anti-PiCV antibodies have been obtained, and these antigens can be used in the production of diagnostic tests and subunit vaccines against PiCV infections. However, YPDS has complex etiology, and it remains unknown whether immunization against PiCV alone will contribute to effective control of YPDS.

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Section: Diagnosis Treatment and Preventionmentioning

confidence: 99%

The epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons – current knowledge

Stenzel

Koncicki

2017

Veterinary Quarterly

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“…PBFDV PCR screening samples Blood and feather samples were tested using the replicase-associated PBFDV gene PCR primers. Lane 1-20 (upper) screened blood samples, Lane [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] (lower) screened feather samples. Lane 4 (upper) and lane 1 (lower) PBFDV control positive.…”

Section: Pcr Screening Of Avian Extracts For Pbfdv Dnamentioning

confidence: 99%

“…However, to overcome this problem, PCR have been developed for identification and classification of several pathogens including PBFDV. These molecular techniques offer higher sensitivity and specificity compared to serological test [3]. In addition, PCR based diagnosis can be used for identification of both clinically suspect, and apparently health carrier cases of PBFD [4].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Psittacine Beak and Feather Disease Virus in Saudi Arabia Using Molecular Technique

Hakami¹

2017

IJAWB

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Psittacine Beak and Feather Disease (PBFD) is a contagious, fatal viral disease that affects the beak, feathers, and immune system of wild and captive old and New World Psittacine. PBFD is characterized by feather abnormalities, beak and claw deformities and eventually dying as a result of immunosuppressant. The disease is caused by member of the genus circovirus in the family Circoviridae. The disease diagnosed by clinical signs and laboratory detections. The serological diagnosis by haemagglutination (HA) and haemagglutination inhibition (HI) is subjective but molecular technique using Polymerase chain reaction (PCR) is the most reliable means for confirming the presence of the PBFDV ambience DNA genome in whole blood or tissue samples. Many birds were presented to the veterinary clinic with clinical signs of PBFD. No reports document the presence of PBFDV in KSA to date. Therefore, the objective of this work was to investigate the presence of PBFDV in KSA using PCR. Total 175 samples (blood and feathers) from clinically-suspect, and apparently-health birds from 10 different psittacine species were collected, DNA was extracted and conventional PCR was performed. The viral DNA was identified in six samples (6/175) four Grey parrots (Psittacus erithacus), and two ring necks (Psittacula eupatria eupatria). PBFDV was identified for the first time in the Kingdom of Saudi Arabia (KSA). During this investigation, we developed a technique for faster and simpler processing of multiple feather samples. The isolated PBFDV could be characterize and use as positive control for further research purpose. We recommend that the Rep gene feather-based PCR technique be established as a routine diagnostic tool in quarantine facilities across the country.

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“…The baculovirus-expressed recombinant BFDV capsid protein was recently reported to be immunogenic and might be a suitable candidate vaccine to prevent PBFD in psittacine birds [7]. However, an optimal vaccination regime needs to be determined to protect against PBFD.…”

Section: ]mentioning

confidence: 99%

A Review of DNA Viral Infections in Psittacine Birds

et al. 2010

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ABSTRACT. To date, several DNA viral infections have been reported in psittacine birds. Psittacine beak and feather disease (PBFD) is characterized by symmetric feather dystrophy and loss and development of beak deformities. PBFD is caused by beak and feather virus, which belongs to the Circoviridae, and is the most important infection in psittacine birds worldwide. Avian polyomavirus infection causes acute death, abdominal distention, and feather abnormalities. Pacheco's disease (PD), which is caused by psittacid herpesvirus type 1, is an acute lethal disease without a prodrome. Psittacine adenovirus infections are described as having a clinical progression similar to PD. The clinical changes in psittacine poxvirus-infected birds include serious ocular discharge, rhinitis, and conjunctivitis, followed by the appearance of ulcerations on the medial canthi of the eyes. Internal papillomatosis of parrots (IPP) is a tumor disease characterized by progressive development of papillomas in the oral and cloacal mucosa. IPP has been suggested to caused by papillomavirus or herpesvirus. However, information about these diseases is limited. Here we review the etiology, clinical features, pathology, epidemiology, and diagnosis of these DNA viruses.KEY WORDS: DNA virus, psittacine bird, review.

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Assessment of recombinant beak and feather disease virus capsid protein as a vaccine for psittacine beak and feather disease

Cited by 41 publications

References 23 publications

The epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons – current knowledge

The epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons – current knowledge

Isolation and Characterization of Psittacine Beak and Feather Disease Virus in Saudi Arabia Using Molecular Technique

A Review of DNA Viral Infections in Psittacine Birds

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