Assessment of profilin as an allergen for latex‐sensitized patients

Nieto, Antonio; Mazón, Ángel; Boquete, M.; Carballada, F.; Asturias, Juan A.; Martı́nez, Jorge; Martı́nez, Alberto

doi:10.1034/j.1398-9995.2002.23530.x

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…Nieto et al [37] reported 42% of sensitization to natural and recombinant Hev b 8 as assessed by EAST (6/17 spina bifida patients and 7/14 other latex-allergic patients, 9 of whom were healthcare workers). Rihs et al [38] reported lower prevalences, with 12% of spina bifida patients and 20% of healthcare workers presenting IgE antibodies to rHev b 8 on ImmunoCAP and immunoblot.…”

Section: Profilin: Prevalence Of Sensitizationmentioning

confidence: 99%

Profilins: Mimickers of Allergy or Relevant Allergens?

Santos

Ree

2011

Int Arch Allergy Immunol

139

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Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems to arise from pollen sensitization with later development of cross-reactive IgE antibodies against plant food (and possibly latex) profilins. The role of profilin in inducing allergic symptoms needs to be evaluated and raises important issues in allergy diagnosis due to cross-reactivity. IgE cross-reactivity among profilins is associated with multiple pollen sensitization and with various pollen-food syndromes. In respiratory allergy, sensitization to pollen to which the patient has virtually no environmental exposure has been identified as a manifestation of profilin sensitization. As a food allergen, profilin usually elicits mild reactions, such as oral allergy syndrome, is not modified by processing and is especially important in allergy to some fruits, such as melon, watermelon, banana, tomato, citrus fruit and persimmon. Purified natural and recombinant profilins for in vitro and in vivo allergy tests are helpful in the diagnostic work-up. Herein we review the current state of knowledge about the allergen profilin and its implications in the diagnosis and treatment of allergic diseases. We conclude that, although its role in triggering allergic symptoms is still controversial, profilin is undoubtedly a relevant allergen. As a pan-allergen, profilin is associated with multiple pollen sensitization and pollen-food-latex syndromes that the allergist has to be aware of in order to accomplish an accurate diagnosis and successful treatment of allergic diseases.

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Section: Profilin: Prevalence Of Sensitizationmentioning

confidence: 99%

Profilins: Mimickers of Allergy or Relevant Allergens?

Santos

Ree

2011

Int Arch Allergy Immunol

139

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“…The most likely explanation for these false-positive results should probably be sought in terms of stimulation concentrations. This phenomenon has already been described for other allergens such as Hevea latex [43,][44]. Moreover, it seems justified to state that sensitization to profilin could also account for the false-positive sIgE cannabis results observed in 1 out of 3 plant food-allergic CSA - patients.…”

Section: Discussionmentioning

confidence: 87%

New Food Allergies in a European Non-Mediterranean Region: Is <b><i>Cannabis sativa</i></b> to Blame?

Ebo

Swerts

Sabato

et al. 2013

Int Arch Allergy Immunol

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Background: Allergy to fruit and vegetables exhibit geographic variation regarding the severity of symptoms and depending on the sensitization profile of the patient. These sensitization profiles and routes remain incompletely understood. Cannabis is a very popular drug and derived from Cannabis sativa, a plant containing lipid transfer proteins (LTP) also known as important allergens in plant and fruit allergies. In this study we sought to elucidate a potential connection between C. sativa allergy and plant food allergies. Methods: A case-control study involving 21 patients consulting for plant food allergies. Twelve patients were cannabis allergic and 9 had a pollen or latex allergy without cannabis allergy. Testing for cannabis IgE implied measurement of specific IgE, skin testing and basophil activation tests. Allergen component analysis was performed with a microarray technique. Results: Plant food allergy in patients with documented cannabis allergy had more severe reactions than patients without cannabis allergy and frequently implied fruits and vegetables that are not observed in a (birch) pollen-related food syndrome. With the exception of 1 patient with cannabis allergy, all were sensitized to nonspecific (ns)-LTP. Conclusion: Our data suggest that illicit cannabis abuse can result in cannabis allergy with sensitization to ns-LTP. This sensitization might result in various plant-food allergies. Additional collaborative studies in different geographical areas are needed to further elucidate on this hypothesis.

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“…Nevertheless, clinical relevance of IgE binding to profilin has to be distinguished from cross‐reactive IgE binding without evoking allergic symptoms. Profilin as a relevant allergen has been described in recent studies for patients sensitized to latex, banana, pineapple, melon, hazelnut, celery, carrot, and peach [21, 26–32], and bell pepper was reported to cause clinical food allergy supporting possible clinical relevance of anti‐profilin IgE in selected cases [33].…”

Section: Discussionmentioning

confidence: 99%