Assessment of precipitating factors of breakthrough seizures in epileptic patients

Al-Kattan, Manal; Afifi, Lamia; Shamloul, Reham; Mostafa, Emad El Din

doi:10.4103/1110-1083.162002

Cited by 12 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relative dominance of generalized epilepsies as seizure type is evident in several Egyptian [21], Arabian [22], and developing countries' studies [23]. However, some epidemiological Egyptian [24] [25] and developed countries' studies [26] reported the predominance of focal seizures.…”

Section: Seizure Types and Epilepsy Classificationmentioning

confidence: 99%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

Self Cite

View full text Add to dashboard Cite

Background: Epilepsy is one of the most common neurological conditions. We aimed to identify sex differences in the demographic, clinical features, and treatment strategies in epileptic patients. Objectives: To analyze and compare the differences in the impact of epilepsy on the socio-demographic characteristics of male and female patients along with gender differences in various types of epilepsies and treatment strategies. Material and methods: A record-based study for 1000 individuals attending the epilepsy outpatient clinic. The medical records were reviewed through a predesigned questionnaire to obtain all relevant data. Statistical analysis: Data was summarized using range, mean, standard deviation, and median interquartile range for quantitative variable or frequency and percentage for the qualitative ones. Comparison between groups was done using chi-square test. Results: Females were more illiterate and unemployed compared to males. Tonic-clonic seizures were more frequent in males. Specific epileptic syndromes as juvenile myoclonic epilepsy (JME) were more frequent in females (p = 0.01). More males had an underlying secondary etiology (p = 0.001). The most common drug used was valproate (51.2%) which was more utilized by males. Conclusions: Significant differences between both sexes were observed in certain social impacts in addition to seizure syndromes, etiology, and drug utilization.

show abstract

Section: Seizure Types and Epilepsy Classificationmentioning

confidence: 99%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is supported by different studies. 13 , 24 , 25 The possible reason could be Polytherapy increases the potential for drug–drug interactions, may affect compliance and is associated with a higher cost of medication requirement of therapeutic drug monitoring. 26 In addition, those patients who were resistant to Monotherapy featured by high-frequency seizure attacks are eligible for Polytherapy.…”

Section: Discussionmentioning

confidence: 99%

Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)

Raru¹,

Geremew²,

Tamirat³

2021

NDT

View full text Add to dashboard Cite

Background While getting anti-epileptic drugs (AEDs) treatment around two-thirds of the patients with epilepsy enter a seizure-free state, but some of them continue to experience seizures which increase the risk of accident, disability, death, and treatment side effects. Therefore, this study aimed to identifychanges in the frequency of seizure attacks overtime and associated factors among adult patients with epilepsy. Methods A retrospective two year follow-up study was conducted among adult patients with epilepsy who initiated AEDs between July 2017 and June 2019. A simple random sampling technique was applied to select 394 patient charts. The data were entered into Epi-data and then exported to R software for further analysis. A generalized linear mixed model under a negative binomial family was applied to identify determinants of the frequency of seizure attacks. Results The median number of seizure attacks at baseline were 3 with the IQR of 2 and on average the frequency of seizure attacks decrease in a linear pattern over time. Age group 25–34 years (AIRR = 0.81 and 95% CI: 0.69–0.94), smoking (AIRR = 1.28 and 95% CI: 1.11–1.48), khat use (AIRR = 1.39 and 95% CI: 1.19–1.62), sleep deprivation (AIRR = 1.49 and 95% CI: 1.32–1.69), head injury (AIRR = 1.30 and 95% CI: 1.11–1.53), depression (AIRR = 1.39 and 95% CI: 1.17–1.65), treatment mode (AIRR= 1.22 and 95% CI: 1.07–1.39), and clumsiness (AIRR= 1.85 and 95% CI: 1.24–2.75) were statistically significant seizure predicting factors. Conclusion The number of seizure attack changes over time was decreased by a linear function that might reflect treatment effects of AEDs. Smokers, khat chewers, suffering a head injury, depression, experienced sleep deprivation, and clumsiness increases the number of seizure attacks. Conversely, the age group 25–34 years saw a decrease in the number of seizure attacks. This underscores that special attention should be given to substance users and those with related mental health disorders.

show abstract

“…Retrospective analysis for risk of seizures from infection is challenging as it depends on multisystem and other unrecognized factors implicated during or after the course of illness [6]. There are limited data highlighting breakthrough seizures in clinical practice in the paediatric field especially post-encephalitic complication [7,8].…”

Section: Discussionmentioning

confidence: 99%

Generalized Epilepsy with Right Hemiparesis Secondary to Herpes Encephalitis

Lwin

Naing

Soe

et al. 2020

IJMPCR

View full text Add to dashboard Cite

Herpes simplex encephalitis (HSE) is a medical emergency associated with high mortality and morbidity. Definitive diagnosis is established by history, clinical examination, neuroimaging studies, supportive electroencephalogram (EEG) findings, and cerebrospinal fluid (CSF) analysis. A 7-year-old Malay girl with known case of right hemiplegia secondary to herpes encephalitis presented to the neuropediatric ward, in General Hospital with refractory seizure. She had a moderate learning disability and diagnosed as right hemiparesis secondary to herpes encephalitis complicated with epilepsy. She was planned for the positron emission tomography (PET) scan and to undergo operation if PET scan was feasible (Hemispherectomy). However, the patient refused for operation. Prompt clinical recognition is important in the HSE to prevent progressive brain tissue damage, haemorrhagic changes, and worsening of the encephalitis. Diagnosis is usually confirmed through an extensive evaluation, including a thorough clinical examination with attention to findings on mental status changes, cerebrospinal fluid (CSF) analysis, electroencephalogram (EEG) testing and findings on neuroimaging. Once HSE is suspected, high-dose acyclovir should be started immediately before lumbar puncture (LP), and only stopped once a definitive alternate diagnosis has been established. This case is reported because the patient has generalized epilepsy with right hemiparesis secondary to herpes encephalitis. Herpes encephalitis with right hemiparesis cases are quite rare.

show abstract

Assessment of precipitating factors of breakthrough seizures in epileptic patients

Cited by 12 publications

References 0 publications

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)

Generalized Epilepsy with Right Hemiparesis Secondary to Herpes Encephalitis

Contact Info

Product

Resources

About