Assessment of quality of life in patients surgically treated for penile cancer: Impact of aggressiveness in surgery

Sosnowski, Roman; Wolski, Jan; Kulpa, Marta; Ziętalewicz, Urszula; Kosowicz, Mariola; Kalinowski, Tomasz; Demkow, Tomasz

doi:10.1016/j.ejon.2017.08.011

Cited by 17 publications

(25 citation statements)

References 28 publications

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“…A correlation between the invasiveness of treatment and QoL has been reported. 8,9 Some studies do, however, report contrasting findings of unaltered post-treatment QoL. 21 In this investigation, we found no correlation between the extent of disease and the post-treatment QoL, for reasons that can only be speculated: Our series had a high proportion of cases with invasive disease who had undergone radical surgical treatment.…”

Section: Article In Pressmentioning

confidence: 48%

Health-Related Quality of Life, Self-esteem and Sexual Functioning Among Patients Operated for Penile Cancer – A Cross-sectional Study

Harju

Pakarainen

Vasarainen

et al. 2021

The Journal of Sexual Medicine

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Background: Penile cancer surgery affects physical, psychological, and sexual well-being, but the patient-and treatment-related factors predisposing to worse health-related quality of life (HRQoL) have not been well characterized. Aim: We report treatment-related HRQoL changes among penile cancer survivors compared to the general population and the specific deficits that have the most profound effect, and we identify patient-related factors that predispose to a worse perceived HRQoL. Methods: Patients (n = 107) who underwent operations for invasive penile cancer in two Finnish university hospitals from 2009 to 2019 were sent the Patient Reported Outcomes (PROs) questionnaire designed to measure HRQoL, self-esteem, overall sexual functioning, erections, and change in sexual function. We collected clinical information and socio-demographic characteristics, including age, partner status, children, vocational education, and employment status. Associations between patient-and treatment-related factors and HRQoL were analyzed using descriptive statistics and non-parametric tests. Linear regression models were used to compare the HRQoL differences between patients with penile cancer and the age-standardized average for the Finnish population. Outcomes: A generic measure of HRQoL (15D), the Rosenberg Self-Esteem Scale, Overall Sexual Functioning Questionnaire, the Erection Hardness Score, and self-reported change in sexual functioning. Results: Low scores in overall sexual functioning, erectile function, and changes in sexual functioning were associated with a lower HRQoL. An association was found between HRQoL and age, educational level, employment status, and place of residence. The HRQoL had a negative correlation with age. Patients with a high educational level, who were employed, or who lived in urban areas reported higher HRQoL. The mean HRQoL of penile cancer survivors was significantly lower than the age-standardized average HRQoL of the Finnish population. Clinical Implications: Enhanced support and counseling is needed among penile cancer patients to improve the HRQoL during survivorship. Strengths & Limitations: A nationwide sample with detailed information allowed comparisons of HRQoL between penile cancer patients and the general population. Due to cross-sectional nature of the study, the time between the surgery and the study intervention was heterogeneous, and this may have affected the results. Conclusion: Penile cancer patients exhibit significant physical and psychological dysfunction, and the lack of sexual activity in general is what most compromises the QoL of penile cancer survivors. Harju E, Pakarainen T, Vasarainen H, et al. Health-Related Quality of Life, Self-esteem and Sexual Functioning Among Patients Operated for Penile Cancer − A Cross-sectional Study. J Sex Med 2021;XX:XXX−XXX.

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Section: Article In Pressmentioning

confidence: 48%

Health-Related Quality of Life, Self-esteem and Sexual Functioning Among Patients Operated for Penile Cancer – A Cross-sectional Study

Harju

Pakarainen

Vasarainen

et al. 2021

The Journal of Sexual Medicine

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“…The functional outcomes and quality of life post total penectomy are difficult to accurately describe here given the relative paucity of data specific to it. Several studies have looked to assess function post-partial penectomy, however some small studies involving optional patient questionnaires have indicated that as expected there are significant effects on a patient's sex life and quality of life (16)(17)(18). This is in keeping with data from partial penectomy patient's, however it appears that there are not the same negative effects on partner relations or one's own assessment of masculinity with partial penectomy as compared to total penectomy (19).…”

Section: Discussionmentioning

confidence: 80%

The role of penectomy in penile cancer—evolving paradigms

et al. 2020

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Penile cancer is a rare cancer, with the majority treated with penile preserving methods.There remains a role for partial and totally penectomy for advanced and more proximal penile cancers.Significant functional and psychological morbidity can ensue for patients undergoing surgical management.Recent studies and guidelines are changing the way Urologists approach surgical management of penile malignancies. Reductions in safe surgical margin recommendations from 2 cm to 3-5 mm provide surgeons with the ability to perform penile preserving techniques to maximise patient functionality. These guidelines are reflected by recent studies showing that smaller surgical margins; although heralding higher rates of local recurrence, have no detriment on cancer specific or overall survival rate. Although oncological clearance remains the primary outcome for surgical management of penile cancer, the ability to perform radical salvage surgery at a later date means patients are more likely to experience a longer period of functionality without sacrificing oncologic outcomes. The importance of patient education on regular self-examination as well as clinic follow up are key in identifying local recurrence and planning salvage surgery if needed to maintain oncologic control. Ongoing studies into the functional and psychological outcomes of patients undergoing partial penectomy show encouraging results however further studies are needed to elucidate long-term outcomes. The evolving paradigm of surgical management in penile malignancy is shifting to favour organ preserving techniques in order to maximise functional, psychological and aesthetic outcomes without compromising patients' oncologic outcomes-however a role still exists for radical surgery in advanced penile malignancy.

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“…De acordo com à multiculturalidade, os artigos revisados entram em consonância no quesito estética, afirmando que não há grandes insatisfações após a penectomia parcial, uma vez que tal procedimentos é amplamente disseminado por ser padrão-ouro no tratamento do câncer de pênis (DJAJADININGRAT et al, 2014;DO COUTO et al, 2014;HAKANSSON et al, 2015;GAO et al, 2016;AUDENET;SFAKIANOS, 2017;SOSNOWSKI et al, 2017;COELHO et al, 2018).…”

Section: Resultados E Discussão  Aspectos Epidemiológicos E Fatores unclassified

“…O abandono do tratamento é um evento comum nesse tipo de câncer, sobretudo pelo fato de o tratamento de escolha ser a penectomia. O paciente penectomizado, no âmbito psicológico, perde a sua referência de masculinidade e, comumente, não retorna ao serviço de saúde para dar seguimento ao tratamento e controle da doença (SOSNOWSKI et al, 2017;COELHO et al, 2018).…”

Section: Resultados E Discussão  Aspectos Epidemiológicos E Fatores unclassified

Câncer de pênis: aspectos epidemiológicos, psicológicos e fatores de risco

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Fernandes

Pinheiro

et al. 2019

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Assessment of quality of life in patients surgically treated for penile cancer: Impact of aggressiveness in surgery

Cited by 17 publications

References 28 publications

Health-Related Quality of Life, Self-esteem and Sexual Functioning Among Patients Operated for Penile Cancer – A Cross-sectional Study

Health-Related Quality of Life, Self-esteem and Sexual Functioning Among Patients Operated for Penile Cancer – A Cross-sectional Study

The role of penectomy in penile cancer—evolving paradigms

Câncer de pênis: aspectos epidemiológicos, psicológicos e fatores de risco

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