Assessment of Prognostic Value of "Neutrophil to Lymphocyte Ratio" and "Prognostic Nutritional Index" as a Sytemic Inflammatory Marker in Non-small Cell Lung Cancer

Köş, Fahriye Tuğba; Hocazade, Cemil; Köş, Mehmet; Uncu, Doğan; Karakaş, Esra; Doğan, Mutlu; Uncu, Hasan; Özdemir, Nuriye; Zengi̇n, Nurullah

doi:10.7314/apjcp.2015.16.9.3997

Cited by 48 publications

(40 citation statements)

References 22 publications

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“…Albeit different PNI cut-off values have been reported previously for NSCLC patients, again these studies were restrained by heterogeneous patient attributes which hindered the ability to reveal the precise relationship between the specified PNI cut-offs and survival outcomes. 34,35 For instance, Kos et al reported that the mean OS for patients with PNI < 49.5 and ≥ 49.5 were 7 and 33 months in a sum of 138 NSCLC patients, respectively. 34 Nonetheless, patients were categorized according to the median cut-off value rather than on a more reliable statistical tool, such as the ROC curve analysis.…”

Section: Discussionmentioning

confidence: 99%

“…34,35 For instance, Kos et al reported that the mean OS for patients with PNI < 49.5 and ≥ 49.5 were 7 and 33 months in a sum of 138 NSCLC patients, respectively. 34 Nonetheless, patients were categorized according to the median cut-off value rather than on a more reliable statistical tool, such as the ROC curve analysis. Moreover, the study population included patients with heterogeneous disease stages ranging from stage I to IV, and only 15% of them received CRT as the primary treatment.…”

Section: Discussionmentioning

confidence: 99%

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<p>Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy</p>

Özdemir

Topkan

Mertsoylu

et al. 2020

CMAR

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Purpose: To investigate the prognostic utility of the prognostic nutritional index (PNI) in stage IIIB non-small-cell lung carcinoma (NSCLC) patients undergoing concurrent chemoradiotherapy (CRT). Methods: A total of 358 stage IIIB NSCLC patients who received a total dose of 60-66 Gy (2 Gy/fraction) radiotherapy and ≥1 cycle(s) of platinum-based chemotherapy were analyzed. The receiver operating curve analysis was utilized to identify the optimal PNI cutoff value demonstrating a significant connection with the overall survival (OS), locoregional progression-free survival (LRPFS), and progression-free survival (PFS). Results: At a median follow-up time of 22.5 months (range: 2.4-123.5), 30.2% and 14% of the patients were still alive and free of disease progression, respectively.The median OS, LRPFS, and PFS were 25.2 [95% confidence interval (CI): 36.3-46.6 months], 15.4 (95% CI: 26.6-35.3 months), and 10.7 (95% CI: 36.8-69.9 months), individually, for the whole study accomplice. The ROC analysis revealed an optimum rounded cutoff that associated meaningfully with each of the OS [area under the curve (AUC): 84.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

<p>Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy</p>

Özdemir

Topkan

Mertsoylu

et al. 2020

CMAR

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“…Additionally, to evaluate nutritional status, more complex indices, such as the prognostic nutritional index (PNI), have been developed and widely used 9–13 . The PNI is a combined nutritional-inflammatory score based on serum albumin levels and the lymphocyte count that reflects the immunological nutritional condition and that measures the risk of several types of cancer in patients 14 . This index is convenient to obtain since only simple blood biomarkers are required.…”

Section: Introductionmentioning

confidence: 99%

Prognostic nutritional index predicts clinical outcome in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Chen

et al. 2017

Sci Rep

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We aimed to investigate whether the prognostic nutritional index (PNI), a combined nutritional-inflammatory score based on serum albumin levels and lymphocyte count, was associated with mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). From September 2011 to November 2014, 309 consecutive patients with STEMI undergoing pPCI were prospectively enrolled. Patients with a combined score of albumin (g/L) + 5 × total lymphocyte count × 109/L ≥ 45 or <45 were assigned a PNI score of 0 or 1, respectively. Of the 309 STEMI patients, 24 (7.74%) died in the hospital, and 15 (4.83%) died during long-term follow-up (median follow-up time, 19.5 [3–36] months). Compared to patients with a PNI of 0, patients with a PNI of 1 had significantly higher in-hospital (14.2% vs. 3.7%; P < 0.001) and long-term follow-up (21.7% vs. 6.9%, P < 0.001) mortality rates. PNI (1/0, HR, 2.414; 95% CI, 1.016 to 5.736; P = 0.046) was a significant independent predictor of mortality in patients with STEMI undergoing pPCI. Moreover, cumulative survival was significantly lower for patients with a PNI of 1 compared to patients with a PNI of 0 (78.3% vs. 93.1%, log-rank P < 0.001). PNI appears useful for the risk stratification of STEMI patients undergoing pPCI.

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“…As the conceptual tumor develops over last decade, evading immune destruction has become a cancer progress hallmark [6]. Systemic inflammatory response plays an important role in cancer development or progression but different inflammation-based indices account for different type of cancer [8, 9]. Theoretically, inflammatory status should convey valuable information of lung cancer development or progression but unfortunately most specific inflammatory factors are not accessible before surgery and some are only available as research tools.…”

Section: Introductionmentioning

confidence: 99%

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

et al. 2016

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BackgroundThe aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection.MethodsIn this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of PLR and NLR with OS and RFS.ResultsA total of 174 NSCLC patients were studied. The results indicated that both high PLR (>148.6) and NLR (>2.9) were related to a high rate of postoperative pulmonary complications significantly (49.3%vs.29.1%, P = 0.007; 50.7% vs. 28.6%, P = 0.003). Moreover, NSCLC patients with a high PLR level (> 148.6) was significantly associated with a lower one-year OS (90.3% vs. 77.5%, P = 0.034).ConclusionsPreoperative PLR and NLR were good prognostic factors for postoperative pulmonary complications and OS in NSCLC patients undergoing radical lung cancer surgery. Thus, blood PLR and NLR would be helpful as a prognostic tool before radical lung cancer surgery.

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Assessment of Prognostic Value of "Neutrophil to Lymphocyte Ratio" and "Prognostic Nutritional Index" as a Sytemic Inflammatory Marker in Non-small Cell Lung Cancer

Cited by 48 publications

References 22 publications

<p>Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy</p>

<p>Low Prognostic Nutritional Index Predicts Poor Clinical Outcomes in Patients with Stage IIIB Non-small-cell Lung Carcinoma Undergoing Chemoradiotherapy</p>

Prognostic nutritional index predicts clinical outcome in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

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