Assessment of prevalence and pathological response to orthostatic provocation in patients with multiple sclerosis

Adamec, Ivan; Bach, Ivo; Barušić, Anabella Karla; Mišmaš, Antonija; Habek, Mario

doi:10.1016/j.jns.2012.10.006

Cited by 25 publications

(21 citation statements)

References 21 publications

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“…Despite this, POTS has rarely been reported in MS [2,3] One series described 9 MS patients with POTS, 2 patients developed MS after the diagnosis of POTS, and 7 patients developed POTS sometime after the diagnosis of MS [3]. Authors of this study did not find any correlation between MS symptoms or relapses with POTS.…”

Section: Discussioncontrasting

confidence: 52%

“…Authors of this study did not find any correlation between MS symptoms or relapses with POTS. On the other hand we have recently reported that POTS frequently occurs MS and showed that it is associated with an MS relapse [2].…”

Section: Discussionmentioning

confidence: 96%

“…Pathological response to orthostatic provocation is frequent in MS, occurring in up to 63% of patients [2]. Despite this, POTS has rarely been reported in MS [2,3] One series described 9 MS patients with POTS, 2 patients developed MS after the diagnosis of POTS, and 7 patients developed POTS sometime after the diagnosis of MS [3].…”

Section: Discussionmentioning

confidence: 99%

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Autonomic dysfunction in multiple sclerosis presenting with postural orthostatic tachycardia

2012

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 96%

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Autonomic dysfunction in multiple sclerosis presenting with postural orthostatic tachycardia

2012

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“…1) or postural orthostatic tachycardia syndrome (POTS) (Fig. 2) [11]. OH represents a significant and sustained decrease of blood pressure upon standing [12].…”

Section: Cardiovascular Dysfunctionmentioning

confidence: 99%

Autonomic dysfunction in multiple sclerosis

Adamec

Habek

2013

Clinical Neurology and Neurosurgery

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“…1 The autonomic nervous system dysfunction (ANSD) is commonly seen in patients with MS and is characterized by bladder and gastrointestinal disturbances, sexual dysfunction, abnormalities in cardiovascular function and sudomotor disorders. [1][2][3][4][5][6][7] These symptoms may have a significant impact in patients' quality of life and should be explored as part of the routine evaluation. [1][2][3][4][5]8 Neurological disability assessed by Expanded Disability Status Scale Revista Científica da Ordem dos Médicos www.actamedicaportuguesa.com Vieira B, et al Prevalence of autonomic dysfunction in patients with multiple sclerosis, Acta Med Port 2015 Jan-Feb;28(1): [51][52][53][54][55] (EDSS) focuses mainly on the somatic nervous system and undervalues the role of autonomic failure, only taking into account bladder and bowel dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Autonomic Dysfunction in Patients with Multiple Sclerosis

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(1):51-55 RESUMOIntrodução: A disfunção do sistema nervoso autónomo é comum na esclerose múltipla e deveria ser explorada na avaliação de rotina. O questionário Composite Autonomic Symptom Score foi validado como instrumento de auto-avaliação de sintomas autonómicos. Objetivos: Determinar a frequência de sintomas autonómicos em doentes com esclerose múltipla através de uma versão portuguesa do Composite Autonomic Symptom Score; comparar os resultados do questionário entre um grupo de doentes e um grupo controlo; avaliar a viabilidade da aplicação deste questionário em doentes portugueses. Material e Métodos: Neste estudo caso-controlo utilizou-se uma tradução portuguesa do questionário para determinar a frequência de sintomas autonómicos em doentes com esclerose múltipla. Resultados: Incluíram-se 103 doentes com esclerose múltipla surto-remissão -idade média 41 anos, mediana de duração da doença 6 anos, EDSS médio 1 -e 80 indivíduos saudáveis. Dos doentes, 97,1% tinham alterações da função autonómica, com significado estatístico nos domínios intolerância ortostática e gastrointestinal. Não encontramos diferenças estatísticas entre doentes (41,7%) sem fatores de confundimento que podiam interferir com a função autonómica (i.e. comorbilidades ou medicações) e o grupo controlo. Discussão: Os resultados obtidos podem estar relacionados com a curta duração de doença, idade jovem e baixo grau de incapacidade dos doentes sem fatores de confundimento. O questionário utilizado não foi desenhado especificamente para a esclerose múltipla e pode não ser tão sensível para sintomas autonómicos mais precoces como para manifestações mais graves da doença. Conclusões: Outros estudos serão necessários para obter resultados mais robustos, validar este questionário e avaliar a sua aplicação nos doentes portugueses. Palavras-chave: Esclerose Múltipla; Portugal; Questionários; Sistema Nervoso Autónomo. ABSTRACT Background:Autonomic nervous system dysfunction is commonly seen in multiple sclerosis patients and should be explored in the routine evaluation. Composite Autonomic Symptom Score questionnaire was validated as a self-assessment instrument of autonomic symptoms. Objectives: Determine the frequency of autonomic symptoms in multiple sclerosis patients through a Portuguese version of Composite Autonomic Symptom Score; compare questionnaire results between patients and a control group; assess the feasibility of this questionnaire application in multiple sclerosis Portuguese patients. Material and Methods:This case-control study used a Portuguese translated version of Composite Autonomic Symptom Score to determine the frequency of autonomic symptoms in multiple sclerosis patients. Results: One-hundred and three relapsing-remitting multiple sclerosis patients -median age 41 years, median disease duration 6 years, median EDSS score 1 -and 80 healthy subjects were included. Alterations in autonomic function were reported in 97.1% of the cases, with statistical significance in orthostatic intolerance and gastrointestinal domain scores....

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Assessment of prevalence and pathological response to orthostatic provocation in patients with multiple sclerosis

Cited by 25 publications

References 21 publications

Autonomic dysfunction in multiple sclerosis presenting with postural orthostatic tachycardia

Autonomic dysfunction in multiple sclerosis presenting with postural orthostatic tachycardia

Autonomic dysfunction in multiple sclerosis

Prevalence of Autonomic Dysfunction in Patients with Multiple Sclerosis

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