Assessment of pulmonary function by impulse oscillometry and spirometry in children with type 1 diabetes mellitus

Anık, Ayşe; Uysal, Pınar

doi:10.1002/ppul.25019

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…In line with this, the presence of diabetes has been shown to be associated with a restrictive lung function pattern in a meta-analysis [ 42 ]. Furthermore, subclinical impairment of lung function was seen in children with type 1 diabetes mellitus and was associated with disease duration and the degree of metabolic control [ 43 ]. This might not surprise as the large vascular network and high collagen and elastin composition of the pulmonary system, is prone to microvascular damage and nonenzymatic glycation in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study

et al. 2022

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Background Whether restricted spirometry, i.e. low Forced Vital Capacity (FVC), predicts chronic cardiometabolic disease is not definitely known. In this international population-based study, we assessed the relationship between restricted spirometry and cardiometabolic comorbidities. Methods A total of 23,623 subjects (47.5% males, 19.0% current smokers, age: 55.1 ± 10.8 years) from five continents (33 sites in 29 countries) participating in the Burden of Obstructive Lung Disease (BOLD) study were included. Restricted spirometry was defined as post-bronchodilator FVC < 5th percentile of reference values. Self-reports of physician-diagnosed cardiovascular disease (CVD; heart disease or stroke), hypertension, and diabetes were obtained through questionnaires. Results Overall 31.7% of participants had restricted spirometry. However, prevalence of restricted spirometry varied approximately ten-fold, and was lowest (8.5%) in Vancouver (Canada) and highest in Sri Lanka (81.3%). Crude odds ratios for the association with restricted spirometry were 1.60 (95% CI 1.37–1.86) for CVD, 1.53 (95% CI 1.40–1.66) for hypertension, and 1.98 (95% CI 1.71–2.29) for diabetes. After adjustment for age, sex, education, Body Mass Index (BMI) and smoking, the odds ratios were 1.54 (95% CI 1.33–1.79) for CVD, 1.50 (95% CI 1.39–1.63) for hypertension, and 1.86 (95% CI 1.59–2.17) for diabetes. Conclusion In this population-based, international, multi-site study, restricted spirometry associates with cardiometabolic diseases. The magnitude of these associations appears unattenuated when cardiometabolic risk factors are taken into account.

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Section: Discussionmentioning

confidence: 99%

Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study

et al. 2022

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“…Influenza affects the metabolism of human neutrophil calcium, which might be an explanation for this strong association with hospitalization. Additionally, there is mounting evidence showing that the lung is a target organ for diabetic injury from the beginning of the disease in patients of pediatric age [ 11 , 12 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

Mylonakis

Mylona

Kalligeros

et al. 2022

IJERPH

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Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42–15.32 and OR: 6.35, 95% CI: 3.60–11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions.

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“…In line with this, the presence of diabetes has been shown to adversely affect respiratory function, resulting in a restrictive lung function pattern 247 . Furthermore, subclinical impairment of lung function was seen in children with type 1 diabetes mellitus and was associated with disease duration and the degree of metabolic control 248 . This might not surprise as the large vascular network and high collagen and elastin composition of the pulmonary system is prone to microvascular damage and non‐enzymatic glycation in diabetes.…”

Section: From Lung Function To Multimorbidity: Trajectories In Copdmentioning

confidence: 99%

Contemporary perspectives in COPD: Patient burden, the role of gender and trajectories of multimorbidity

et al. 2021

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An individual's experience of COPD is determined by many factors in addition to the pathological features of chronic bronchitis and emphysema and the symptoms that derive directly from them. Multimorbidity is the norm rather than the exception, so most people with COPD are living with a range of other medical problems which can decrease overall quality of life. COPD is caused by the inhalation of noxious particles or gases, in particular tobacco smoke, but also by early life disadvantage impairing lung development and by occupations where inhaled exposures are common (e.g. industrial, farming and cleaning work). Wealthy people are therefore relatively protected from developing COPD and people who do develop the condition may have reduced resources to cope. COPD is also no longer a condition that predominantly affects men. The prevalence of COPD among women has equalled that of men since 2008 in many high‐income countries, due to increased exposure to tobacco, and in low‐income countries due to biomass fuels. COPD is one of the leading causes of death in women in the USA, and death rates attributed to COPD in women in some countries are predicted to overtake those of men in the next decade. Many factors contribute to this phenomenon, but in addition to socioeconomic and occupational factors, there is increasing evidence of a higher susceptibility of females to smoking and pollutants. Quality of life is also more significantly impaired in women. Although most medications (bronchodilators and inhaled corticosteroids) used to treat COPD demonstrate similar trends for exacerbation prevention and lung function improvement in men and women, this is an understudied area and clinical trials frequently have a preponderance of males. A better understanding of gender‐based predictors of efficacy of all therapeutic interventions is crucial for comprehensive patient care. There is an urgent need to recognize the increasing burden of COPD in women and to facilitate global improvements in disease prevention and management in this specific population. Many individuals with COPD follow a trajectory of both lung function decline and also multimorbidity. Unfavourable lung function trajectories throughout life have implications for later development of other chronic diseases. An enhanced understanding of the temporal associations underlying the development of coexisting diseases is a crucial first step in unravelling potential common disease pathways. Lessons can be learned from exploring disease trajectories of other NCD as well as multimorbidity development. Further research will be essential to explain how early life risk factors commonly influence trajectories of COPD and other diseases, how different diseases develop in relation to each other in a temporal way and how this ultimately leads to different multimorbidity patterns in COPD. This review integrates new knowledge and ideas pertaining to three broad themes (i) the overall burden of disease in COPD, (ii) an unappreciated high burden in women and (iii) the contrast...

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Assessment of pulmonary function by impulse oscillometry and spirometry in children with type 1 diabetes mellitus

Cited by 11 publications

References 34 publications

Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study

Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study

How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

Contemporary perspectives in COPD: Patient burden, the role of gender and trajectories of multimorbidity

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