Assessment of preoperative liver function in patients with hepatocellular carcinoma: The albumin-indocyanine green evaluation (ALICE) grade.

Kobayashi, Takashi; Hasegawa, Kiyoshi; Amikura, Katsumi; Uldry, Émilie; Shirata, Chikara; Yamaguchi, Takeshi; Arita, Junichi; Kaneko, Junichi; Akamatsu, Nobuhisa; Sakamoto, Yoshihiro; Takahashi, Akiko; Sakamoto, Hirohiko; Makuuchi, Masatoshi; Matsuyama, Yutaka; Demartines, Nicolas; Malagó, Massimo; Halkic, Nermin

doi:10.1200/jco.2016.34.15_suppl.4066

Cited by 8 publications

(16 citation statements)

References 19 publications

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“…21,22 Since the complexity of surgery and the severity of liver cirrhosis are well-known risk factors for mortality and morbidity in hepatectomy for HCC, various studies have been conducted to establish a new evaluation method of surgical indications. 5,9,23,24 Makuuchi’s criteria, 9 widely used in Japan, focused on the value of ICG-R15 as an effective predictor of the safety limit of the extent hepatectomy among patients with HCC. 25 With recent development of a high-quality three-dimensional volumetry 26 and portal vein embolization, 27 the conventional criteria have been expanded to safely achieve an appropriate extent of resection for cure.…”

Section: Discussionmentioning

confidence: 99%

Preoperative nutritional score predicts underlying liver status and surgical risk of hepatocellular carcinoma

et al. 2021

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Background: Given the scarce evidence regarding the impact of preoperative nutritional status on surgical outcomes of patients with hepatocellular carcinoma, predictive powers of nutritional/inflammatory scores for short-term surgical outcomes in patients with hepatocellular carcinoma were investigated. Methods: Outcomes of 1272 patients with hepatocellular carcinoma were reviewed, and predictive powers of nine nutritional/inflammatory scores for short-term surgical outcomes were compared using the receiver-operating characteristic curve analysis. Clinical relevance of the best nutritional score was then studied in detail to clarify its utility as an alternative predictive measure for surgical risk of patients with hepatocellular carcinoma. Results: Receiver-operating characteristic curve analysis showed the controlling nutritional status score has the best performance in prediction of morbidity after hepatectomy for hepatocellular carcinoma (area under the curve, 0.593; 95% confidence interval: 0.552–0.635; p < 0.001), and multivariate analysis confirmed its correlation with the risk of any morbidity (odds ratio per +1 point, 1.17; 95% confidence interval: 1.08–1.27; p < 0.001) and major morbidity (odds ratio per +1 point, 1.14; 95% confidence interval: 0.99–1.27; p = 0.052). The undernutrition grade based on the controlling nutritional status score showed strong correlation with the degree of fibrosis in the liver ( p < 0.001), platelet count ( p < 0.001), and indocyanine green retention rate at 15 min ( p < 0.001). In addition, the controlling nutritional status undernutrition grade well stratified the risk of postoperative morbidity especially in cirrhotic subpopulation (odds ratio, 1.17 per +1 point; 95% confidence interval: 1.05–1.29 for any morbidity and odds ratio, 1.20 per +1 point; 95% confidence interval: 1.03–1.40 for major morbidity). Conclusion: The controlling nutritional status score could be an alternative measure for underlying liver injury and the surgical risk of hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 99%

Preoperative nutritional score predicts underlying liver status and surgical risk of hepatocellular carcinoma

et al. 2021

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“…Indeed, in our previous report, although the number of patients was small, we also showed the utility of the ALICE score for long‐term prognosis in non‐Asian patients. Recently, Russolillo et al . described the usefulness of the ALICE score in Italian HCC patients .…”

Section: Discussionmentioning

confidence: 99%

“…The albumin–bilirubin (ALBI) score was calculated using the following formula: 0.66 × log 10 (total bilirubin [μmol/L]) – 0.085 × (albumin [g/L]), and was graded as grade 1 (−2.60 or less), grade 2 (> −2.60 to −1.39), or grade 3 (> −1.39). The ALICE score was calculated as follows: 0.663 × log 10 (ICG R15 [%]) − 0.0718 × (albumin [g/dL]). The ALICE grade was determined according to the ALICE score as follows: grade 1, −2.20 or less; grade 2a, −2.20 to −1.88 or less; grade 2b, −1.88 to −1.39 or less, and grade 3, greater than −1.39.…”

Section: Methodsmentioning

confidence: 99%

“…The ALICE score was calculated as follows: 0.663 × log 10 (ICG R15 [%]) − 0.0718 × (albumin [g/dL]). The ALICE grade was determined according to the ALICE score as follows: grade 1, −2.20 or less; grade 2a, −2.20 to −1.88 or less; grade 2b, −1.88 to −1.39 or less, and grade 3, greater than −1.39.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we proposed a new model based on long‐term patient survival, called the Albumin–Indocyanine Green Evaluation (ALICE) grading system, as an evaluation tool for preoperative liver functional reserve of patients undergoing hepatectomy for HCC; this score was calculated using the preoperative value of serum albumin level and indocyanine green retention rate at 15 min (ICG R15) . However, the impact of ALICE grade and the comparison of its usefulness with other factors in the prediction of LA and PHLF were not thoroughly investigated in the previous report.…”

Section: Introductionmentioning

confidence: 99%

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Albumin–Indocyanine Green Evaluation (ALICE) grade combined with portal hypertension to predict post‐hepatectomy liver failure

Shirata

Kobayashi

Arita

et al. 2019

Hepatology Research

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Aim The aim of this study was to evaluate the role of liver function factors in predicting a postoperative large‐volume ascites (LA) and post‐hepatectomy liver failure (PHLF). Methods We included 1025 consecutive patients undergoing hepatectomy for hepatocellular carcinoma between 2002 and 2014. Univariate and multivariate analyses were carried out to evaluate the role of each factor of liver function in predicting LA and PHLF. Factors included the presence of portal hypertension (PH), extent of resection, Model for End‐stage Liver Disease (MELD) score, and Albumin–Indocyanine Green Evaluation (ALICE) grade. Results The ALICE score was the strongest predictor for LA (odds ratio [OR], 5.02) and PHLF (OR, 10.94). Conversely, MELD score was not a significant predictive factor for LA or PHLF based on the multivariate analysis. In the ALICE grade 2 group, patients with PH showed a significantly high incidence of developing LA and experiencing PHLF compared with those without PH (LA, 22.4% vs. 10.3%, P < 0.001; PHLF, 8.6% vs. 1.3%, P < 0.001, respectively). Of patients in the ALICE 2 group, those undergoing sectoriectomy or more extensive resection were associated with extremely poor outcomes (LA, 54.2%; PHLF, 29.2%). Conclusions A combination of ALICE grade and presence of PH is a useful predictor of LA and PHLF.

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Update on perioperative management of patients undergoing surgery for liver cancer

Kaibori

Matsui

Shimada

et al. 2021

Annals of Gastroent Surgery

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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. 1 Although most affected patients are in Asia and Africa, HCC incidence and mortality rates are increasing in North America and Europe. 2,3 In Japan, most HCCs occur in patients with chronic hepatitis and liver cirrhosis induced by hepatitis B or C virus infection.Because of advances in perioperative management, anesthesia, and operative techniques, hepatectomy for HCC has become more common. 4 However, the postoperative mortality rate remains higher than in patients with cirrhosis or chronic hepatitis undergoing other types of surgery. The morbidity rate of patients with cirrhosis undergoing liver

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Assessment of preoperative liver function in patients with hepatocellular carcinoma: The albumin-indocyanine green evaluation (ALICE) grade.

Abstract: Background

Cited by 8 publications

References 19 publications

Preoperative nutritional score predicts underlying liver status and surgical risk of hepatocellular carcinoma

Preoperative nutritional score predicts underlying liver status and surgical risk of hepatocellular carcinoma

Albumin–Indocyanine Green Evaluation (ALICE) grade combined with portal hypertension to predict post‐hepatectomy liver failure

Update on perioperative management of patients undergoing surgery for liver cancer

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