Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets

Chen, Jieming; Bhattacharya, Sanchita; Sirota, Marina; Laiudompitak, Sunisa; Schaefer, Henry; Thomson, Elizabeth; Wiser, Jeff; Sarwal, Minnie M.; Butte, Atul J.

doi:10.1001/jamanetworkopen.2019.1851

Cited by 13 publications

(7 citation statements)

References 71 publications

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“…( 68) An additional clinical study on the safety of American living donors reported that 85.3% of donors could not be properly assessed due to the cessation of follow-up or lack of data. (69) This report also showed a high possibility that non-surgical adverse events occurred more than 2 years after donation. (69) Given the results of these studies, both the follow-up rate and period of the present study were su cient to show reliable results.…”

Section: Discussionmentioning

confidence: 70%

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

Tanaka

Yamanaga

Hidaka

et al. 2021

Preprint

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Background: Preoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function.Methods: This was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (<5.5 mg/dl) UA groups. We analyzed the relationship between preoperative UA levels and postoperative estimated glomerular filtration rate (eGFR), as well as adverse events (cardiovascular events and additional prescriptions for hypertension, gout, dyslipidemia, and diabetes mellitus), over 5 years after donation. Results: In total, 44 donors experienced 52 adverse events over 5 years. The incidence of adverse events within 5 years was significantly higher in the high UA group than in the low UA group (50% vs. 24%, p = 0.003); this was true even after the exclusion of hyperuricemia-related events (p = 0.047). UA emerged as an independent risk factor for adverse events (p = 0.012). Donors with higher UA levels had lower eGFRs after donation, whereas body mass index, hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol did not have any impact on the eGFR.Conclusions: The findings suggest that preoperative UA levels should be considered during donor selection and postoperative follow-up.

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Section: Discussionmentioning

confidence: 70%

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

Tanaka

Yamanaga

Hidaka

et al. 2021

Preprint

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“…A significant proportion of LDKT donors (10%) developed low life satisfaction although 96% reported no regrets donating their kidneys at two years [48]. However, long term QOL assessment remains lacking, despite the fact that most non-surgical LDKT complications such as hypertension and diabetes only surface five years post-donation [49]. Therefore, more prospective studies on longer term psychological effects of LDLT and LDKT donors are warranted.…”

Section: Risk Factors For Adverse Mental Outcomes In Donorsmentioning

confidence: 99%

Mental Health and Well-Being of Solid Organ Transplant Donors. The Forgotten Sacrifices

Pan

Toh

et al. 2021

Transplantology

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In light of a global organ shortage, living donor transplantation has become increasingly relevant as an alternative to deceased donor transplantation. While current research has revolved around the medical aspects of transplantation, there remains a paucity of literature regarding the quality of life (QOL) of living donors. Hence, this review aims to provide a comprehensive outline of the current landscape of living liver and kidney transplantation, with a focus on the mental health and wellbeing of donors. As highlighted in previous studies, organ donation has a significant impact on both physical and mental aspects of donor wellbeing, with marked deteriorations occurring in the short term. Furthermore, other qualitative aspects such as financial burden contribute greatly to donor distress, reflecting a need for improved donor care. To address these pertinent issues, recommendations for a successful transplant program are detailed in this review, which encompasses psychological and social aspects of donor care throughout the donation process. Further research can be done on the impact of recipient deaths on donor QOL and appropriate interventions. Overall, given the selfless sacrifices of living donors, the care of their mental wellbeing is essential. Therefore, greater emphasis should be placed on the provision of adequate psychosocial support for them.

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“…A curated data set, immTransplant, with postdonation outcomes for kidney living donors were derived from 20 clinical studies (clinical trials and observational studies) in ImmPort. 41 The availability of such data gives an opportunity to build a "trajectory map" for the sequence of events in a subset of living donors with a long-term follow-up post-donation. This approach retrospectively helps to investigate the patterns of surgical and nonsurgical conditions that may arise post-donation in living donors.…”

Section: Drug Development Toolsmentioning

confidence: 99%

Open Data Revolution in Clinical Research: Opportunities and Challenges

Shahin

Bhattacharya

Silva

et al. 2020

Clinical Translational Sci

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Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated data sets can catalyze biomedical discoveries and drug development. Among the benefits are the fact that data sharing can help generate and investigate new research hypothesis beyond those explored in the original study. Despite several accomplishments establishing public systems and guidance for data sharing in clinical trials, this practice is not the norm. Among the reasons are ethical challenges, such as privacy of individuals, data ownership, and control. This paper creates awareness of the potential benefits and challenges of sharing individual clinical data, how to overcome these challenges, and how as a clinical pharmacology community we can shape future directions in this field.

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Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets

Cited by 13 publications

References 71 publications

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

Mental Health and Well-Being of Solid Organ Transplant Donors. The Forgotten Sacrifices

Open Data Revolution in Clinical Research: Opportunities and Challenges

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