Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand

Ruchirawat, Mathuros; Settachan, Daam; Navasumrit, Panida; Tuntawiroon, Jantamas; Autrup, Herman

doi:10.1016/j.toxlet.2006.09.013

Cited by 94 publications

(60 citation statements)

References 47 publications

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“…The levels registered in ambient air of the selected preschool were much higher compared to other Portuguese and Italian cities (Alves et al, 2014;Cirillo et al, 2006). On the contrary, in close proximity of schools situated in Asian countries authors reported much higher concentrations of particle-bound PAHs (Jyethi et al, 2014;Ruchirawat et al, 2006Ruchirawat et al, , 2007 compared to this study. In general, the observed concentrations of outdoor particulate PAHs were higher than the indoor ones, but the compositional profiles were similar.…”

Section: Outdoor Pahs and Source Identificationcontrasting

confidence: 88%

Polycyclic aromatic hydrocarbons: levels and phase distributions in preschool microenvironment

et al. 2014

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This work aims to characterize levels and phase distribution of polycyclic aromatic hydrocarbons (PAHs) in indoor air of preschool environment and to assess the impact of outdoor PAH emissions to indoor environment. Gaseous and particulate (PM 1 and PM 2.5 ) PAHs (16 USEPA priority pollutants, plus dibenzo [a,l] This study fills a gap providing information on levels and phase distribution (gas, and PM 1 and PM 2.5 -bound) of polycyclic aromatic hydrocarbon (PAHs) in preschool educational settings. Despite the current concerns about regulations of indoor pollutants, there is lack of studies on indoor and outdoor PAHs in education settings; in addition, no study reported information about PAHs in the finest fractions of particulates (such as PM 1 ) in schools or preschools. The high proportion of PAHs detected in the gas phase clearly demonstrates that adequate assessment of PAHs exposure requires consideration of the gaseous compounds, which are commonly neglected.

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Section: Outdoor Pahs and Source Identificationcontrasting

confidence: 88%

Polycyclic aromatic hydrocarbons: levels and phase distributions in preschool microenvironment

et al. 2014

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“…2) are higher than levels detected in children in other studies (Mucha et al 2006;Freire et al 2009;Lee et al 2007;NHANES III 2005;Schulz et al 2009;Tuntawiroon et al 2007;Ruchirawat et al 2007). For example, the geometric mean in children aged 6-11 in NHANES III in the United States is »0.05 mol/mol creatinine (0.091 g/L; NHANES III).…”

Section: Discussionmentioning

confidence: 72%

“…For example, the mean level of 1-OHP reported by Ruchirawat et al (2007) in Thai children was 0.18 § 0.01 mol/mol creatinine, while for Domingo, the mean level was 0.2 § 0.2 mol/ mol creatinine. In its turn, children living in El Centro, an urban area with moderate vehicular traYc had similar levels of 1-OHP (0.08 § 0.2 mol/mol creatinine) to children living in other urban areas studied around the world (Freire et al 2009;Hansen et al 2006;Mucha et al 2006;Lee et al 2007).…”

Section: Discussionmentioning

confidence: 93%

Exposure of children to polycyclic aromatic hydrocarbons in Mexico: assessment of multiple sources

Martínez-Salinas

Leal

Batres-Esquivel

et al. 2009

Int Arch Occup Environ Health

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“…Numerous studies have described and evaluated the adverse health effects associated with benzene exposure [Andrews and Snyder, 1991;Smith et al, 1998;IARC, 1999;Duarte-Davidson et al, 2001;Maffei et al, 2005;Ruchirawat et al, 2007;Chanvaivit et al, 2007;Navasumrit et al, 2008;Shen et al, 2008]. Therefore, the major concern regarding benzene centers on the effects of the long-term exposure, both occupationally and environmentally, to decrease the concentrations of this solvent [Qu et al, 2000;Duarte-Davidson et al, 2001].…”

Section: Benzene: Toxicity and Metabolic Pathwaymentioning

confidence: 99%

The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway

Barreto

Madureira

Capani

et al. 2009

Environ and Mol Mutagen

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Benzene is a widespread volatile compound and an environmental contaminant. Since it causes important toxic effects in workers exposed to low levels, long-term exposure to this compound has been extensively studied. Leukemia, blood disorders, bone marrow depression, and some types of cancer are directly related to benzene-initiated toxicity. Bioactivation of benzene can lead to the formation of hazardous metabolites such as phenol, hydroquinone, and catechol. Catechol forms semiquinones and reactive quinones that are presumed to play an important role in the generation of reactive oxygen species (ROS). ROS formation can directly induce single and double strand breaks in the DNA, oxidized nucleotides, and hyper-recombination, and consequently produces deleterious genetic changes. In this review, we have addressed the cytotoxic effects of benzene and its main metabolite, catechol, focusing on the oxidative pathway and further DNA damage.

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Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand

Cited by 94 publications

References 47 publications

Polycyclic aromatic hydrocarbons: levels and phase distributions in preschool microenvironment

Polycyclic aromatic hydrocarbons: levels and phase distributions in preschool microenvironment

Exposure of children to polycyclic aromatic hydrocarbons in Mexico: assessment of multiple sources

The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway

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