Assessment of polyphenol content and antioxidant activity of oak bark extracts

Dróżdż, Paulina; Pyrzyńska, Krystyna

doi:10.1007/s00107-017-1280-x

Cited by 35 publications

(25 citation statements)

References 7 publications

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“…Over the last years, an increasing number of studies have brought to the fore the diversity of biologically active extracts or metabolites that can be obtained from temperate trees [12,13,[15][16][17]. In a difficult context marked by the widespread increase of microorganism resistance and, therefore, by an urgent need of new antibiotics, it may be assumed that tree barks represent a relevant source of candidates.…”

Section: Discussionmentioning

confidence: 99%

Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts

et al. 2020

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Tree barks are mainly considered as wood wastes from forestry activities, but represent valuable resources as they may contain antimicrobial compounds. Here, we aimed to evaluate the possible antimicrobial activities of bark extracts and to characterize the chemical composition of the most active extract. Ten methanol bark extracts were tested in vitro against 17 bacterial strains and 5 yeast strains, through minimum inhibitory concentration (MIC) and minimum bactericidal (or fungicidal) concentration (MBC/MFC) assays. The extract from Prunus avium (E2-4) displayed the largest bactericidal activity against Gram-positive bacteria, with a lethal effect on 6 out of 8 strains. Antibiofilm assays of E2-4 were performed by crystal violet staining and enumeration of adhered bacteria. Assays demonstrated a biofilm inhibitory effect of E2-4 against Staphylococcus aureus CIP 53.154 at concentrations equal to or higher than 250 µg/mL. Chemical profiling of E2-4 by 13 C nuclear magnetic resonance (NMR) revealed the presence of dihydrowogonin as a major constituent of the extract. E2-4 was fractionated by centrifugal partition chromatography and the three fractions containing dihydrowogonin were tested for their antibacterial and antibiofilm activities, revealing similar activities to those of E2-4. Dihydrowogonin was positively assessed as an interesting antimicrobial compound, which could be valued from wastes of Prunus avium barks.

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Section: Discussionmentioning

confidence: 99%

Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts

et al. 2020

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“…Polyphenols act on tumors by different mechanisms, including the induction of detoxification enzymes and the activation of the antioxidant mechanism, antiproliferation, apoptosis through cell-cycle arrest, and molecular regulation of genes associated with cancer [2,[17][18][19][20]. Tree barks are promising sources of these polyphenols; they contain phenolic acids, flavonoids, and catechins, as well as sugars [2,12,19,21,22]. Phenolic acids are an important group of phenols as they act as antioxidant agents and have, for example, anticancer and antimicrobial properties [3,[23][24][25][26][27].Microbial infections with Staphylococcus aureus cause serious human diseases such as soft tissue infection, pneumonia, sepsis, and peritonitis [28,29].…”

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confidence: 99%

Malus baccata var. gracilis and Malus toringoides Bark Polyphenol Studies and Antioxidant, Antimicrobial and Anticancer Activities

et al. 2020

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Exploring new sources of polyphenols with biological activities that work against human diseases is the target of natural product studies. This study determined the polyphenol composition of the bark of Malus species M. baccata var. gracilis (Rehder) T.C.Ku and M. toringoides (Rehder) Hughes, using high-performance liquid chromatography with a diode-array detector (HPLC-DAD) analysis. The antiproliferative, cytotoxic, antioxidant and antimicrobial applications of these extracts, as well as the identified phenol, were studied. The HPLC-DAD analysis confirmed three polyphenols in the extracts out of the 21 screened compounds: protocatechuic acid, gallic acid, and catechin. The major constituents in M. baccata and M. toringoides were protocatechuic acid, at 3.16 and 7.15 mg 100 g−1 dry weight (DW), respectively, and catechin, at 5.55 and 6.80 mg 100 g−1 DW, respectively. M. baccata and M. toringoides bark extracts showed antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric-reducing antioxidant power (FRAP) assays, which were attributed to the dominance of protocatechuic acid. The highest antiproliferative and cytotoxic effects were against Jurkat cells. Against MCF-7 and Hela cells, there was necrotic cell accumulation in the early apoptotic as well as the late apoptotic phase. The bark extracts showed noticeable antibacterial effects against Listeria monocytogenes, Bacillus cereus, and Escherichia coli. Protocatechuic acid showed comparable results to bark extracts. There were antifungal effects against Aspergillus ochraceus, A. niger, and Candida albicans, and the activities were higher than the commercial reagent. M. baccata and M. toringoides could be considered as a new source of phenolic acids, including protocatechuic acid with anticancer, antibacterial antifungal, and antioxidant-promising effects.

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“…The TFC content of M. elengi Linn was observed to have 23.55 ± 0.80 mg Quercetin Equivalents (QE)/g (Mathur & Vijayvergia, 2017). Another study (Dróżdż & Pyrzynska, 2018) investigated the polyphenol content of oak bark (Quercus robust L.) extracts which has been used to treat skin diseases and found the TFC to range from 35.1 ± 0.2 mg CE/g to 38.0 ± 1.1. Additionally, oak bark is commercially available as a supplement that is rich in tannins, a subdivision of polyphenols, and is used extensively for its anti-inflammatory properties (Dawid-Pać, 2013).…”

Section: Total Flavonoid Content (Tfc) Of Mauby Extractsmentioning

confidence: 99%

An Assessment of Total Polyphenolic Content and Antioxidant Potential of Mauby Bark Extracts (Colubrina arborescens) Brewed for Different Lengths of Time

Embola¹,

Rock²,

Wang³

et al. 2019

JFR

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Mauby bark (Colubrina arborescens) is commonly used to make a beverage,“Mauby”, in the Caribbean and is believed to possess antiglycemic, antilipidemic, and anticarcinogenic properties. However, limited studies have been conducted to substantiate the compounds present that may confer these benefits. Therefore, the objectives of this research were to quantify the total polyphenolic content and evaluate the antioxidant capacity of Mauby bark extracts brewed in water at 30, 45, and 60 minutes. In the extracts, the Total Flavonoid Content (TFC) ranged from 1.93 - 3.17 mg CE/mL and the Total Phenolic Content (TPC) ranged from 2.10 mg ± 0.11 GAE/mL (45 minutes) - 2.36 mg ± 0.067 GAE/mL (30 minutes). Moreover, their antioxidant activity was assessed using the 2,2 Diphenyl 1-Picrylhydrazyl (DPPH) and  Ferric Reducing Antioxidant Power (FRAP) assays. The DPPH scavenging activity observed from Mauby extracts ranged from 75% ± 4.02 (30 minutes) to 83% ± 0.66 (60 minutes) and the FRAP values ranged from 6.29± 0.84 (30 minutes) to 6.90 ± 1.54 mM FeSO4 equivalents/ 0.2 mL Mauby extract (45 minutes). Although, polyphenolic content at 30 minutes was greater than 60 minutes of brewing for TFC (p < 0.001) and TPC (p = 0.002), the scavenging activity was greater at 60 minutes than 30 minutes (p = 0.014) while antioxidant power was not affected by brewing time (p = 0.736). In summary, brewing the bark at 60 minutes was observed to provide the highest antioxidant activity.

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Assessment of polyphenol content and antioxidant activity of oak bark extracts

Cited by 35 publications

References 7 publications

Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts

Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts

Malus baccata var. gracilis and Malus toringoides Bark Polyphenol Studies and Antioxidant, Antimicrobial and Anticancer Activities

An Assessment of Total Polyphenolic Content and Antioxidant Potential of Mauby Bark Extracts (Colubrina arborescens) Brewed for Different Lengths of Time

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